eflornithine has been researched along with Carcinoma, Anaplastic in 12 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Excerpt | Relevance | Reference |
---|---|---|
" Small cell lung carcinoma cells die following polyamine depletion by difluoromethylornithine treatment while non-small cell lines demonstrate a typical cytostatic response." | 3.67 | Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels. ( Baylin, SB; Casero, RA; Luk, GD; Nelkin, BD, 1986) |
" DFMO has shown a dose-response effect in tumor inhibition in mice." | 2.67 | Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine. ( Carbone, PP; Carey, P; Gilmore, D; Love, RR; Pomplun, M; Tutsch, KD; Verma, AK; Wilding, G, 1993) |
" ODC gene dosage was analyzed by Southern blot hybridization and was 4- to 12-fold higher in T-47D, MDA-MB-231, and BT-20 cell lines than in the MCF-7 cell line." | 1.28 | Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells. ( Jänne, OA; Kiang, DT; Thomas, T; Thomas, TJ, 1991) |
"PA involvement in IGFBPs production by breast cancer cells is complex and may involve differential regulation of transcriptional and post-translational events." | 1.28 | Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines. ( Hammond, JM; Kim, I; Lynch, J; Manni, A, 1991) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (25.00) | 18.7374 |
1990's | 6 (50.00) | 18.2507 |
2000's | 3 (25.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kee, K | 1 |
Vujcic, S | 1 |
Merali, S | 1 |
Diegelman, P | 1 |
Kisiel, N | 1 |
Powell, CT | 1 |
Kramer, DL | 1 |
Porter, CW | 1 |
Ranger-Moore, J | 1 |
Alberts, DS | 1 |
Montironi, R | 1 |
Garcia, F | 1 |
Davis, J | 1 |
Frank, D | 1 |
Brewer, M | 1 |
Mariuzzi, GM | 1 |
Bartels, HG | 1 |
Bartels, PH | 1 |
Tanaka, T | 1 |
Kojima, T | 1 |
Hara, A | 1 |
Sawada, H | 1 |
Mori, H | 1 |
Love, RR | 1 |
Carbone, PP | 1 |
Verma, AK | 1 |
Gilmore, D | 1 |
Carey, P | 1 |
Tutsch, KD | 1 |
Pomplun, M | 1 |
Wilding, G | 1 |
Yatin, M | 1 |
Venkataraman, GM | 1 |
Marcinek, R | 1 |
Ain, KB | 1 |
Scheppach, W | 1 |
Melcher, R | 1 |
Lührs, H | 1 |
Menzel, T | 1 |
Thomas, T | 1 |
Kiang, DT | 1 |
Jänne, OA | 1 |
Thomas, TJ | 1 |
Kim, I | 1 |
Manni, A | 1 |
Lynch, J | 1 |
Hammond, JM | 1 |
Ajani, JA | 1 |
Ota, DM | 1 |
Grossie, VB | 1 |
Abbruzzese, JL | 1 |
Faintuch, JS | 1 |
Patt, YZ | 1 |
Jackson, DE | 1 |
Levin, B | 1 |
Nishioka, K | 1 |
Dunzendorfer, U | 1 |
Knöner, M | 1 |
Fujimoto, S | 1 |
Igarashi, K | 1 |
Shrestha, RD | 1 |
Miyazaki, M | 1 |
Endoh, F | 1 |
Ohta, M | 1 |
Togawa, Y | 1 |
Okui, K | 1 |
Casero, RA | 1 |
Baylin, SB | 1 |
Nelkin, BD | 1 |
Luk, GD | 1 |
1 review available for eflornithine and Carcinoma, Anaplastic
Article | Year |
---|---|
[Primary prevention of sporadic colorectal carcinoma by diet modification and drugs?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinoma; Colorectal Neoplasms; D | 2000 |
1 trial available for eflornithine and Carcinoma, Anaplastic
Article | Year |
---|---|
Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine.
Topics: Adult; Carcinoma; Colonic Neoplasms; Eflornithine; Enzyme Induction; Female; Humans; Male; Ornithine | 1993 |
10 other studies available for eflornithine and Carcinoma, Anaplastic
Article | Year |
---|---|
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.
Topics: Acetyl Coenzyme A; Acetyltransferases; Adenosylmethionine Decarboxylase; Carcinoma; Cell Division; D | 2004 |
Karyometry in the early detection and chemoprevention of intraepithelial lesions.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Disease Progression; | 2005 |
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assay | 1993 |
Polyamine synthesis and transport inhibition in a human anaplastic thyroid carcinoma cell line in vitro and as xenograft tumors.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Biological Trans | 1999 |
Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm; | 1991 |
Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines.
Topics: Breast Neoplasms; Carcinoma; Carrier Proteins; Cell Division; Eflornithine; Estradiol; Humans; Insul | 1991 |
Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma.
Topics: Carcinoma; Colorectal Neoplasms; Drug Evaluation; Drug Tolerance; Eflornithine; Humans; Infusions, I | 1990 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca | 1985 |
Combined therapy of polyamine antimetabolites and antitumor drugs for human gastric cancer xenotransplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcino | 1986 |
Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
Topics: Carcinoma; Carcinoma, Small Cell; Cell Cycle; Cells, Cultured; Eflornithine; Humans; Lung Neoplasms; | 1986 |