eflornithine has been researched along with Brain Damage, Chronic in 2 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have shown that transient cerebral ischemia gives rise to increased ODC mRNA and enzyme activity in the gerbil brain." | 1.29 | Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage. ( Dempsey, RJ; Hu, Y; Kindy, MS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kindy, MS | 1 |
| Hu, Y | 1 |
| Dempsey, RJ | 1 |
| de Vera, N | 1 |
| Artigas, F | 1 |
| Serratosa, J | 1 |
| MartÃnez, E | 1 |
2 other studies available for eflornithine and Brain Damage, Chronic
| Article | Year |
|---|---|
Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cell Survival; Eflornithine; Gerbillinae; Male; Neur | 1994 |
Changes in polyamine levels in rat brain after systemic kainic acid administration: relationship to convulsant activity and brain damage.
Topics: Animals; Body Weight; Brain; Brain Damage, Chronic; Eflornithine; Injections, Intraperitoneal; Kaini | 1991 |