eflornithine has been researched along with Breast Neoplasms in 58 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although tamoxifen appears to markedly reduce breast cancer risk in women with a prior diagnosis of atypical hyperplasia or in situ carcinoma, it is not clear what other groups of women receive substantial benefit." | 8.81 | Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. ( Fabian, CJ; Kimler, BF, 2001) |
| " In estrogen-responsive ZR-75-1 human breast cancer cells, which display low polyamine biosynthetic activity, putrescine and spermidine were internalized with high affinity (Km = 3." | 7.69 | Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells. ( Lessard, M; Poulin, R; Singh, SM; Zhao, C, 1995) |
| "In 4 different human breast cancer cell lines (ZR-75-1, T47-D, MCF-7, and MDA-MB-231), relative growth sensitivity to C-DAP was inversely related to the extent of spermidine accumulation caused by spermine synthase inhibition, suggesting that spermidine overaccumulation can functionally replace spermine." | 5.29 | Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells. ( Huber, M; Poulin, R, 1995) |
| "Although tamoxifen appears to markedly reduce breast cancer risk in women with a prior diagnosis of atypical hyperplasia or in situ carcinoma, it is not clear what other groups of women receive substantial benefit." | 4.81 | Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention. ( Fabian, CJ; Kimler, BF, 2001) |
| " Experiments were carried out on the trastuzumab-resistant human epidermal growth factor receptor 2-overexpressing breast cancer cell line JIMT-1 to unravel the chemotherapeutic effects of the polyamine analogue [1N,12N]bis(ethyl)-cis-6,7-dehydrospermine (PG11047) and of the polyamine biosynthetic inhibitor 2-difluoromethylornithine (DFMO) on the CD44+CD24- CSC population." | 3.76 | Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047. ( Cirenajwis, H; Hegardt, C; Honeth, G; Marton, LJ; Oredsson, SM; Smiljanic, S, 2010) |
| " In estrogen-responsive ZR-75-1 human breast cancer cells, which display low polyamine biosynthetic activity, putrescine and spermidine were internalized with high affinity (Km = 3." | 3.69 | Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells. ( Lessard, M; Poulin, R; Singh, SM; Zhao, C, 1995) |
| "Previous studies have shown that natural polyamines-putrescine, spermidine, and spermine-play a key role in the mechanism of action of estrogens in breast cancer." | 3.69 | Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications. ( Thomas, T; Thomas, TJ, 1994) |
| "These experiments were designed to test polyamine (PA) involvement in the secretion and action of transforming growth factor alpha (TGF-alpha) in hormone responsive MCF-7 breast cancer cells in liquid culture." | 3.68 | Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture. ( Demers, L; Kim, I; Lynch, J; Manni, A, 1991) |
| " In the estradiol-responsive human breast cancer cell line, T-47D clone 11, estradiol (10(-10) M) was able to stimulate cell proliferation and the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the biosynthesis of polyamines." | 3.67 | Intrinsic and extrinsic factors in estrogen action in human breast cancer: role of polyamines and pituitary factors. ( Dembinski, TC; Leung, CK; Lima, G; Shiu, RP, 1986) |
| " The dosage of PXM 10 mg q." | 2.69 | Phase I chemoprevention study of piroxicam and alpha-difluoromethylornithine. ( Blair, IA; Carbone, PP; Douglas, JA; Larson, PO; Pomplun, M; Tutsch, KD; Verma, AK, 1998) |
| "Though hyperglycemia has been considered as a fuel for growth of cancer cells, pathways leading to this condition are still under investigation." | 1.62 | Hyperglycemic conditions proliferate triple negative breast cancer cells: role of ornithine decarboxylase. ( Capellen, CC; Casero, RA; Chandra, S; Dunworth, M; Morwitzer, MJ; Ortega-Rodas, J; Tofilau, HMN, 2021) |
| "Their biosynthesis is upregulated in breast cancer and they contribute to disease progression." | 1.62 | Characterising the Response of Human Breast Cancer Cells to Polyamine Modulation. ( Akinyele, O; Wallace, HM, 2021) |
| "The number and incidence of lung metastases were determined." | 1.33 | Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment. ( Bond, JS; Demers, LM; DiGirolamo, DJ; Manni, A; Matters, G; Phadke, PA; Richert, MM; Washington, S; Welch, DR, 2005) |
| " Treatment of cells with a second inhibitor of polyamine biosynthesis, the S-adenosylmethionine decarboxylase (SAMDC) inhibitor SAM486A, also resulted in a dosage dependent decrease in meprin alpha and MMP-7 mRNA." | 1.33 | Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. ( Bond, JS; Manni, A; Matters, GL, 2005) |
| " We found that DFMO administration to MCF-10A cells increased EGF-R mRNA and protein levels in a dose-response fashion, while HER-2neu expression was not affected." | 1.31 | Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal growth factor receptor in human breast epithelial cells in culture. ( Demers, L; Manni, A; Mauger, D; Trout, D; Verderame, MF; Washington, S, 2001) |
| "The antiproliferative effects of human recombinant interferon gamma (IFN gamma) in combination with alpha-difluoromethylornithine (DFMO) or as single agents were assessed on human cell cultures derived from carcinomas of the breast (MCF-7), the ovary (EFO-27) or the kidneys (EGI-4)." | 1.29 | Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures. ( Hölzel, F; Kirchner, H; Klouche, M, 1994) |
| "In 4 different human breast cancer cell lines (ZR-75-1, T47-D, MCF-7, and MDA-MB-231), relative growth sensitivity to C-DAP was inversely related to the extent of spermidine accumulation caused by spermine synthase inhibition, suggesting that spermidine overaccumulation can functionally replace spermine." | 1.29 | Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells. ( Huber, M; Poulin, R, 1995) |
| " ODC gene dosage was analyzed by Southern blot hybridization and was 4- to 12-fold higher in T-47D, MDA-MB-231, and BT-20 cell lines than in the MCF-7 cell line." | 1.28 | Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells. ( Jänne, OA; Kiang, DT; Thomas, T; Thomas, TJ, 1991) |
| "PA involvement in IGFBPs production by breast cancer cells is complex and may involve differential regulation of transcriptional and post-translational events." | 1.28 | Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines. ( Hammond, JM; Kim, I; Lynch, J; Manni, A, 1991) |
| "CAL 18 A cells, derived from a breast carcinoma, were incubated with alpha-difluoromethylornithine (DFMO)--a specific and irreversible inhibitor of ornithine decarboxylase (ODC)--at a 1 mM or 10-mM concentration for either 1 hr or 24 hr and irradiated thereafter." | 1.27 | Radiosensitization of human tumor cells by alpha-difluoromethylornithine. ( Bouclier, M; Courdi, A; Lalanne, CM; Milano, G, 1986) |
| " A dose-response curve was developed for each interferon in which the maximum dose applied gave at least 30% growth inhibition of control values after 96-128 h of continuous exposure." | 1.27 | The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines. ( Harvey, HA; Leitzel, KE; Lipton, A; Pegg, AE; Wolf, LM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (25.86) | 18.7374 |
| 1990's | 18 (31.03) | 18.2507 |
| 2000's | 20 (34.48) | 29.6817 |
| 2010's | 3 (5.17) | 24.3611 |
| 2020's | 2 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Capellen, CC | 1 |
| Ortega-Rodas, J | 1 |
| Morwitzer, MJ | 1 |
| Tofilau, HMN | 1 |
| Dunworth, M | 1 |
| Casero, RA | 2 |
| Chandra, S | 1 |
| Akinyele, O | 1 |
| Wallace, HM | 1 |
| Woster, PM | 1 |
| Izbicka, E | 1 |
| Streeper, RT | 1 |
| Yeh, IT | 1 |
| Pressley, O | 1 |
| Grant, M | 1 |
| Andrews, JV | 1 |
| Kuhn, J | 1 |
| O'Shaughnessy, J | 1 |
| Cirenajwis, H | 1 |
| Smiljanic, S | 1 |
| Honeth, G | 1 |
| Hegardt, C | 1 |
| Marton, LJ | 3 |
| Oredsson, SM | 1 |
| Chiaviello, A | 1 |
| Paciello, I | 1 |
| Veneziani, BM | 1 |
| Palumbo, G | 1 |
| Aloj, SM | 1 |
| Fabian, CJ | 4 |
| Kimler, BF | 4 |
| Brady, DA | 1 |
| Mayo, MS | 1 |
| Chang, CH | 1 |
| Ferraro, JA | 1 |
| Zalles, CM | 1 |
| Stanton, AL | 1 |
| Masood, S | 1 |
| Grizzle, WE | 1 |
| Boyd, NF | 1 |
| Arneson, DW | 1 |
| Johnson, KA | 1 |
| Zaletok, S | 1 |
| Alexandrova, N | 1 |
| Berdynskykh, N | 1 |
| Ignatenko, N | 1 |
| Gogol, S | 1 |
| Orlovsky, O | 1 |
| Tregubova, N | 1 |
| Gerner, E | 1 |
| Chekhun, V | 1 |
| Manni, A | 19 |
| Washington, S | 9 |
| Mauger, D | 5 |
| Hackett, DA | 1 |
| Verderame, MF | 8 |
| Ranger-Moore, J | 1 |
| Alberts, DS | 1 |
| Montironi, R | 1 |
| Garcia, F | 1 |
| Davis, J | 1 |
| Frank, D | 1 |
| Brewer, M | 1 |
| Mariuzzi, GM | 1 |
| Bartels, HG | 1 |
| Bartels, PH | 1 |
| Hu, X | 3 |
| Griffith, JW | 2 |
| Bruggeman, R | 1 |
| Demers, LM | 4 |
| Richert, MM | 1 |
| Phadke, PA | 1 |
| Matters, G | 1 |
| DiGirolamo, DJ | 1 |
| Bond, JS | 2 |
| Welch, DR | 2 |
| Matters, GL | 1 |
| Xu, H | 2 |
| Rager, T | 1 |
| Kimball, SR | 1 |
| Jefferson, LS | 1 |
| Klouche, M | 1 |
| Kirchner, H | 1 |
| Hölzel, F | 1 |
| Lessard, M | 1 |
| Zhao, C | 1 |
| Singh, SM | 1 |
| Poulin, R | 3 |
| Huber, M | 2 |
| Wechter, R | 1 |
| Wei, L | 1 |
| Heitjan, D | 1 |
| Demers, L | 7 |
| Thomas, T | 5 |
| Thomas, TJ | 4 |
| Das, B | 2 |
| Rao, AR | 1 |
| Madhubala, R | 2 |
| Carbone, PP | 1 |
| Douglas, JA | 1 |
| Larson, PO | 1 |
| Verma, AK | 1 |
| Blair, IA | 1 |
| Pomplun, M | 1 |
| Tutsch, KD | 1 |
| Shah, N | 1 |
| Klinge, CM | 1 |
| Faaland, CA | 1 |
| Adihkarakunnathu, S | 1 |
| Gallo, MA | 1 |
| O'Shaughnessy, JA | 1 |
| Jones, SE | 1 |
| Arseneau, J | 1 |
| Khandelwal, P | 1 |
| George, T | 1 |
| Gersh, R | 1 |
| Bacus, JW | 1 |
| Boone, CW | 1 |
| Bacus, JV | 1 |
| Follen, M | 1 |
| Kelloff, GJ | 1 |
| Kagan, V | 1 |
| Lippman, SM | 1 |
| Vig, M | 1 |
| Khurana, KK | 1 |
| Wallace, DD | 1 |
| Klemp, J | 1 |
| Brady, D | 1 |
| Frank, TS | 1 |
| Weeks, RS | 1 |
| Vanderwerf, SM | 1 |
| Carlson, CL | 1 |
| Burns, MR | 1 |
| O'Day, CL | 1 |
| Cai, F | 1 |
| Devens, BH | 1 |
| Webb, HK | 1 |
| Herbert, BS | 1 |
| Wright, AC | 1 |
| Passons, CM | 1 |
| Wright, WE | 1 |
| Ali, IU | 1 |
| Kopelovich, L | 1 |
| Shay, JW | 1 |
| Trout, D | 1 |
| Samant, RS | 1 |
| Badger, B | 1 |
| Martel, J | 1 |
| Kiang, DT | 2 |
| Jänne, OA | 1 |
| Kim, I | 2 |
| Lynch, J | 2 |
| Hammond, JM | 1 |
| Cohen, FJ | 1 |
| Glikman, P | 2 |
| Bartholomew, M | 3 |
| Glikman, PL | 1 |
| Kyriakidis, DA | 1 |
| Kortsaris, A | 1 |
| Marth, C | 1 |
| Kirchebner, P | 1 |
| Daxenbichler, G | 1 |
| Horn, Y | 2 |
| Spigel, L | 1 |
| Umemoto, S | 1 |
| Shiu, RP | 2 |
| Lima, G | 2 |
| Leung, CK | 1 |
| Dembinski, TC | 1 |
| Hoggard, N | 1 |
| Green, CD | 1 |
| Courdi, A | 1 |
| Milano, G | 1 |
| Bouclier, M | 1 |
| Lalanne, CM | 1 |
| Kendra, KL | 1 |
| Katzenellenbogen, BS | 1 |
| Schechter, PJ | 1 |
| Wolf, LM | 1 |
| Leitzel, KE | 1 |
| Pegg, AE | 1 |
| Harvey, HA | 1 |
| Lipton, A | 1 |
| Malt, RA | 1 |
| Kingsnorth, AN | 1 |
| Lamuraglia, GM | 1 |
| Lacaine, F | 1 |
| Ross, JS | 1 |
4 reviews available for eflornithine and Breast Neoplasms
| Article | Year |
|---|---|
Recent advances in the development of polyamine analogues as antitumor agents.
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Breast Neoplasms; DNA; Drug Discovery; Eflornit | 2009 |
Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.
Topics: Aneuploidy; Angiogenesis Inhibitors; Anticarcinogenic Agents; Apoptosis; Aromatase Inhibitors; Breas | 2001 |
Polyamines and hormonal control of breast cancer growth.
Topics: Animals; Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Female; Humans; Mammary Neoplasms | 1989 |
Chemoprevention and chemotherapy by inhibition of ornithine decarboxylase activity and polyamine synthesis: colonic, pancreatic, mammary, and renal carcinomas.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Eflornithine; Fe | 1985 |
6 trials available for eflornithine and Breast Neoplasms
| Article | Year |
|---|---|
A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers.
Topics: Administration, Oral; Antineoplastic Agents; Biomarkers, Tumor; Biopsy, Needle; Breast Neoplasms; Do | 2002 |
Phase I chemoprevention study of piroxicam and alpha-difluoromethylornithine.
Topics: Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Biopsy; Breast Neoplasms; Colonic Neoplasms | 1998 |
Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Eflornithine; Female; Humans; Middle Aged; Neo | 1999 |
Incidence of BRCA1/2 germ line alterations in a high risk cohort participating in a phase II chemoprevention trial.
Topics: Adult; Antineoplastic Agents; BRCA2 Protein; Breast Neoplasms; Cohort Studies; Eflornithine; Female; | 2000 |
Urinary polyamine levels in cancer patients treated with D,L-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Eflornithine; Fem | 1989 |
Phase I-II clinical trial with alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Eflornithin | 1987 |
48 other studies available for eflornithine and Breast Neoplasms
| Article | Year |
|---|---|
Hyperglycemic conditions proliferate triple negative breast cancer cells: role of ornithine decarboxylase.
Topics: Breast Neoplasms; Eflornithine; Female; Humans; Hyperglycemia; Ornithine Decarboxylase; Ornithine De | 2021 |
Characterising the Response of Human Breast Cancer Cells to Polyamine Modulation.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Eflornithine; Female; Gene Ex | 2021 |
Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Intraductal, Nonin | 2010 |
Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; | 2010 |
Cells derived from normal or cancer breast tissue exhibit different growth properties when deprived of arginine.
Topics: Arginine; Breast; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Ce | 2012 |
Role of polyamines in the function of nuclear transcription factor NF-kappaB in breast cancer cells.
Topics: Animals; Blotting, Western; Breast Neoplasms; Carcinoma 256, Walker; Cell Line, Tumor; Cell Nucleus; | 2004 |
Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells.
Topics: Breast Neoplasms; Eflornithine; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Mit | 2004 |
Karyometry in the early detection and chemoprevention of intraepithelial lesions.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Disease Progression; | 2005 |
Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells.
Topics: Amidines; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Proli | 2005 |
Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Eflornithine; Fe | 2005 |
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
Topics: Amidines; Antineoplastic Agents; Breast Neoplasms; Down-Regulation; Eflornithine; Enzyme Inhibitors; | 2005 |
Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells.
Topics: Breast Neoplasms; Butadienes; Calcium-Binding Proteins; Cell Cycle; Cell Growth Processes; Cell Line | 2005 |
Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Eflorn | 2008 |
Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Eflornithine; Enzyme Inhibitors; | 2007 |
Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Eflornithine; Hepatocyte Growth Factor; | 2008 |
Antiproliferative effects of interferon gamma in combination with alpha-difluoromethylornithine on human carcinoma cell cultures.
Topics: Breast Neoplasms; Cell Division; Drug Synergism; Eflornithine; Female; Growth Inhibitors; Humans; In | 1994 |
Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells.
Topics: Biological Transport; Breast Neoplasms; Cell Division; Cell Line; Cycloheximide; Drug Synergism; Efl | 1995 |
Antiproliferative effect of spermine depletion by N-cyclohexyl-1,3-diaminopropane in human breast cancer cells.
Topics: Biogenic Polyamines; Breast Neoplasms; Cell Division; Cyclohexylamines; Eflornithine; Humans; Spermi | 1995 |
Phenotypic features of breast cancer cells overexpressing ornithine-decarboxylase.
Topics: Breast Neoplasms; Clone Cells; Eflornithine; Ornithine Decarboxylase; Phenotype; Polyamines; Putresc | 1995 |
Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Female; Flow Cytometry; G1 Phas | 1994 |
Regulation of cyclin B1 by estradiol and polyamines in MCF-7 breast cancer cells.
Topics: Biogenic Polyamines; Breast Neoplasms; Cell Cycle; Cyclins; Eflornithine; Estradiol; Female; Gene Ex | 1994 |
Permissive role of polyamines in the cooperative action of estrogens and insulin or insulin-like growth factor I on human breast cancer cell growth.
Topics: Base Sequence; Biogenic Polyamines; Breast Neoplasms; Cell Cycle; Cell Division; Eflornithine; Estra | 1996 |
Difluoromethylornithine antagonizes taxol cytotoxicity in MCF-7 human breast cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Sur | 1997 |
Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells.
Topics: Amidines; Animals; Biogenic Polyamines; Breast Neoplasms; Cell Division; Eflornithine; Estradiol; Fe | 1999 |
Image morphometric nuclear grading of intraepithelial neoplastic lesions with applications to cancer chemoprevention trials.
Topics: Antineoplastic Agents; Biopsy; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Ductal, Breast; Cell | 1999 |
Isolation and characterization of human breast adenocarcinoma cells made resistant to alpha-difluoromethylornithine.
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Resi | 2000 |
Breast cancer chemoprevention trials using the fine-needle aspiration model.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Biopsy, Needle; Breast; Breast Neoplasms; Clinical Protoco | 2000 |
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine; | 2000 |
Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells.
Topics: Antineoplastic Agents; Breast; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cel | 2001 |
Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal growth factor receptor in human breast epithelial cells in culture.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Line; Dose-Resp | 2001 |
Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells.
Topics: Animals; Biogenic Polyamines; Blotting, Northern; Breast Neoplasms; Collagen; Dose-Response Relation | 2002 |
Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice.
Topics: Animals; Breast Neoplasms; Cell Division; Drug Resistance; Drug Screening Assays, Antitumor; Eflorni | 1992 |
Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm; | 1991 |
Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines.
Topics: Breast Neoplasms; Carcinoma; Carrier Proteins; Cell Division; Eflornithine; Estradiol; Humans; Insul | 1991 |
Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture.
Topics: Breast Neoplasms; Cell Division; Eflornithine; Estrogens; Humans; In Vitro Techniques; Neoplasms, Ho | 1991 |
Interactions between growth factor secretion and polyamines in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Dose-Response Relationship, Drug; Eflornithine; Estrogen Antagonists; Female; Huma | 1990 |
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Transformation, Neoplastic; Eflornithine; Estradiol; | 1990 |
Effects of human interferon and alpha-difluoromethylornithine on T47D cells.
Topics: Breast Neoplasms; Cell Line; DNA; Drug Synergism; Eflornithine; Humans; Interferons; Ornithine Decar | 1986 |
The role of polyamines in interferon and retinoic acid mediated synergistic antiproliferative action.
Topics: Biogenic Polyamines; Breast Neoplasms; Cell Division; Eflornithine; Female; Humans; Interferon-gamma | 1989 |
Polyamine involvement in the growth of hormone-responsive and -resistant human breast cancer cells in culture.
Topics: Biogenic Polyamines; Breast Neoplasms; Cell Count; Dose-Response Relationship, Drug; Eflornithine; F | 1989 |
[Antitumor effect of alpha-difluoromethylornithine (DFMO) changes in ornithine decarboxylase (ODC) activity and polyamine (PA) levels in human tumor transplanted into nude mice].
Topics: Animals; Biogenic Polyamines; Breast Neoplasms; Colonic Neoplasms; Drug Screening Assays, Antitumor; | 1989 |
Intrinsic and extrinsic factors in estrogen action in human breast cancer: role of polyamines and pituitary factors.
Topics: Animals; Breast Neoplasms; Cell Line; Drug Synergism; Eflornithine; Estrogens; Female; Humans; Mice; | 1986 |
Polyamines and growth regulation of cultured human breast cancer cells by 17 beta-oestradiol.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Humans; Insulin; Ornithine; Orn | 1986 |
Radiosensitization of human tumor cells by alpha-difluoromethylornithine.
Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Survival; DNA Repair; DNA, Neoplasm; Eflornithine; | 1986 |
An evaluation of the involvement of polyamines in modulating MCF-7 human breast cancer cell proliferation and progesterone receptor levels by estrogen and antiestrogen.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Humans; Neoplasms, Hormone-Depe | 1987 |
Additive growth-inhibitory effects of DL-alpha-difluoromethylornithine and antiestrogens on MCF-7 breast cancer cell line.
Topics: Breast Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Eflornithine; Estrogen Antagonis | 1987 |
Role of polyamines in estradiol-induced growth of human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Eflornithine; Estradiol; Female; Humans; Ornithine; Ornithine Decarboxy | 1985 |
The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Drug Interactions; | 1985 |