eflornithine has been researched along with Central Nervous System Disease in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DL-alpha-Difluoromethylornithine (DFMO), a specific enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC) was previously shown to cure mice infected with Trypanosoma brucei brucei, a parasite of game and cattle in Africa and Trypanosoma brucei rhodesiense, a human African Sleeping Sickness pathogen." | 3.66 | Further studies on difluoromethylornithine in African trypanosomes. ( Amole, BO; Bacchi, CJ; Clarkson, AB; Hutner, SH; McCann, PP; Nathan, HC; Seed, JR; Sjoerdsma, A, 1981) |
| "DL-alpha-Difluoromethylornithine, a polyamine biosynthesis inhibitor, and bleomycin, a currently used antineoplastic agent, have each previously been shown to be curative for acute short-term infections of mice with Trypanosoma brucei brucei, an African trypanosome closely related to those that cause the human disease African sleeping sickness." | 3.66 | Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. ( Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A, 1983) |
| "Diminazene aceturate was more efficient and provided a 40 mg-kg dose was utilised, it was possible to reduce the period of DFMO to approximately 12 days." | 1.28 | Chemotherapy of CNS-trypanosomiasis: the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethylornithine (DFMO). ( Jennings, FW, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCann, PP | 4 |
| Bacchi, CJ | 4 |
| Clarkson, AB | 3 |
| Seed, JR | 1 |
| Nathan, HC | 3 |
| Amole, BO | 1 |
| Hutner, SH | 1 |
| Sjoerdsma, A | 3 |
| Mellow, GH | 1 |
| Yarlett, N | 1 |
| Goldberg, B | 1 |
| Bitonti, AJ | 2 |
| Jennings, FW | 1 |
5 other studies available for eflornithine and Central Nervous System Disease
| Article | Year |
|---|---|
Further studies on difluoromethylornithine in African trypanosomes.
Topics: Acute Disease; Animals; Arvicolinae; Bleomycin; Carboxy-Lyases; Central Nervous System Diseases; Chr | 1981 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combinati | 1983 |
Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.
Topics: Adenosylmethionine Decarboxylase; Administration, Oral; Animals; Antiprotozoal Agents; Central Nervo | 1992 |
Chemotherapy of CNS-trypanosomiasis: the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethylornithine (DFMO).
Topics: Animals; Arsenicals; Central Nervous System Diseases; Diminazene; Drug Administration Schedule; Drug | 1992 |
Use of difluoromethylornithine (DFMO, eflornithine) for late-stage African trypanosomiasis.
Topics: Animals; Central Nervous System Diseases; Eflornithine; Humans; Mice; Trypanosomiasis, African | 1987 |