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eflornithine and Cell Transformation, Neoplastic

eflornithine has been researched along with Cell Transformation, Neoplastic in 33 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Research Excerpts

ExcerptRelevanceReference
"Recent clinical cancer chemoprevention trials, using dose de-escalation designs, indicate that DFMO can be given over long periods of time at low doses that suppress polyamine contents in gastrointestinal and other epithelial tissues but cause no detectable hearing loss or other side effects."2.40Development of difluoromethylornithine (DFMO) as a chemoprevention agent. ( Gerner, EW; Meyskens, FL, 1999)
"With the incidence of nonmelanoma skin cancer on the rise, current prevention methods, such as the use of sunscreens, have yet to prove adequate to reverse this trend."1.37New agents for prevention of ultraviolet-induced nonmelanoma skin cancer. ( Athar, M; Camp, WL; Elmets, CA; Turnham, JW, 2011)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19908 (24.24)18.7374
1990's12 (36.36)18.2507
2000's8 (24.24)29.6817
2010's5 (15.15)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Akiyama, J1
Alexandre, L1
Baruah, A1
Buttar, N1
Chandra, R1
Clark, AB1
Hart, AR1
Hawk, E1
Kandioler, D1
Kappel, S1
Krishnadath, SK1
Sharma, A1
Singh, I1
Straub, D1
Triadafilopoulos, G1
Umar, A1
Wolf, B1
Evageliou, NF1
Haber, M1
Vu, A1
Laetsch, TW1
Murray, J1
Gamble, LD1
Cheng, NC1
Liu, K1
Reese, M1
Corrigan, KA1
Ziegler, DS1
Webber, H1
Hayes, CS1
Pawel, B1
Marshall, GM1
Zhao, H1
Gilmour, SK2
Norris, MD1
Hogarty, MD1
Alexiou, GA1
Lianos, GD1
Ragos, V1
Galani, V1
Kyritsis, AP1
Camp, WL1
Turnham, JW1
Athar, M1
Elmets, CA1
Bespalov, VG1
Aleksandrov, VA1
Semenov, AL1
Kovan'ko, EG1
Ivanov, SD1
Wax, A1
Yang, C2
Müller, MG1
Nines, R1
Boone, CW2
Steele, VE2
Stoner, GD1
Dasari, RR1
Feld, MS1
Hobbs, CA1
Paul, BA1
Smith, KJ1
Skelton, H1
Shantz, LM1
Levin, VA1
Raul, F1
Gosse, F1
Osswald, AB1
Bouhadjar, M1
Foltzer-Jourdainne, C1
Marescaux, J1
Soler, L1
Medrano, EE1
Goldemberg, SH1
Algranati, ID1
Sugiura, M1
Shafman, T1
Mitchell, T1
Griffin, J1
Kufe, D1
Heby, O2
Oredsson, SM2
Kanje, M1
Sunkara, PS1
Fowler, SK1
Nishioka, K1
Cipolla, B1
Guillé, F1
Moulinoux, JP1
Quemener, V1
Staerman, F1
Corbel, L1
Lobel, B1
Lehnert, T1
Buhl, K1
Ivankovic, S1
Manni, A2
Wechter, R1
Gilmour, S1
Verderame, MF1
Mauger, D1
Demers, LM1
Chen, ZP1
Chen, KY1
Peralta Soler, A1
Gilliard, G1
Megosh, L1
George, K1
O'Brien, TG1
Tabib, A1
Bachrach, U2
Gaylor, D1
Kelloff, GJ1
Meyskens, FL1
Gerner, EW2
Dai, H1
Kramer, DL1
Murti, KG1
Porter, CW2
Cleveland, JL1
Jansen, AP1
Colburn, NH1
Verma, AK1
Krishnan, K1
Ruffin, MT1
Brenner, DE1
Lawson, KR1
Ignatenko, NA1
Piazza, GA1
Cui, H1
Herbert, BS1
Wright, AC1
Passons, CM1
Wright, WE1
Ali, IU1
Kopelovich, L1
Shay, JW1
Auvinen, M1
Paasinen, A1
Andersson, LC1
Hölttä, E1
Glikman, PL1
Bartholomew, M1
Demers, L1
Shtorch, A1
Boyd, D1
Bialoski, S1
Brattain, MG1
Chang, BK1
Libby, PR1
Bergeron, RJ1
Billgren, M1

Reviews

5 reviews available for eflornithine and Cell Transformation, Neoplastic

ArticleYear
Difluoromethylornithine in cancer: new advances.
    Future oncology (London, England), 2017, Volume: 13, Issue:9

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Transformation,

2017
alpha-Difluoromethylornithine, a polyamine inhibitor: its potential role in controlling hair growth and in cancer treatment and chemo-prevention.
    International journal of dermatology, 2006, Volume: 45, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Transformation, Neoplastic; Ef

2006
Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential.
    Amino acids, 2007, Volume: 33, Issue:2

    Topics: Adenosylmethionine Decarboxylase; Animals; Animals, Genetically Modified; Cell Line, Tumor; Cell Tra

2007
Development of difluoromethylornithine (DFMO) as a chemoprevention agent.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cell Division; Cell Trans

1999
Chemoprevention for colorectal cancer.
    Critical reviews in oncology/hematology, 2000, Volume: 33, Issue:3

    Topics: Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Ap

2000

Other Studies

28 other studies available for eflornithine and Cell Transformation, Neoplastic

ArticleYear
Strategy for prevention of cancers of the esophagus.
    Annals of the New York Academy of Sciences, 2014, Volume: 1325

    Topics: Animals; Antineoplastic Agents; Barrett Esophagus; Biomarkers, Tumor; Cell Transformation, Neoplasti

2014
Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Sep-01, Volume: 22, Issue:17

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Cell Line

2016
New agents for prevention of ultraviolet-induced nonmelanoma skin cancer.
    Seminars in cutaneous medicine and surgery, 2011, Volume: 30, Issue:1

    Topics: Anilides; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Carotenoids; Cell Transformation, Neoplas

2011
[Comparative effects of difluoromethylornithine and tincture of Siberian ginseng root on radiation carcinogenesis and life span in rats].
    Advances in gerontology = Uspekhi gerontologii, 2012, Volume: 25, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Eflornithine; Eleutherococcus; Fema

2012
In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry.
    Cancer research, 2003, Jul-01, Volume: 63, Issue:13

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Eflornithine; Epithelial Cells; Esophageal Ne

2003
Elevated levels of polyamines alter chromatin in murine skin and tumors without global changes in nucleosome acetylation.
    Experimental cell research, 2003, Nov-01, Volume: 290, Issue:2

    Topics: Acetylation; Animals; Cell Transformation, Neoplastic; Chromatin; Chromobox Protein Homolog 5; Chrom

2003
Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination.
    International journal of oncology, 2007, Volume: 31, Issue:1

    Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspi

2007
Differential effect of alpha-difluoromethyl-ornithine on the proliferation of Balb 3T3 and chemically transformed 3T3 cells.
    Journal of cellular physiology, 1983, Volume: 117, Issue:2

    Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic;

1983
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
    Blood, 1984, Volume: 63, Issue:5

    Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Hu

1984
Polyamine biosynthetic enzymes as targets in cancer chemotherapy.
    Advances in enzyme regulation, 1984, Volume: 22

    Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Line; Cell Transformatio

1984
Selective killing of transformed cells in combination with inhibitors of polyamine biosynthesis and S-phase specific drugs.
    Cell biology international reports, 1981, Volume: 5, Issue:10

    Topics: Cell Division; Cell Transformation, Neoplastic; Cytarabine; Drug Synergism; Eflornithine; HeLa Cells

1981
Polyamines and prostatic carcinoma: clinical and therapeutic implications.
    European urology, 1993, Volume: 24, Issue:1

    Topics: Adult; Aged; Animals; Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Eflornithin

1993
Inhibition of gastric tumorigenesis by alpha-difluoromethylornithine in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine.
    Journal of cancer research and clinical oncology, 1993, Volume: 119, Issue:10

    Topics: Adenocarcinoma; Adenoma; Animals; Cell Transformation, Neoplastic; Duodenal Neoplasms; Eflornithine;

1993
Ornithine decarboxylase over-expression stimulates mitogen-activated protein kinase and anchorage-independent growth of human breast epithelial cells.
    International journal of cancer, 1997, Jan-17, Volume: 70, Issue:2

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Breast; Calcium-Calmodulin-Dependent Protein K

1997
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.
    Cancer letters, 1997, May-19, Volume: 115, Issue:2

    Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eflornithine; Eukaryotic Translation Initiation

1997
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
    Cancer research, 1998, Apr-15, Volume: 58, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinoma, Papillary; Carcin

1998
Polyamines induce malignant transformation in cultured NIH 3T3 fibroblasts.
    The international journal of biochemistry & cell biology, 1998, Volume: 30, Issue:1

    Topics: 3T3 Cells; Animals; Antineoplastic Agents, Hormonal; Blotting, Western; Cell Division; Cell Transfor

1998
Use of Druckrey analysis to quantitatively evaluate the chemopreventive efficacy of N-difluoromethylornithine (DFMO), a prototype proliferation inhibitor.
    Mutation research, 1998, Jun-18, Volume: 402, Issue:1-2

    Topics: Animals; Anticarcinogenic Agents; Cell Division; Cell Transformation, Neoplastic; Eflornithine; Fema

1998
The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects.
    Cancer research, 1999, Oct-01, Volume: 59, Issue:19

    Topics: Animals; Apoptosis; bcl-X Protein; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Survival; Ce

1999
Tumor promoter-induced ornithine decarboxylase gene expression occurs independently of AP-1 activation.
    Oncogene, 1999, Oct-14, Volume: 18, Issue:42

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Eflornithine; Enzyme Activat

1999
Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2000, Volume: 9, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caco-2 Cells; Cell Survival; Cell Transformation

2000
Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells.
    Journal of the National Cancer Institute, 2001, Jan-03, Volume: 93, Issue:1

    Topics: Antineoplastic Agents; Breast; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cel

2001
Ornithine decarboxylase activity is critical for cell transformation.
    Nature, 1992, Nov-26, Volume: 360, Issue:6402

    Topics: 3T3 Cells; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Division; Cell Transformation, Neopla

1992
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture.
    The Journal of steroid biochemistry and molecular biology, 1990, Volume: 37, Issue:1

    Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Transformation, Neoplastic; Eflornithine; Estradiol;

1990
Formation of cadaverine as an effect of alpha-difluoromethylornithine on chick embryo fibroblasts transformed by rous sarcoma virus.
    Cancer research, 1985, Volume: 45, Issue:5

    Topics: Animals; Avian Sarcoma Viruses; Cadaverine; Cell Transformation, Neoplastic; Cell Transformation, Vi

1985
Effects of difluoromethylornithine and dicyclohexylammonium sulfate on the transformed state of AKR-MCA cells.
    Cancer research, 1987, Aug-01, Volume: 47, Issue:15

    Topics: Animals; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cyclohexylamines; Eflorni

1987
Modulation of polyamine biosynthesis and transport by oncogene transfection.
    Biochemical and biophysical research communications, 1988, Nov-30, Volume: 157, Issue:1

    Topics: Animals; Biological Transport; Cell Division; Cell Line; Cell Transformation, Neoplastic; Eflornithi

1988
Induction of F9 embryonal carcinoma cell differentiation by inhibition of polyamine synthesis.
    European journal of cell biology, 1985, Volume: 38, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromat

1985