eflornithine has been researched along with Cancer of Gastrointestinal Tract in 3 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumin treatment significantly induced spermine oxidase (SMOX) mRNA and activity, which results in the generation of hydrogen peroxide, a source of ROS." | 1.48 | Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. ( Casero, RA; Dunworth, M; Giardiello, FM; Lui, Y; Murray-Stewart, T; Woster, PM, 2018) |
| " Both marked antitumor effects and side effects were observed in mice treated at the dosage of DFMO 500 mg/kg/day and/or MGBG 50 mg/kg/day and/or MGBG 30 mg/kg/day brought about significant antitumor effects as well as less side effects." | 1.26 | [Antitumor effects of polyamine synthesis inhibitors based on major premise of treatment for human malignant tumor]. ( Fujimoto, S; Hirose, S; Igarashi, K; Okui, K; Shrestha, RD; Terao, K, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murray-Stewart, T | 1 |
| Dunworth, M | 1 |
| Lui, Y | 1 |
| Giardiello, FM | 1 |
| Woster, PM | 1 |
| Casero, RA | 1 |
| Half, E | 1 |
| Arber, N | 1 |
| Fujimoto, S | 1 |
| Shrestha, RD | 1 |
| Igarashi, K | 1 |
| Terao, K | 1 |
| Hirose, S | 1 |
| Okui, K | 1 |
1 review available for eflornithine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Chemoprevention of gastrointestinal neoplasia.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemoprevention; Col | 2013 |
2 other studies available for eflornithine and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Antineoplastic Agents; Biosynthetic Pathways; | 2018 |
[Antitumor effects of polyamine synthesis inhibitors based on major premise of treatment for human malignant tumor].
Topics: Animals; Cell Division; Drug Synergism; Drug Therapy, Combination; Eflornithine; Gastrointestinal Ne | 1982 |