eflornithine has been researched along with Carcinoma, Anaplastic in 12 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Small cell lung carcinoma cells die following polyamine depletion by difluoromethylornithine treatment while non-small cell lines demonstrate a typical cytostatic response." | 3.67 | Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels. ( Baylin, SB; Casero, RA; Luk, GD; Nelkin, BD, 1986) |
| " DFMO has shown a dose-response effect in tumor inhibition in mice." | 2.67 | Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine. ( Carbone, PP; Carey, P; Gilmore, D; Love, RR; Pomplun, M; Tutsch, KD; Verma, AK; Wilding, G, 1993) |
| " ODC gene dosage was analyzed by Southern blot hybridization and was 4- to 12-fold higher in T-47D, MDA-MB-231, and BT-20 cell lines than in the MCF-7 cell line." | 1.28 | Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells. ( Jänne, OA; Kiang, DT; Thomas, T; Thomas, TJ, 1991) |
| "PA involvement in IGFBPs production by breast cancer cells is complex and may involve differential regulation of transcriptional and post-translational events." | 1.28 | Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines. ( Hammond, JM; Kim, I; Lynch, J; Manni, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kee, K | 1 |
| Vujcic, S | 1 |
| Merali, S | 1 |
| Diegelman, P | 1 |
| Kisiel, N | 1 |
| Powell, CT | 1 |
| Kramer, DL | 1 |
| Porter, CW | 1 |
| Ranger-Moore, J | 1 |
| Alberts, DS | 1 |
| Montironi, R | 1 |
| Garcia, F | 1 |
| Davis, J | 1 |
| Frank, D | 1 |
| Brewer, M | 1 |
| Mariuzzi, GM | 1 |
| Bartels, HG | 1 |
| Bartels, PH | 1 |
| Tanaka, T | 1 |
| Kojima, T | 1 |
| Hara, A | 1 |
| Sawada, H | 1 |
| Mori, H | 1 |
| Love, RR | 1 |
| Carbone, PP | 1 |
| Verma, AK | 1 |
| Gilmore, D | 1 |
| Carey, P | 1 |
| Tutsch, KD | 1 |
| Pomplun, M | 1 |
| Wilding, G | 1 |
| Yatin, M | 1 |
| Venkataraman, GM | 1 |
| Marcinek, R | 1 |
| Ain, KB | 1 |
| Scheppach, W | 1 |
| Melcher, R | 1 |
| Lührs, H | 1 |
| Menzel, T | 1 |
| Thomas, T | 1 |
| Kiang, DT | 1 |
| Jänne, OA | 1 |
| Thomas, TJ | 1 |
| Kim, I | 1 |
| Manni, A | 1 |
| Lynch, J | 1 |
| Hammond, JM | 1 |
| Ajani, JA | 1 |
| Ota, DM | 1 |
| Grossie, VB | 1 |
| Abbruzzese, JL | 1 |
| Faintuch, JS | 1 |
| Patt, YZ | 1 |
| Jackson, DE | 1 |
| Levin, B | 1 |
| Nishioka, K | 1 |
| Dunzendorfer, U | 1 |
| Knöner, M | 1 |
| Fujimoto, S | 1 |
| Igarashi, K | 1 |
| Shrestha, RD | 1 |
| Miyazaki, M | 1 |
| Endoh, F | 1 |
| Ohta, M | 1 |
| Togawa, Y | 1 |
| Okui, K | 1 |
| Casero, RA | 1 |
| Baylin, SB | 1 |
| Nelkin, BD | 1 |
| Luk, GD | 1 |
1 review available for eflornithine and Carcinoma, Anaplastic
| Article | Year |
|---|---|
[Primary prevention of sporadic colorectal carcinoma by diet modification and drugs?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Carcinoma; Colorectal Neoplasms; D | 2000 |
1 trial available for eflornithine and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine.
Topics: Adult; Carcinoma; Colonic Neoplasms; Eflornithine; Enzyme Induction; Female; Humans; Male; Ornithine | 1993 |
10 other studies available for eflornithine and Carcinoma, Anaplastic
| Article | Year |
|---|---|
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.
Topics: Acetyl Coenzyme A; Acetyltransferases; Adenosylmethionine Decarboxylase; Carcinoma; Cell Division; D | 2004 |
Karyometry in the early detection and chemoprevention of intraepithelial lesions.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Disease Progression; | 2005 |
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assay | 1993 |
Polyamine synthesis and transport inhibition in a human anaplastic thyroid carcinoma cell line in vitro and as xenograft tumors.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Biological Trans | 1999 |
Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm; | 1991 |
Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines.
Topics: Breast Neoplasms; Carcinoma; Carrier Proteins; Cell Division; Eflornithine; Estradiol; Humans; Insul | 1991 |
Evaluation of continuous-infusion alpha-difluoromethylornithine therapy for colorectal carcinoma.
Topics: Carcinoma; Colorectal Neoplasms; Drug Evaluation; Drug Tolerance; Eflornithine; Humans; Infusions, I | 1990 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca | 1985 |
Combined therapy of polyamine antimetabolites and antitumor drugs for human gastric cancer xenotransplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcino | 1986 |
Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
Topics: Carcinoma; Carcinoma, Small Cell; Cell Cycle; Cells, Cultured; Eflornithine; Humans; Lung Neoplasms; | 1986 |