eflornithine has been researched along with Carcinoma, Small Cell in 8 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Small cell lung carcinoma cells die following polyamine depletion by difluoromethylornithine treatment while non-small cell lines demonstrate a typical cytostatic response." | 3.67 | Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels. ( Baylin, SB; Casero, RA; Luk, GD; Nelkin, BD, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luk, GD | 5 |
| Goodwin, G | 1 |
| Marton, LJ | 1 |
| Baylin, SB | 7 |
| Twentyman, PR | 1 |
| Wright, KA | 1 |
| Wallace, HM | 1 |
| Falco, JP | 1 |
| Lupu, R | 1 |
| Borges, M | 1 |
| Nelkin, BD | 3 |
| Jasti, RK | 1 |
| Davidson, NE | 1 |
| Mabry, M | 2 |
| Nakagawa, T | 1 |
| McDowell, E | 1 |
| Gesell, M | 1 |
| Eggleston, JC | 1 |
| Casero, RA | 2 |
| Abeloff, MD | 2 |
| McCann, PP | 1 |
| Sjoerdsma, A | 2 |
| Rosen, ST | 1 |
| Zeltzman, M | 1 |
8 other studies available for eflornithine and Carcinoma, Small Cell
| Article | Year |
|---|---|
Polyamines are necessary for the survival of human small-cell lung carcinoma in culture.
Topics: Carcinoma, Small Cell; Cell Aggregation; Cell Division; Cell Survival; Cells, Cultured; Eflornithine | 1981 |
Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; Cel | 1992 |
v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line.
Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Eflornithine; Epidermal Growth | 1990 |
v-Ha-ras oncogene insertion: a model for tumor progression of human small cell lung cancer.
Topics: Carcinoembryonic Antigen; Carcinoma, Small Cell; Cell Division; Cell Line; Clone Cells; DNA Transpos | 1988 |
Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
Topics: Carcinoma; Carcinoma, Small Cell; Cell Cycle; Cells, Cultured; Eflornithine; Humans; Lung Neoplasms; | 1986 |
Anchorage dependency effects on difluoromethylornithine cytotoxicity in human lung carcinoma cells.
Topics: Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Aggregation; Cell Communication; Cell Survival | 1986 |
Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine.
Topics: Animals; Body Weight; Carcinoma, Small Cell; Cell Aggregation; Eflornithine; Female; Lung Neoplasms; | 1986 |
Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer.
Topics: Aged; Antineoplastic Agents; Carcinoma, Small Cell; Colonic Neoplasms; Drug Evaluation; Eflornithine | 1986 |