eflornithine has been researched along with Chemical and Drug Induced Liver Injury in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic administration (52 weeks) by gavage to Charles River CD rats at dosages of 400, 800, and 1600 mg/kg produced weight loss, increased platelets, alopecia and skin abrasions, dermatitis, liver necrosis, and gastric inflammation." | 1.29 | Chronic toxicity studies of the potential cancer preventive 2-(difluoromethyl)-dl-ornithine. ( Boone, CW; Crowell, JA; Goldenthal, EI; Kelloff, GJ; Malone, WF, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Putnam, CW | 1 |
| Buckley, AR | 1 |
| Warneke, JA | 1 |
| Karrer, FM | 1 |
| Rhenman, B | 1 |
| Steinbronn, K | 1 |
| Crowell, JA | 1 |
| Goldenthal, EI | 1 |
| Kelloff, GJ | 1 |
| Malone, WF | 1 |
| Boone, CW | 1 |
4 other studies available for eflornithine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
The mechanism of hepatoprotection by epsilon aminocaproic acid and putrescine.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Chemical and Drug Induced Liver Injury; Eflornithine; Ga | 1984 |
Chronic toxicity studies of the potential cancer preventive 2-(difluoromethyl)-dl-ornithine.
Topics: Animals; Anticarcinogenic Agents; Blood Cell Count; Blood Chemical Analysis; Body Weight; Cell Divis | 1994 |