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eflornithine and Carcinoma, Anaplastic

eflornithine has been researched along with Carcinoma, Anaplastic in 12 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
" Small cell lung carcinoma cells die following polyamine depletion by difluoromethylornithine treatment while non-small cell lines demonstrate a typical cytostatic response."3.67Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels. ( Baylin, SB; Casero, RA; Luk, GD; Nelkin, BD, 1986)
" DFMO has shown a dose-response effect in tumor inhibition in mice."2.67Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine. ( Carbone, PP; Carey, P; Gilmore, D; Love, RR; Pomplun, M; Tutsch, KD; Verma, AK; Wilding, G, 1993)
" ODC gene dosage was analyzed by Southern blot hybridization and was 4- to 12-fold higher in T-47D, MDA-MB-231, and BT-20 cell lines than in the MCF-7 cell line."1.28Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells. ( Jänne, OA; Kiang, DT; Thomas, T; Thomas, TJ, 1991)
"PA involvement in IGFBPs production by breast cancer cells is complex and may involve differential regulation of transcriptional and post-translational events."1.28Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines. ( Hammond, JM; Kim, I; Lynch, J; Manni, A, 1991)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's6 (50.00)18.2507
2000's3 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kee, K1
Vujcic, S1
Merali, S1
Diegelman, P1
Kisiel, N1
Powell, CT1
Kramer, DL1
Porter, CW1
Ranger-Moore, J1
Alberts, DS1
Montironi, R1
Garcia, F1
Davis, J1
Frank, D1
Brewer, M1
Mariuzzi, GM1
Bartels, HG1
Bartels, PH1
Tanaka, T1
Kojima, T1
Hara, A1
Sawada, H1
Mori, H1
Love, RR1
Carbone, PP1
Verma, AK1
Gilmore, D1
Carey, P1
Tutsch, KD1
Pomplun, M1
Wilding, G1
Yatin, M1
Venkataraman, GM1
Marcinek, R1
Ain, KB1
Scheppach, W1
Melcher, R1
Lührs, H1
Menzel, T1
Thomas, T1
Kiang, DT1
Jänne, OA1
Thomas, TJ1
Kim, I1
Manni, A1
Lynch, J1
Hammond, JM1
Ajani, JA1
Ota, DM1
Grossie, VB1
Abbruzzese, JL1
Faintuch, JS1
Patt, YZ1
Jackson, DE1
Levin, B1
Nishioka, K1
Dunzendorfer, U1
Knöner, M1
Fujimoto, S1
Igarashi, K1
Shrestha, RD1
Miyazaki, M1
Endoh, F1
Ohta, M1
Togawa, Y1
Okui, K1
Casero, RA1
Baylin, SB1
Nelkin, BD1
Luk, GD1

Reviews

1 review available for eflornithine and Carcinoma, Anaplastic

ArticleYear
[Primary prevention of sporadic colorectal carcinoma by diet modification and drugs?].
    Der Internist, 2000, Volume: 41, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinoma; Colorectal Neoplasms; D

2000

Trials

1 trial available for eflornithine and Carcinoma, Anaplastic

ArticleYear
Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine.
    Journal of the National Cancer Institute, 1993, May-05, Volume: 85, Issue:9

    Topics: Adult; Carcinoma; Colonic Neoplasms; Eflornithine; Enzyme Induction; Female; Humans; Male; Ornithine

1993

Other Studies

10 other studies available for eflornithine and Carcinoma, Anaplastic

ArticleYear
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.
    The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26

    Topics: Acetyl Coenzyme A; Acetyltransferases; Adenosylmethionine Decarboxylase; Carcinoma; Cell Division; D

2004
Karyometry in the early detection and chemoprevention of intraepithelial lesions.
    European journal of cancer (Oxford, England : 1990), 2005, Volume: 41, Issue:13

    Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Disease Progression;

2005
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
    Cancer research, 1993, Feb-15, Volume: 53, Issue:4

    Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assay

1993
Polyamine synthesis and transport inhibition in a human anaplastic thyroid carcinoma cell line in vitro and as xenograft tumors.
    Thyroid : official journal of the American Thyroid Association, 1999, Volume: 9, Issue:8

    Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Biological Trans

1999
Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells.
    Breast cancer research and treatment, 1991, Volume: 19, Issue:3

    Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm;

1991
Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines.
    Molecular and cellular endocrinology, 1991, Volume: 78, Issue:1-2

    Topics: Breast Neoplasms; Carcinoma; Carrier Proteins; Cell Division; Eflornithine; Estradiol; Humans; Insul

1991
Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma.
    Cancer chemotherapy and pharmacology, 1990, Volume: 26, Issue:3

    Topics: Carcinoma; Colorectal Neoplasms; Drug Evaluation; Drug Tolerance; Eflornithine; Humans; Infusions, I

1990
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
    Onkologie, 1985, Volume: 8, Issue:4

    Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca

1985
Combined therapy of polyamine antimetabolites and antitumor drugs for human gastric cancer xenotransplanted into nude mice.
    The Japanese journal of surgery, 1986, Volume: 16, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcino

1986
Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
    Biochemical and biophysical research communications, 1986, Jan-29, Volume: 134, Issue:2

    Topics: Carcinoma; Carcinoma, Small Cell; Cell Cycle; Cells, Cultured; Eflornithine; Humans; Lung Neoplasms;

1986