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eflornithine and Brain Damage, Chronic

eflornithine has been researched along with Brain Damage, Chronic in 2 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.

Research Excerpts

ExcerptRelevanceReference
"We have shown that transient cerebral ischemia gives rise to increased ODC mRNA and enzyme activity in the gerbil brain."1.29Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage. ( Dempsey, RJ; Hu, Y; Kindy, MS, 1994)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kindy, MS1
Hu, Y1
Dempsey, RJ1
de Vera, N1
Artigas, F1
Serratosa, J1
Martínez, E1

Other Studies

2 other studies available for eflornithine and Brain Damage, Chronic

ArticleYear
Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1994, Volume: 14, Issue:6

    Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cell Survival; Eflornithine; Gerbillinae; Male; Neur

1994
Changes in polyamine levels in rat brain after systemic kainic acid administration: relationship to convulsant activity and brain damage.
    Journal of neurochemistry, 1991, Volume: 57, Issue:1

    Topics: Animals; Body Weight; Brain; Brain Damage, Chronic; Eflornithine; Injections, Intraperitoneal; Kaini

1991