eflornithine has been researched along with Cancer of Ovary in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, ovarian cancers often reacquire functional BRCA and develop resistance to PARP inhibitors." | 1.72 | Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells. ( Doyle, B; El Naggar, O; Gilmour, SK; Mariner, K, 2022) |
| "Difluoromethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC), has promising activity against various cancers and a tolerable safety profile for long-term use as a chemopreventive agent." | 1.62 | Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer. ( Hwang, WY; Kim, K; Kim, YB; No, JH; Park, WH; Suh, DH, 2021) |
| "Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy." | 1.51 | DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer. ( Bachman, KE; Baylin, SB; Brown, SM; Casero, RA; Dunworth, M; Foley, JR; Holbert, CE; Stone, ML; Travers, M; Wiehagen, KR; Zahnow, CA, 2019) |
| "The antiproliferative effects of human recombinant interferon gamma (IFN gamma) in combination with alpha-difluoromethylornithine (DFMO) or as single agents were assessed on human cell cultures derived from carcinomas of the breast (MCF-7), the ovary (EFO-27) or the kidneys (EGI-4)." | 1.29 | Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures. ( Hölzel, F; Kirchner, H; Klouche, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hwang, WY | 1 |
| Park, WH | 1 |
| Suh, DH | 1 |
| Kim, K | 1 |
| Kim, YB | 1 |
| No, JH | 1 |
| El Naggar, O | 1 |
| Doyle, B | 1 |
| Mariner, K | 1 |
| Gilmour, SK | 1 |
| Travers, M | 1 |
| Brown, SM | 1 |
| Dunworth, M | 1 |
| Holbert, CE | 1 |
| Wiehagen, KR | 1 |
| Bachman, KE | 1 |
| Foley, JR | 1 |
| Stone, ML | 1 |
| Baylin, SB | 1 |
| Casero, RA | 1 |
| Zahnow, CA | 1 |
| Klouche, M | 1 |
| Kirchner, H | 1 |
| Hölzel, F | 1 |
| Manetta, A | 1 |
| Satyaswarcoop, PG | 1 |
| Podczaski, ES | 1 |
| Hamilton, T | 1 |
| Ozols, RF | 1 |
| Mortel, R | 1 |
5 other studies available for eflornithine and Cancer of Ovary
| Article | Year |
|---|---|
Difluoromethylornithine Induces Apoptosis through Regulation of AP-1 Signaling via JNK Phosphorylation in Epithelial Ovarian Cancer.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Ovarian Epithelial; Caspase 3; Cell Line, Tumor; C | 2021 |
Difluoromethylornithine (DFMO) Enhances the Cytotoxicity of PARP Inhibition in Ovarian Cancer Cells.
Topics: Antineoplastic Agents; Eflornithine; Female; Humans; Ovarian Neoplasms; Poly(ADP-ribose) Polymerase | 2022 |
DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cystadenocarcinoma, Serous; Di | 2019 |
Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures.
Topics: Breast Neoplasms; Cell Division; Drug Synergism; Eflornithine; Female; Growth Inhibitors; Humans; In | 1994 |
Effect of alpha-difluoromethylornithine (DFMO) on the growth of human ovarian carcinoma.
Topics: Animals; Eflornithine; Female; Humans; In Vitro Techniques; Mice; Mice, Nude; Ovarian Neoplasms; Tum | 1988 |