eflornithine has been researched along with Brain Injuries in 7 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosi, S | 1 |
| Ferguson, R | 1 |
| Fishman, K | 1 |
| Allen, A | 1 |
| Raber, J | 1 |
| Fike, JR | 1 |
| Dienel, GA | 1 |
| Cruz, NF | 1 |
| Trout, JJ | 1 |
| Lu, CY | 2 |
| Goldstone, AD | 2 |
| Sahgal, S | 1 |
| Başkaya, MK | 1 |
| Rao, AM | 1 |
| Puckett, L | 1 |
| Prasad, MR | 1 |
| Dempsey, RJ | 1 |
| Johnson, TD | 1 |
| Zini, I | 1 |
| Zoli, M | 1 |
| Grimaldi, R | 1 |
| Pich, EM | 1 |
| Biagini, G | 1 |
| Fuxe, K | 1 |
| Agnati, LF | 1 |
| Koenig, H | 1 |
1 review available for eflornithine and Brain Injuries
| Article | Year |
|---|---|
Polyamines and cerebral ischemia.
Topics: Adenosylmethionine Decarboxylase; Animals; Barbiturates; Biogenic Polyamines; Brain Injuries; Brain | 1998 |
6 other studies available for eflornithine and Brain Injuries
| Article | Year |
|---|---|
The polyamine inhibitor alpha-difluoromethylornithine modulates hippocampus-dependent function after single and combined injuries.
Topics: Animals; Brain Injuries; Cognition; Cognition Disorders; Eflornithine; Enzyme Inhibitors; Hippocampu | 2012 |
Induction of brain ornithine decarboxylase during recovery from metabolic, mechanical, thermal, or chemical injury.
Topics: Animals; Brain; Brain Injuries; Dactinomycin; Eflornithine; Hot Temperature; Hypoxia; Injections, In | 1984 |
Polyamines and NMDA receptors modulate pericapillary astrocyte swelling following cerebral cryo-injury in the rat.
Topics: Animals; Astrocytes; Biogenic Polyamines; Brain; Brain Injuries; Capillaries; Cold Temperature; Dizo | 1995 |
Effect of difluoromethylornithine treatment on regional ornithine decarboxylase activity and edema formation after experimental brain injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Edema; Eflornithine; Male; Ornithine Decarboxylase; | 1996 |
Evidence for a role of neosynthetized putrescine in the increase of glial fibrillary acidic protein immunoreactivity induced by a mechanical lesion in the rat brain.
Topics: Animals; Astrocytes; Brain Injuries; Corpus Striatum; Eflornithine; Glial Fibrillary Acidic Protein; | 1990 |
Blood-brain barrier breakdown in cold-injured brain is linked to a biphasic stimulation of ornithine decarboxylase activity and polyamine synthesis: both are coordinately inhibited by verapamil, dexamethasone, and aspirin.
Topics: Animals; Aspirin; Blood-Brain Barrier; Brain; Brain Injuries; Cold Temperature; Cycloheximide; Dacti | 1989 |