eflornithine has been researched along with Brain Disorders in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The treatment of late-stage human African trypanosomiasis is complicated by a post-treatment reactive encephalopathy, also referred to as a 'reactive arsenical encephalopathy', that may be fatal." | 1.30 | The role of the polyamine inhibitor eflornithine in the neuropathogenesis of experimental murine African trypanosomiasis. ( Burke, JM; Gichuki, CW; Hunter, CA; Jennings, FW; Kennedy, PG; Murray, M; Rodgers, J, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jennings, FW | 1 |
| Gichuki, CW | 1 |
| Kennedy, PG | 1 |
| Rodgers, J | 1 |
| Hunter, CA | 1 |
| Murray, M | 1 |
| Burke, JM | 1 |
| Paschen, W | 1 |
| Kish, SJ | 1 |
| Wilson, JM | 1 |
| Fletcher, PJ | 1 |
| Onyeyili, PA | 1 |
| Onwualu, JE | 1 |
1 review available for eflornithine and Brain Disorders
| Article | Year |
|---|---|
Polyamine metabolism in different pathological states of the brain.
Topics: Adenosylmethionine Decarboxylase; Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Diseas | 1992 |
3 other studies available for eflornithine and Brain Disorders
| Article | Year |
|---|---|
The role of the polyamine inhibitor eflornithine in the neuropathogenesis of experimental murine African trypanosomiasis.
Topics: Animals; Brain; Brain Diseases; Diminazene; Eflornithine; Female; Mice; Mice, Inbred Strains; Polyam | 1997 |
The polyamine synthesis inhibitor alpha-difluoromethylornithine is neuroprotective against N-methyl-D-aspartate-induced brain damage in vivo.
Topics: Animals; Biogenic Polyamines; Brain; Brain Diseases; Eflornithine; Models, Biological; N-Methylaspar | 1991 |
Efficacy of combination of DFMO and diminazene aceturate in the treatment of late stage Trypanosoma brucei brucei infection in rats.
Topics: Animals; Brain Diseases; Diminazene; Drug Synergism; Drug Therapy, Combination; Eflornithine; Female | 1991 |