eflornithine has been researched along with Cancer of Esophagus in 8 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because esophageal cancer initiation by NMBA is very rapid in ZD rats, this study determined whether DFMO is effective in preventing esophageal carcinogenesis when administered after the establishment of a carcinogenic environment." | 1.31 | Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats. ( Fong, LY; Magee, PN; Nguyen, VT; Pegg, AE, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Half, E | 1 |
| Arber, N | 1 |
| Akiyama, J | 1 |
| Alexandre, L | 1 |
| Baruah, A | 1 |
| Buttar, N | 1 |
| Chandra, R | 1 |
| Clark, AB | 1 |
| Hart, AR | 1 |
| Hawk, E | 1 |
| Kandioler, D | 1 |
| Kappel, S | 1 |
| Krishnadath, SK | 1 |
| Sharma, A | 1 |
| Singh, I | 1 |
| Straub, D | 1 |
| Triadafilopoulos, G | 1 |
| Umar, A | 1 |
| Wolf, B | 1 |
| Chen, X | 1 |
| Li, N | 1 |
| Wang, S | 1 |
| Hong, J | 1 |
| Fang, M | 1 |
| Yousselfson, J | 1 |
| Yang, P | 1 |
| Newman, RA | 1 |
| Lubet, RA | 1 |
| Yang, CS | 1 |
| Wax, A | 1 |
| Yang, C | 1 |
| Müller, MG | 1 |
| Nines, R | 1 |
| Boone, CW | 1 |
| Steele, VE | 1 |
| Stoner, GD | 1 |
| Dasari, RR | 1 |
| Feld, MS | 1 |
| Warrell, RP | 1 |
| Burchenal, JH | 1 |
| Fong, LY | 2 |
| Pegg, AE | 2 |
| Magee, PN | 2 |
| Nguyen, VT | 1 |
| Garewal, HS | 1 |
3 reviews available for eflornithine and Cancer of Esophagus
| Article | Year |
|---|---|
Chemoprevention of gastrointestinal neoplasia.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemoprevention; Col | 2013 |
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
Chemoprevention of Barrett's esophagus and oral leukoplakia.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Barrett Esophagus; Biomarkers; Carcinoma, Squamous Cell; Ca | 1992 |
2 trials available for eflornithine and Cancer of Esophagus
| Article | Year |
|---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Tri | 1983 |
Chemoprevention of Barrett's esophagus and oral leukoplakia.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Barrett Esophagus; Biomarkers; Carcinoma, Squamous Cell; Ca | 1992 |
5 other studies available for eflornithine and Cancer of Esophagus
| Article | Year |
|---|---|
Strategy for prevention of cancers of the esophagus.
Topics: Animals; Antineoplastic Agents; Barrett Esophagus; Biomarkers, Tumor; Cell Transformation, Neoplasti | 2014 |
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Body Weight; Cyclooxygenase 2 | 2002 |
In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Eflornithine; Epithelial Cells; Esophageal Ne | 2003 |
Alpha-difluoromethylornithine inhibits N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in zinc-deficient rats: effects on esophageal cell proliferation and apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Biogenic Polyamines; Carcin | 1998 |
Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats.
Topics: Analysis of Variance; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cell Divisi | 2001 |