eflornithine has been researched along with Carcinoma, Epidermoid in 23 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Our intention was to retrospectively assess the further incidence of skin cancer, other malignancies, and adverse events of patients accrued to our phase III skin cancer prevention study of DFMO." | 2.77 | A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity. ( Bailey, HH; Borich, A; Havighurst, T; Kim, K; Kreul, SM; Mendonça, EA; Snow, S; Verma, A; Wood, GS, 2012) |
| "Subjects with a history of skin cancer taking daily DFMO had an insignificant reduction (P = 0." | 2.75 | A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer. ( Bailey, HH; Berg, ER; Carbone, PP; Douglas, J; Dreckschmidt, NE; Hamielec, M; Havighurst, TC; Kim, K; Larson, PO; Lenaghan, T; Pomplun, M; Puchalsky, D; Sharata, HH; Sielaff, K; Snow, S; Verma, AK; Viner, JL, 2010) |
| "Non-melanoma skin cancer (NMSC) is the most common type of skin cancer in Caucasian populations." | 1.39 | Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis. ( Afaq, F; Arumugam, A; Athar, M; Chaudhary, SC; Elmets, CA; Kopelovich, L; Talwelkar, SS; Weng, Z, 2013) |
| "With the incidence of nonmelanoma skin cancer on the rise, current prevention methods, such as the use of sunscreens, have yet to prove adequate to reverse this trend." | 1.37 | New agents for prevention of ultraviolet-induced nonmelanoma skin cancer. ( Athar, M; Camp, WL; Elmets, CA; Turnham, JW, 2011) |
| " This paper discusses the development of a group of lipophilic polyamine analogues that potently inhibit the cellular polyamine uptake system and greatly increase the effectiveness of polyamine depletion when used in combination with DFMO, a well-studied polyamine biosynthesis inhibitor." | 1.35 | Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor. ( Burns, MR; Chen, Y; Graminski, GF; O'Brien, TG; Weeks, RS, 2009) |
| "However, DFMO treatment led to marked hair loss in PKC epsilon transgenic mice." | 1.32 | Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. ( Ness, KJ; Oberley, TD; Verma, AK; Wheeler, DL, 2003) |
| "Infiltrating squamous cell carcinomas of the URT occurred in 92% of the controls and were reduced by 50% in animals receiving DFMO (P = 0." | 1.32 | Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil. ( Estensen, RD; Wattenberg, LW; Wiedmann, TS, 2004) |
| "Human lung squamous carcinoma cells L78 treated with 5 mmol/L alpha-difluoromethylornithine (DFMO) for 5 days showed significant growth inhibition and apoptosis induction." | 1.31 | [Effect of alpha-difluoromethylornithine on growth characteristics and expression of ALT-04ag gene of human lung carcinoma cells]. ( Cao, SL; Chen, ZH; Fan, MZ; Fang, Q; Ke, HP; Li, HY, 2002) |
| "Three human squamous cell carcinoma (SCC) cell lines, derived from primary head and neck cancers, have been characterized in vitro via flow cytometric analysis of proliferation kinetics, and in vivo via tumor xenograft growth evaluation in athymic mice." | 1.29 | Modulation of proliferation kinetics in human squamous cell carcinomas of the head and neck. ( Contreras, L; Harari, PM; Kinsella, TJ; Pickart, MA; Ritter, MA, 1993) |
| "The probes also located squamous cell carcinoma cells in human skin." | 1.28 | Fluorescent location of ornithine decarboxylase employing derivatives of the specific inhibitor alpha-difluoromethyl ornithine. ( Steven, FS; Tucker, DF; Warne, P; Williams, LA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 8 (34.78) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burns, MR | 2 |
| Graminski, GF | 1 |
| Weeks, RS | 2 |
| Chen, Y | 2 |
| O'Brien, TG | 4 |
| Arumugam, A | 1 |
| Weng, Z | 1 |
| Talwelkar, SS | 1 |
| Chaudhary, SC | 1 |
| Kopelovich, L | 2 |
| Elmets, CA | 2 |
| Afaq, F | 1 |
| Athar, M | 3 |
| Lewis, JR | 2 |
| Skorupski, KA | 1 |
| Krick, EL | 1 |
| Reiter, AM | 1 |
| Jennings, MW | 1 |
| Jurney, CH | 1 |
| Shofer, FS | 1 |
| Bailey, HH | 2 |
| Kim, K | 2 |
| Verma, AK | 3 |
| Sielaff, K | 1 |
| Larson, PO | 1 |
| Snow, S | 2 |
| Lenaghan, T | 1 |
| Viner, JL | 1 |
| Douglas, J | 1 |
| Dreckschmidt, NE | 1 |
| Hamielec, M | 1 |
| Pomplun, M | 1 |
| Sharata, HH | 1 |
| Puchalsky, D | 1 |
| Berg, ER | 1 |
| Havighurst, TC | 1 |
| Carbone, PP | 1 |
| Gendler, A | 1 |
| Reetz, JA | 1 |
| Schwarz, T | 1 |
| Camp, WL | 1 |
| Turnham, JW | 1 |
| Prado, R | 1 |
| Francis, SO | 1 |
| Mason, MN | 1 |
| Wing, G | 1 |
| Gamble, RG | 1 |
| Dellavalle, R | 1 |
| Kreul, SM | 1 |
| Havighurst, T | 1 |
| Mendonça, EA | 1 |
| Wood, GS | 1 |
| Borich, A | 1 |
| Verma, A | 1 |
| Wheeler, DL | 1 |
| Ness, KJ | 1 |
| Oberley, TD | 1 |
| Chen, ZH | 1 |
| Ke, HP | 1 |
| Li, HY | 1 |
| Fang, Q | 1 |
| Cao, SL | 1 |
| Fan, MZ | 1 |
| Wattenberg, LW | 1 |
| Wiedmann, TS | 1 |
| Estensen, RD | 1 |
| Tang, X | 1 |
| Kim, AL | 1 |
| Feith, DJ | 1 |
| Pegg, AE | 1 |
| Russo, J | 1 |
| Zhang, H | 1 |
| Aszterbaum, M | 1 |
| Epstein, EH | 1 |
| Bickers, DR | 1 |
| Boorman, DW | 1 |
| Klein-Szanto, A | 1 |
| Petereit, DG | 1 |
| Harari, PM | 3 |
| Contreras, L | 2 |
| Pickart, MA | 3 |
| Gerner, EW | 1 |
| Kinsella, TJ | 2 |
| Ritter, MA | 1 |
| Peralta Soler, A | 1 |
| Gilliard, G | 1 |
| Megosh, L | 1 |
| George, K | 1 |
| Mitsunaga, S | 1 |
| Clapper, M | 1 |
| Litwin, S | 1 |
| Watts, P | 1 |
| Bauer, B | 1 |
| Klein-Szanto, AJ | 1 |
| Arbeit, JM | 1 |
| Riley, RR | 1 |
| Huey, B | 1 |
| Porter, C | 1 |
| Kelloff, G | 1 |
| Lubet, R | 1 |
| Ward, JM | 1 |
| Pinkel, D | 1 |
| Poulin, N | 1 |
| Boiko, I | 1 |
| MacAulay, C | 1 |
| Boone, C | 1 |
| Nishioka, K | 1 |
| Hittelman, W | 1 |
| Mitchell, MF | 1 |
| Bock, JM | 1 |
| Pink, JJ | 1 |
| Garewal, HS | 1 |
| Steven, FS | 1 |
| Williams, LA | 1 |
| Warne, P | 1 |
| Tucker, DF | 1 |
| Luk, GD | 1 |
| Baylin, SB | 1 |
2 reviews available for eflornithine and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Nonmelanoma skin cancer chemoprevention.
Topics: Acitretin; Aminolevulinic Acid; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Carc | 2011 |
Chemoprevention of Barrett's esophagus and oral leukoplakia.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Barrett Esophagus; Biomarkers; Carcinoma, Squamous Cell; Ca | 1992 |
4 trials available for eflornithine and Carcinoma, Epidermoid
| Article | Year |
|---|---|
A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer.
Topics: Antineoplastic Agents; Audiometry; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Double-Blind Met | 2010 |
A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity.
Topics: Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Double-Blind Method; Eflornithine; Fem | 2012 |
Nuclear morphometry as an intermediate endpoint biomarker in chemoprevention of cervical carcinoma using alpha-difluoromethylornithine.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Nucleus; Disease Progressio | 1999 |
Chemoprevention of Barrett's esophagus and oral leukoplakia.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Barrett Esophagus; Biomarkers; Carcinoma, Squamous Cell; Ca | 1992 |
18 other studies available for eflornithine and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biological Transport | 2009 |
Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis.
Topics: Animals; Carcinoma, Squamous Cell; Carrier Proteins; Cell Line, Tumor; Cell Movement; Cell Prolifera | 2013 |
Polyamine inhibitors for treatment of feline oral squamous cell carcinoma: a proof-of-concept study.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cat Diseases; Cats; Eflornithine; Evoked P | 2013 |
Computed tomographic features of oral squamous cell carcinoma in cats: 18 cases (2002-2008).
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Carcinoma, Squa | 2010 |
New agents for prevention of ultraviolet-induced nonmelanoma skin cancer.
Topics: Anilides; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Carotenoids; Cell Transformation, Neoplas | 2011 |
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Topics: Administration, Oral; Alopecia; Animals; Benz(a)Anthracenes; Carcinogens; Carcinoma, Squamous Cell; | 2003 |
[Effect of alpha-difluoromethylornithine on growth characteristics and expression of ALT-04ag gene of human lung carcinoma cells].
Topics: Antigens, Neoplasm; Apoptosis; Carcinoma, Squamous Cell; Cell Division; Down-Regulation; Eflornithin | 2002 |
Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil.
Topics: Administration, Inhalation; Aerosols; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Squa | 2004 |
Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice.
Topics: Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Eflornithine; Heterozygote; Intracellular | 2004 |
Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Drug Therapy, Combination; Eflo | 2006 |
Combining polyamine depletion with radiation therapy for rapidly dividing head and neck tumors: strategies for improved locoregional control.
Topics: Animals; Carcinoma, Squamous Cell; Cell Survival; Combined Modality Therapy; Eflornithine; Female; F | 1994 |
Modulation of proliferation kinetics in human squamous cell carcinomas of the head and neck.
Topics: Animals; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Eflornithine; Flow Cytometry; Head and | 1993 |
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinoma, Papillary; Carcin | 1998 |
Chemopreventive effect of difluoromethylornithine (DFMO) on mouse skin squamous cell carcinomas induced by benzo(a)pyrene.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Eflornithine; Female; Hyperplasia; M | 1997 |
Difluoromethylornithine chemoprevention of epidermal carcinogenesis in K14-HPV16 transgenic mice.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Disease Progressio | 1999 |
Modulation of tumor cell proliferation and apoptosis by polyamine depletion in cells of head and neck squamous cell carcinomas.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Dose-Response Relationship, Drug; | 1999 |
Fluorescent location of ornithine decarboxylase employing derivatives of the specific inhibitor alpha-difluoromethyl ornithine.
Topics: Animals; Binding, Competitive; Carcinoma, Squamous Cell; Eflornithine; Fluorescent Dyes; Humans; Mic | 1989 |
Anchorage dependency effects on difluoromethylornithine cytotoxicity in human lung carcinoma cells.
Topics: Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Aggregation; Cell Communication; Cell Survival | 1986 |