eflornithine has been researched along with Carcinoma, Hepatocellular in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 7.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 3.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| " The antimalarial drug, primaquine, the side chain of which is structurally analogous to a natural polyamine, did not enhance the activity of alpha-difluoromethylornithine or alpha-monofluoromethyldehydroornithine methyl ester." | 3.67 | Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony. ( Hollingdale, MR; McCann, PP; Sjoerdsma, A, 1985) |
| "Macrophage-like RAW 264 and H35 hepatoma cells grown under serum-free conditions exported putrescine and an unidentified diamine into the culture medium." | 1.29 | Biosynthesis and selective export of 1,5-diaminopentane (cadaverine) in mycoplasma-free cultured mammalian cells. ( Byus, CV; Fukumoto, GH; Hawel, L; Tjandrawinata, RR, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Santos, AA | 1 |
| Stubbs, AP | 1 |
| Maghsoudloo, M | 1 |
| Murphy, GM | 1 |
| Wilkinson, ML | 1 |
| Hawel, L | 1 |
| Tjandrawinata, RR | 1 |
| Fukumoto, GH | 1 |
| Byus, CV | 1 |
| Ashida, Y | 1 |
| Ueno, A | 1 |
| Miwa, Y | 1 |
| Miyoshi, K | 1 |
| Inoue, H | 1 |
| Nakagawa, T | 1 |
| Nakao, Y | 1 |
| Matsui, T | 1 |
| Koizumi, T | 1 |
| Watanabe, S | 1 |
| Fujita, T | 1 |
| Hollingdale, MR | 1 |
| McCann, PP | 1 |
| Sjoerdsma, A | 1 |
5 other studies available for eflornithine and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Polyamine metabolism in human hepatocellular cancer cells (Hep-G2).
Topics: Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Eflornithine; Humans; Liv | 1994 |
Biosynthesis and selective export of 1,5-diaminopentane (cadaverine) in mycoplasma-free cultured mammalian cells.
Topics: Amino Acids; Animals; Biological Transport; Cadaverine; Carcinoma, Hepatocellular; Cell Line; Cultur | 1994 |
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell | 1998 |
Effects of alpha-difluoromethyl ornithine on alpha-fetoprotein and albumin secretion in human hepatoma cell line, PLC/PRF/5.
Topics: Albumins; alpha-Fetoproteins; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dose-Response Rel | 1985 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; | 1985 |