eflornithine has been researched along with Cardiomegaly in 6 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Whether DFMO attenuates cardiac hypertrophy through endoplasmic reticulum stress (ERS) is unclear." | 5.43 | Endoplasmic Reticulum Stress is Involved in DFMO Attenuating Isoproterenol-Induced Cardiac Hypertrophy in Rats. ( Jin, L; Li, B; Lian, J; Lin, Y; Liu, J; Wang, J; Xiao, W; Zhang, X; Zhou, L, 2016) |
| "The responses of AMP-activated protein kinase (AMPK) and Ornithine decarboxylase (ODC) to isoproterenol have been examined in H9c2 cardiomyoblasts, AMPK represents the link between cell growth and energy availability whereas ODC, the key enzyme in polyamine biosynthesis, is essential for all growth processes and it is thought to have a role in the development of cardiac hypertrophy." | 3.78 | Evidence that AMP-activated protein kinase can negatively modulate ornithine decarboxylase activity in cardiac myoblasts. ( Caldarera, CM; Campana, G; Cetrullo, S; Flamigni, F; Gottardi, D; Guarnieri, C; Passariello, CL; Pignatti, C; Stefanelli, C; Tantini, B; Zini, M, 2012) |
| "In this study, we determined whether the persistency of cardiac hypertrophy after chronic vasodilation therapy with minoxidil (minox) was associated with functional or metabolic alterations in hypertensive rat hearts before, during and after an ischemic insult." | 3.68 | [Effect of long-term administration of vasodilators and "antitrophic" agents on the structure and function of the heart in hypertensive rats]. ( Carlier, P; Gilles, R; Rorive, G; Smelten, N, 1990) |
| "Whether DFMO attenuates cardiac hypertrophy through endoplasmic reticulum stress (ERS) is unclear." | 1.43 | Endoplasmic Reticulum Stress is Involved in DFMO Attenuating Isoproterenol-Induced Cardiac Hypertrophy in Rats. ( Jin, L; Li, B; Lian, J; Lin, Y; Liu, J; Wang, J; Xiao, W; Zhang, X; Zhou, L, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, Y | 1 |
| Zhang, X | 1 |
| Xiao, W | 1 |
| Li, B | 1 |
| Wang, J | 1 |
| Jin, L | 1 |
| Lian, J | 1 |
| Zhou, L | 1 |
| Liu, J | 1 |
| Passariello, CL | 1 |
| Gottardi, D | 1 |
| Cetrullo, S | 1 |
| Zini, M | 1 |
| Campana, G | 1 |
| Tantini, B | 1 |
| Pignatti, C | 1 |
| Flamigni, F | 1 |
| Guarnieri, C | 1 |
| Caldarera, CM | 1 |
| Stefanelli, C | 1 |
| Bartolome, JV | 1 |
| Trepanier, PA | 1 |
| Chait, EA | 1 |
| Slotkin, TA | 2 |
| Bartolome, J | 1 |
| Huguenard, J | 1 |
| Pegg, AE | 1 |
| Carlier, P | 1 |
| Smelten, N | 1 |
| Gilles, R | 1 |
| Rorive, G | 1 |
6 other studies available for eflornithine and Cardiomegaly
| Article | Year |
|---|---|
Endoplasmic Reticulum Stress is Involved in DFMO Attenuating Isoproterenol-Induced Cardiac Hypertrophy in Rats.
Topics: Acetyltransferases; Animals; Antineoplastic Agents; Apoptosis; Atrial Natriuretic Factor; bcl-2-Asso | 2016 |
Evidence that AMP-activated protein kinase can negatively modulate ornithine decarboxylase activity in cardiac myoblasts.
Topics: AMP-Activated Protein Kinases; Animals; Cardiomegaly; Down-Regulation; Eflornithine; Gene Expression | 2012 |
Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Cardiomegaly; Eflornithine; Isoproterenol; Male; Ornithine; Ornithine Decarboxylase Inhibit | 1982 |
Role of ornithine decarboxylase in cardiac growth and hypertrophy.
Topics: Animals; Carboxy-Lyases; Cardiomegaly; Eflornithine; Heart; Isoproterenol; Male; Myocardium; Ornithi | 1980 |
Effect of alpha-difluoromethylornithine on cardiac polyamine content and hypertrophy.
Topics: Animals; Cardiomegaly; Eflornithine; Heart; Male; Myocardium; Ornithine; Ornithine Decarboxylase Inh | 1981 |
[Effect of long-term administration of vasodilators and "antitrophic" agents on the structure and function of the heart in hypertensive rats].
Topics: Animals; Cardiomegaly; Drug Therapy, Combination; Eflornithine; Heart Ventricles; Hemodynamics; Hype | 1990 |