eflornithine has been researched along with Cell Transformation, Neoplastic in 33 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent clinical cancer chemoprevention trials, using dose de-escalation designs, indicate that DFMO can be given over long periods of time at low doses that suppress polyamine contents in gastrointestinal and other epithelial tissues but cause no detectable hearing loss or other side effects." | 2.40 | Development of difluoromethylornithine (DFMO) as a chemoprevention agent. ( Gerner, EW; Meyskens, FL, 1999) |
| "With the incidence of nonmelanoma skin cancer on the rise, current prevention methods, such as the use of sunscreens, have yet to prove adequate to reverse this trend." | 1.37 | New agents for prevention of ultraviolet-induced nonmelanoma skin cancer. ( Athar, M; Camp, WL; Elmets, CA; Turnham, JW, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (24.24) | 18.7374 |
| 1990's | 12 (36.36) | 18.2507 |
| 2000's | 8 (24.24) | 29.6817 |
| 2010's | 5 (15.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akiyama, J | 1 |
| Alexandre, L | 1 |
| Baruah, A | 1 |
| Buttar, N | 1 |
| Chandra, R | 1 |
| Clark, AB | 1 |
| Hart, AR | 1 |
| Hawk, E | 1 |
| Kandioler, D | 1 |
| Kappel, S | 1 |
| Krishnadath, SK | 1 |
| Sharma, A | 1 |
| Singh, I | 1 |
| Straub, D | 1 |
| Triadafilopoulos, G | 1 |
| Umar, A | 1 |
| Wolf, B | 1 |
| Evageliou, NF | 1 |
| Haber, M | 1 |
| Vu, A | 1 |
| Laetsch, TW | 1 |
| Murray, J | 1 |
| Gamble, LD | 1 |
| Cheng, NC | 1 |
| Liu, K | 1 |
| Reese, M | 1 |
| Corrigan, KA | 1 |
| Ziegler, DS | 1 |
| Webber, H | 1 |
| Hayes, CS | 1 |
| Pawel, B | 1 |
| Marshall, GM | 1 |
| Zhao, H | 1 |
| Gilmour, SK | 2 |
| Norris, MD | 1 |
| Hogarty, MD | 1 |
| Alexiou, GA | 1 |
| Lianos, GD | 1 |
| Ragos, V | 1 |
| Galani, V | 1 |
| Kyritsis, AP | 1 |
| Camp, WL | 1 |
| Turnham, JW | 1 |
| Athar, M | 1 |
| Elmets, CA | 1 |
| Bespalov, VG | 1 |
| Aleksandrov, VA | 1 |
| Semenov, AL | 1 |
| Kovan'ko, EG | 1 |
| Ivanov, SD | 1 |
| Wax, A | 1 |
| Yang, C | 2 |
| Müller, MG | 1 |
| Nines, R | 1 |
| Boone, CW | 2 |
| Steele, VE | 2 |
| Stoner, GD | 1 |
| Dasari, RR | 1 |
| Feld, MS | 1 |
| Hobbs, CA | 1 |
| Paul, BA | 1 |
| Smith, KJ | 1 |
| Skelton, H | 1 |
| Shantz, LM | 1 |
| Levin, VA | 1 |
| Raul, F | 1 |
| Gosse, F | 1 |
| Osswald, AB | 1 |
| Bouhadjar, M | 1 |
| Foltzer-Jourdainne, C | 1 |
| Marescaux, J | 1 |
| Soler, L | 1 |
| Medrano, EE | 1 |
| Goldemberg, SH | 1 |
| Algranati, ID | 1 |
| Sugiura, M | 1 |
| Shafman, T | 1 |
| Mitchell, T | 1 |
| Griffin, J | 1 |
| Kufe, D | 1 |
| Heby, O | 2 |
| Oredsson, SM | 2 |
| Kanje, M | 1 |
| Sunkara, PS | 1 |
| Fowler, SK | 1 |
| Nishioka, K | 1 |
| Cipolla, B | 1 |
| Guillé, F | 1 |
| Moulinoux, JP | 1 |
| Quemener, V | 1 |
| Staerman, F | 1 |
| Corbel, L | 1 |
| Lobel, B | 1 |
| Lehnert, T | 1 |
| Buhl, K | 1 |
| Ivankovic, S | 1 |
| Manni, A | 2 |
| Wechter, R | 1 |
| Gilmour, S | 1 |
| Verderame, MF | 1 |
| Mauger, D | 1 |
| Demers, LM | 1 |
| Chen, ZP | 1 |
| Chen, KY | 1 |
| Peralta Soler, A | 1 |
| Gilliard, G | 1 |
| Megosh, L | 1 |
| George, K | 1 |
| O'Brien, TG | 1 |
| Tabib, A | 1 |
| Bachrach, U | 2 |
| Gaylor, D | 1 |
| Kelloff, GJ | 1 |
| Meyskens, FL | 1 |
| Gerner, EW | 2 |
| Dai, H | 1 |
| Kramer, DL | 1 |
| Murti, KG | 1 |
| Porter, CW | 2 |
| Cleveland, JL | 1 |
| Jansen, AP | 1 |
| Colburn, NH | 1 |
| Verma, AK | 1 |
| Krishnan, K | 1 |
| Ruffin, MT | 1 |
| Brenner, DE | 1 |
| Lawson, KR | 1 |
| Ignatenko, NA | 1 |
| Piazza, GA | 1 |
| Cui, H | 1 |
| Herbert, BS | 1 |
| Wright, AC | 1 |
| Passons, CM | 1 |
| Wright, WE | 1 |
| Ali, IU | 1 |
| Kopelovich, L | 1 |
| Shay, JW | 1 |
| Auvinen, M | 1 |
| Paasinen, A | 1 |
| Andersson, LC | 1 |
| Hölttä, E | 1 |
| Glikman, PL | 1 |
| Bartholomew, M | 1 |
| Demers, L | 1 |
| Shtorch, A | 1 |
| Boyd, D | 1 |
| Bialoski, S | 1 |
| Brattain, MG | 1 |
| Chang, BK | 1 |
| Libby, PR | 1 |
| Bergeron, RJ | 1 |
| Billgren, M | 1 |
5 reviews available for eflornithine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Difluoromethylornithine in cancer: new advances.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Transformation, | 2017 |
alpha-Difluoromethylornithine, a polyamine inhibitor: its potential role in controlling hair growth and in cancer treatment and chemo-prevention.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Transformation, Neoplastic; Ef | 2006 |
Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential.
Topics: Adenosylmethionine Decarboxylase; Animals; Animals, Genetically Modified; Cell Line, Tumor; Cell Tra | 2007 |
Development of difluoromethylornithine (DFMO) as a chemoprevention agent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cell Division; Cell Trans | 1999 |
Chemoprevention for colorectal cancer.
Topics: Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Ap | 2000 |
28 other studies available for eflornithine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Strategy for prevention of cancers of the esophagus.
Topics: Animals; Antineoplastic Agents; Barrett Esophagus; Biomarkers, Tumor; Cell Transformation, Neoplasti | 2014 |
Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Cell Line | 2016 |
New agents for prevention of ultraviolet-induced nonmelanoma skin cancer.
Topics: Anilides; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Carotenoids; Cell Transformation, Neoplas | 2011 |
[Comparative effects of difluoromethylornithine and tincture of Siberian ginseng root on radiation carcinogenesis and life span in rats].
Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Eflornithine; Eleutherococcus; Fema | 2012 |
In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Eflornithine; Epithelial Cells; Esophageal Ne | 2003 |
Elevated levels of polyamines alter chromatin in murine skin and tumors without global changes in nucleosome acetylation.
Topics: Acetylation; Animals; Cell Transformation, Neoplastic; Chromatin; Chromobox Protein Homolog 5; Chrom | 2003 |
Follow-up of tumor development in the colons of living rats and implications for chemoprevention trials: assessment of aspirin-difluoromethylornithine combination.
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspi | 2007 |
Differential effect of alpha-difluoromethyl-ornithine on the proliferation of Balb 3T3 and chemically transformed 3T3 cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; | 1983 |
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Hu | 1984 |
Polyamine biosynthetic enzymes as targets in cancer chemotherapy.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Line; Cell Transformatio | 1984 |
Selective killing of transformed cells in combination with inhibitors of polyamine biosynthesis and S-phase specific drugs.
Topics: Cell Division; Cell Transformation, Neoplastic; Cytarabine; Drug Synergism; Eflornithine; HeLa Cells | 1981 |
Polyamines and prostatic carcinoma: clinical and therapeutic implications.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Eflornithin | 1993 |
Inhibition of gastric tumorigenesis by alpha-difluoromethylornithine in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Adenocarcinoma; Adenoma; Animals; Cell Transformation, Neoplastic; Duodenal Neoplasms; Eflornithine; | 1993 |
Ornithine decarboxylase over-expression stimulates mitogen-activated protein kinase and anchorage-independent growth of human breast epithelial cells.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Breast; Calcium-Calmodulin-Dependent Protein K | 1997 |
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eflornithine; Eukaryotic Translation Initiation | 1997 |
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinoma, Papillary; Carcin | 1998 |
Polyamines induce malignant transformation in cultured NIH 3T3 fibroblasts.
Topics: 3T3 Cells; Animals; Antineoplastic Agents, Hormonal; Blotting, Western; Cell Division; Cell Transfor | 1998 |
Use of Druckrey analysis to quantitatively evaluate the chemopreventive efficacy of N-difluoromethylornithine (DFMO), a prototype proliferation inhibitor.
Topics: Animals; Anticarcinogenic Agents; Cell Division; Cell Transformation, Neoplastic; Eflornithine; Fema | 1998 |
The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects.
Topics: Animals; Apoptosis; bcl-X Protein; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Survival; Ce | 1999 |
Tumor promoter-induced ornithine decarboxylase gene expression occurs independently of AP-1 activation.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Eflornithine; Enzyme Activat | 1999 |
Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caco-2 Cells; Cell Survival; Cell Transformation | 2000 |
Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells.
Topics: Antineoplastic Agents; Breast; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cel | 2001 |
Ornithine decarboxylase activity is critical for cell transformation.
Topics: 3T3 Cells; Animals; Avian Sarcoma Viruses; Base Sequence; Cell Division; Cell Transformation, Neopla | 1992 |
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Transformation, Neoplastic; Eflornithine; Estradiol; | 1990 |
Formation of cadaverine as an effect of alpha-difluoromethylornithine on chick embryo fibroblasts transformed by rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Cadaverine; Cell Transformation, Neoplastic; Cell Transformation, Vi | 1985 |
Effects of difluoromethylornithine and dicyclohexylammonium sulfate on the transformed state of AKR-MCA cells.
Topics: Animals; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Cyclohexylamines; Eflorni | 1987 |
Modulation of polyamine biosynthesis and transport by oncogene transfection.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cell Transformation, Neoplastic; Eflornithi | 1988 |
Induction of F9 embryonal carcinoma cell differentiation by inhibition of polyamine synthesis.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromat | 1985 |