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eflornithine and Brain Disorders

eflornithine has been researched along with Brain Disorders in 4 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"The treatment of late-stage human African trypanosomiasis is complicated by a post-treatment reactive encephalopathy, also referred to as a 'reactive arsenical encephalopathy', that may be fatal."1.30The role of the polyamine inhibitor eflornithine in the neuropathogenesis of experimental murine African trypanosomiasis. ( Burke, JM; Gichuki, CW; Hunter, CA; Jennings, FW; Kennedy, PG; Murray, M; Rodgers, J, 1997)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jennings, FW1
Gichuki, CW1
Kennedy, PG1
Rodgers, J1
Hunter, CA1
Murray, M1
Burke, JM1
Paschen, W1
Kish, SJ1
Wilson, JM1
Fletcher, PJ1
Onyeyili, PA1
Onwualu, JE1

Reviews

1 review available for eflornithine and Brain Disorders

ArticleYear
Polyamine metabolism in different pathological states of the brain.
    Molecular and chemical neuropathology, 1992, Volume: 16, Issue:3

    Topics: Adenosylmethionine Decarboxylase; Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Diseas

1992

Other Studies

3 other studies available for eflornithine and Brain Disorders

ArticleYear
The role of the polyamine inhibitor eflornithine in the neuropathogenesis of experimental murine African trypanosomiasis.
    Neuropathology and applied neurobiology, 1997, Volume: 23, Issue:3

    Topics: Animals; Brain; Brain Diseases; Diminazene; Eflornithine; Female; Mice; Mice, Inbred Strains; Polyam

1997
The polyamine synthesis inhibitor alpha-difluoromethylornithine is neuroprotective against N-methyl-D-aspartate-induced brain damage in vivo.
    European journal of pharmacology, 1991, Dec-10, Volume: 209, Issue:1-2

    Topics: Animals; Biogenic Polyamines; Brain; Brain Diseases; Eflornithine; Models, Biological; N-Methylaspar

1991
Efficacy of combination of DFMO and diminazene aceturate in the treatment of late stage Trypanosoma brucei brucei infection in rats.
    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1991, Volume: 42, Issue:2

    Topics: Animals; Brain Diseases; Diminazene; Drug Synergism; Drug Therapy, Combination; Eflornithine; Female

1991