eflornithine has been researched along with Brain Ischemia in 8 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We produced cerebral ischemia in rats and measured BBB opening 6 h later as the increase in regional transfer constants (Ki) for blood to brain diffusion of [3H]sucrose." | 1.30 | Lack of evidence for direct involvement of NMDA receptors or polyamines in blood-brain barrier injury after cerebral ischemia in rats. ( Palmer, GC; Preston, E; Webster, J, 1998) |
| "We have shown that transient cerebral ischemia gives rise to increased ODC mRNA and enzyme activity in the gerbil brain." | 1.29 | Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage. ( Dempsey, RJ; Hu, Y; Kindy, MS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (87.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wan, X | 1 |
| Jiang, B | 1 |
| Liu, YS | 1 |
| Liu, HW | 1 |
| Wu, GY | 1 |
| Chen, R | 1 |
| Rao, AM | 1 |
| Başkaya, MK | 1 |
| Maley, ME | 1 |
| Prasad, MR | 1 |
| Dempsey, RJ | 3 |
| Kindy, MS | 1 |
| Hu, Y | 1 |
| Schmitz, MP | 1 |
| Combs, DJ | 1 |
| Hall, NC | 1 |
| Carney, JM | 1 |
| Cheng, M | 1 |
| Butterfield, DA | 1 |
| Johnson, TD | 1 |
| Preston, E | 1 |
| Webster, J | 1 |
| Palmer, GC | 1 |
| Sauer, D | 1 |
| Martin, P | 1 |
| Allegrini, PR | 1 |
| Bernasconi, R | 1 |
| Amacker, H | 1 |
| Fagg, GE | 1 |
1 review available for eflornithine and Brain Ischemia
| Article | Year |
|---|---|
Polyamines and cerebral ischemia.
Topics: Adenosylmethionine Decarboxylase; Animals; Barbiturates; Biogenic Polyamines; Brain Injuries; Brain | 1998 |
7 other studies available for eflornithine and Brain Ischemia
| Article | Year |
|---|---|
[Effect of alpha-difluoromethylornithine on the expression of ODC mRNA in the cortex and hippocampus in rats after cerebral ischemia reperfusion].
Topics: Animals; Brain Ischemia; Cerebral Cortex; Eflornithine; Hippocampus; Male; Ornithine Decarboxylase; | 2005 |
Ornithine decarboxylase activity and edema formation in cerebral ischemia of conscious gerbils.
Topics: Animals; Brain Edema; Brain Ischemia; Eflornithine; Gerbillinae; Male; Ornithine Decarboxylase; Spec | 1995 |
Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cell Survival; Eflornithine; Gerbillinae; Male; Neur | 1994 |
Difluoromethylornithine decreases postischemic brain edema and blood-brain barrier breakdown.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Cats; Cerebral Infarction; Eflornithine; | 1993 |
Prevention of ischemia/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-alpha-phenylnitrone and difluoromethylornithine.
Topics: Analysis of Variance; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Eflornithine; Free | 1995 |
Lack of evidence for direct involvement of NMDA receptors or polyamines in blood-brain barrier injury after cerebral ischemia in rats.
Topics: Animals; Biogenic Polyamines; Blood-Brain Barrier; Brain Ischemia; Dizocilpine Maleate; Eflornithine | 1998 |
Differing effects of alpha-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cerebral Infarction; Eflornithine; Magn | 1992 |