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eflornithine and Carcinoma, Small Cell

eflornithine has been researched along with Carcinoma, Small Cell in 8 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

Research Excerpts

ExcerptRelevanceReference
" Small cell lung carcinoma cells die following polyamine depletion by difluoromethylornithine treatment while non-small cell lines demonstrate a typical cytostatic response."3.67Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels. ( Baylin, SB; Casero, RA; Luk, GD; Nelkin, BD, 1986)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19906 (75.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Luk, GD5
Goodwin, G1
Marton, LJ1
Baylin, SB7
Twentyman, PR1
Wright, KA1
Wallace, HM1
Falco, JP1
Lupu, R1
Borges, M1
Nelkin, BD3
Jasti, RK1
Davidson, NE1
Mabry, M2
Nakagawa, T1
McDowell, E1
Gesell, M1
Eggleston, JC1
Casero, RA2
Abeloff, MD2
McCann, PP1
Sjoerdsma, A2
Rosen, ST1
Zeltzman, M1

Other Studies

8 other studies available for eflornithine and Carcinoma, Small Cell

ArticleYear
Polyamines are necessary for the survival of human small-cell lung carcinoma in culture.
    Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:4

    Topics: Carcinoma, Small Cell; Cell Aggregation; Cell Division; Cell Survival; Cells, Cultured; Eflornithine

1981
Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro.
    British journal of cancer, 1992, Volume: 65, Issue:3

    Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; Cel

1992
v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line.
    The Journal of clinical investigation, 1990, Volume: 85, Issue:6

    Topics: Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Eflornithine; Epidermal Growth

1990
v-Ha-ras oncogene insertion: a model for tumor progression of human small cell lung cancer.
    Proceedings of the National Academy of Sciences of the United States of America, 1988, Volume: 85, Issue:17

    Topics: Carcinoembryonic Antigen; Carcinoma, Small Cell; Cell Division; Cell Line; Clone Cells; DNA Transpos

1988
Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
    Biochemical and biophysical research communications, 1986, Jan-29, Volume: 134, Issue:2

    Topics: Carcinoma; Carcinoma, Small Cell; Cell Cycle; Cells, Cultured; Eflornithine; Humans; Lung Neoplasms;

1986
Anchorage dependency effects on difluoromethylornithine cytotoxicity in human lung carcinoma cells.
    Cancer research, 1986, Volume: 46, Issue:4 Pt 1

    Topics: Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Aggregation; Cell Communication; Cell Survival

1986
Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine.
    Cancer research, 1986, Volume: 46, Issue:4 Pt 1

    Topics: Animals; Body Weight; Carcinoma, Small Cell; Cell Aggregation; Eflornithine; Female; Lung Neoplasms;

1986
Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer.
    Cancer treatment reports, 1986, Volume: 70, Issue:7

    Topics: Aged; Antineoplastic Agents; Carcinoma, Small Cell; Colonic Neoplasms; Drug Evaluation; Eflornithine

1986