eflornithine has been researched along with Body Weight in 58 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia." | 7.67 | Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984) |
| "Potentially, non-melanoma skin cancer in humans may be prevented with these agents with few adverse effects." | 5.39 | Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. ( Burcharth, J; Pommergaard, HC; Raskov, H; Rosenberg, J, 2013) |
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal-bis-guanylhydrazone (MGBG), when administered simultaneously, inhibited growth and were highly toxic to the Dunning R 3327-G hormone-resistant prostatic adenocarcinoma transplanted into Copenhagen rats." | 3.67 | Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor. ( Herr, HW; Kleinert, EL, 1984) |
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia." | 3.67 | Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984) |
| "Because the cytotoxicity of most anti-cancer drugs can be attributed to inhibitory effects on DNA synthesis and cell replication it led to speculation that inhibition of polyamine synthesis could be a useful tool in the control of neoplastic growth." | 2.37 | The chemotherapeutic potential of polyamine antimetabolites. ( Kingsnorth, AN, 1986) |
| "Potentially, non-melanoma skin cancer in humans may be prevented with these agents with few adverse effects." | 1.39 | Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. ( Burcharth, J; Pommergaard, HC; Raskov, H; Rosenberg, J, 2013) |
| "The roles of polyamines in intrauterine growth restriction (IUGR) is studied." | 1.31 | Inhibition of placental ornithine decarboxylase by DL-alpha-difluoro-methyl ornithine causes fetal growth restriction in rat. ( Hiramatsu, Y; Ishida, M; Kudo, T; Masuyama, H; Mizutani, Y, 2002) |
| "The toxicity of DFMO in combination with TAM was evaluated in female Beagle dogs following 13 weeks of daily oral administration by capsule." | 1.30 | Thirteen-week oral toxicity study of difluoromethylornithine in combination with tamoxifen citrate in female dogs. ( Brown, AP; Crowell, JA; Levine, BS; Morrissey, RL, 1999) |
| " Chronic administration (52 weeks) by gavage to Charles River CD rats at dosages of 400, 800, and 1600 mg/kg produced weight loss, increased platelets, alopecia and skin abrasions, dermatitis, liver necrosis, and gastric inflammation." | 1.29 | Chronic toxicity studies of the potential cancer preventive 2-(difluoromethyl)-dl-ornithine. ( Boone, CW; Crowell, JA; Goldenthal, EI; Kelloff, GJ; Malone, WF, 1994) |
| "once weekly for 20 wk to induce colon cancer." | 1.28 | Reduced growth rate of dimethylhydrazine-induced colon tumors in rats. ( Koike, T; Shibusawa, M; Tsunoda, A; Tsunoda, Y; Yasuda, N, 1992) |
| " The effects of chronic administration of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase and thus polyamine biosynthesis, on vascular polyamine contents, structure, and function as well as the development of hypertension was studied." | 1.28 | Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension. ( Newman, PS; Olson, JW; Soltis, EE, 1991) |
| "Imipramine (IMI) was administered s." | 1.27 | Effect of prenatal imipramine exposure on development of the postnatal rat heart and brain. ( Delongchamp, RR; Harmon, JR; Kimmel, GL; Webb, PJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (50.00) | 18.7374 |
| 1990's | 22 (37.93) | 18.2507 |
| 2000's | 5 (8.62) | 29.6817 |
| 2010's | 2 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pommergaard, HC | 1 |
| Burcharth, J | 1 |
| Rosenberg, J | 1 |
| Raskov, H | 1 |
| Jasuja, R | 1 |
| Costello, JC | 1 |
| Singh, R | 1 |
| Gupta, V | 1 |
| Spina, CS | 1 |
| Toraldo, G | 1 |
| Jang, H | 1 |
| Li, H | 1 |
| Serra, C | 1 |
| Guo, W | 1 |
| Chauhan, P | 1 |
| Narula, NS | 1 |
| Guarneri, T | 1 |
| Ergun, A | 1 |
| Travison, TG | 1 |
| Collins, JJ | 1 |
| Bhasin, S | 1 |
| Rubin, MA | 1 |
| Wellmann, KA | 1 |
| Lewis, B | 1 |
| Overgaauw, BJ | 1 |
| Littleton, JM | 1 |
| Barron, S | 1 |
| Wang, X | 1 |
| Levic, S | 1 |
| Gratton, MA | 1 |
| Doyle, KJ | 1 |
| Yamoah, EN | 1 |
| Pegg, AE | 1 |
| Chen, X | 1 |
| Li, N | 1 |
| Wang, S | 1 |
| Hong, J | 1 |
| Fang, M | 1 |
| Yousselfson, J | 1 |
| Yang, P | 1 |
| Newman, RA | 1 |
| Lubet, RA | 1 |
| Yang, CS | 1 |
| Dunzendorfer, U | 1 |
| Relyea, NM | 2 |
| Kleinert, E | 1 |
| Balis, ME | 1 |
| Whitmore, WF | 3 |
| Prakash, NJ | 2 |
| Sunkara, PS | 1 |
| Luk, GD | 3 |
| Abeloff, MD | 2 |
| Griffin, CA | 1 |
| Baylin, SB | 2 |
| Herr, HW | 3 |
| Kleinert, EL | 3 |
| Conti, PS | 1 |
| Burchenal, JH | 1 |
| Kellen, JA | 1 |
| Chan, AW | 1 |
| Mirakian, A | 1 |
| Fozard, JR | 1 |
| Pedersen, SB | 1 |
| Bjørn, SF | 1 |
| Richelsen, B | 1 |
| Flyvbjerg, A | 1 |
| Crowell, JA | 3 |
| Goldenthal, EI | 1 |
| Kelloff, GJ | 1 |
| Malone, WF | 1 |
| Boone, CW | 1 |
| Younoszai, MK | 2 |
| Parekh, VV | 2 |
| Hoffman, JL | 2 |
| Thyssen, SM | 1 |
| Libertun, C | 1 |
| Stephen, TC | 1 |
| Sparapani, M | 1 |
| Virgili, M | 1 |
| Caprini, M | 1 |
| Facchinetti, F | 1 |
| Ciani, E | 1 |
| Contestabile, A | 1 |
| Brown, AP | 1 |
| Morrissey, RL | 1 |
| Levine, BS | 2 |
| Redgate, ES | 1 |
| Grudziak, AG | 1 |
| Deutsch, M | 1 |
| Boggs, SS | 1 |
| Kirchner, DL | 1 |
| Mercieca, MD | 1 |
| Friberg, P | 1 |
| Isgaard, J | 1 |
| Wåhlander, A | 1 |
| Wickman, A | 1 |
| Adams, MA | 1 |
| Lin, CH | 2 |
| Lyons, H | 1 |
| Seelbach, MS | 1 |
| Tolia, V | 1 |
| Vijesurier, R | 1 |
| Ishida, M | 1 |
| Hiramatsu, Y | 1 |
| Masuyama, H | 1 |
| Mizutani, Y | 1 |
| Kudo, T | 1 |
| Shrestha, RD | 2 |
| Fujimoto, S | 2 |
| Okui, K | 2 |
| Takeshita, S | 1 |
| Nagatomi, H | 1 |
| Ando, K | 1 |
| Evers, BM | 1 |
| Hurlbut, SC | 1 |
| Tyring, SK | 1 |
| Townsend, CM | 3 |
| Uchida, T | 1 |
| Thompson, JC | 3 |
| Lu, RB | 1 |
| Lebenthal, E | 2 |
| Lee, PC | 2 |
| Tsunoda, A | 1 |
| Shibusawa, M | 1 |
| Tsunoda, Y | 1 |
| Yasuda, N | 1 |
| Koike, T | 1 |
| Rao, CV | 1 |
| Tokumo, K | 2 |
| Rigotty, J | 2 |
| Zang, E | 2 |
| Kelloff, G | 2 |
| Reddy, BS | 2 |
| Soltis, EE | 1 |
| Newman, PS | 1 |
| Olson, JW | 2 |
| Gilad, GM | 1 |
| Gilad, VH | 1 |
| Gray, JA | 2 |
| Kavlock, RJ | 2 |
| de Vera, N | 1 |
| Artigas, F | 1 |
| Serratosa, J | 1 |
| Martínez, E | 1 |
| Nayini, J | 1 |
| Thomas, T | 1 |
| MacKenzie, SA | 1 |
| Gallo, MA | 1 |
| Bell, JM | 2 |
| Whitmore, WL | 1 |
| Slotkin, TA | 3 |
| Ferchmin, PA | 1 |
| Eterović, VA | 1 |
| Haarstad, H | 1 |
| Skei, T | 1 |
| Petersen, H | 1 |
| Rehnberg, BF | 1 |
| Rogers, EH | 1 |
| Lau, C | 1 |
| Orlinska, U | 1 |
| Gillespie, MN | 1 |
| Waldrop, RD | 1 |
| Saydjari, R | 1 |
| Rubin, NH | 1 |
| Rayford, PL | 1 |
| Kikuchi, K | 1 |
| Kikuchi, T | 1 |
| Miwa, T | 1 |
| Ghishan, FK | 1 |
| Harmon, JR | 1 |
| Webb, PJ | 1 |
| Kimmel, GL | 1 |
| Delongchamp, RR | 1 |
| Igarashi, K | 1 |
| Miyazaki, M | 1 |
| Endoh, F | 1 |
| Ohta, M | 1 |
| Togawa, Y | 1 |
| McCann, PP | 1 |
| Sjoerdsma, A | 1 |
| Kingsnorth, AN | 1 |
| Nigro, ND | 2 |
| Bull, AW | 2 |
| Boyd, ME | 2 |
| Smith, TK | 1 |
| Hyvönen, T | 1 |
| Pajula, RL | 1 |
| Eloranta, TO | 1 |
| Alarcon, P | 1 |
| Marx, M | 1 |
| Barranco, SC | 1 |
| Glass, EJ | 1 |
| Manni, A | 2 |
| Badger, B | 1 |
| Luk, G | 1 |
| Wright, C | 2 |
| Caplan, R | 1 |
| Rockette, H | 1 |
| Bartholomew, M | 1 |
| Ahmed, SR | 1 |
| Nishioka, K | 1 |
| Grossie, VB | 1 |
| Ajani, JA | 1 |
| Patenia, D | 1 |
| Chang, TH | 1 |
| Ota, DM | 1 |
| Pontari, M | 1 |
| Morisset, J | 1 |
| Benrezzak, O | 1 |
1 review available for eflornithine and Body Weight
| Article | Year |
|---|---|
The chemotherapeutic potential of polyamine antimetabolites.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Body Weight; Cell Division; Cell Line; Child; Drug | 1986 |
57 other studies available for eflornithine and Body Weight
| Article | Year |
|---|---|
Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Calcitriol; Chemoprevention; D | 2013 |
Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy.
Topics: Anabolic Agents; Animals; Body Weight; Eflornithine; Enzyme Inhibitors; Follistatin; Humans; Male; M | 2014 |
Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats.
Topics: Animals; Animals, Newborn; Body Weight; Central Nervous System Depressants; Eflornithine; Enzyme Inh | 2009 |
Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine.
Topics: Animals; Body Weight; Deafness; Eflornithine; Enzyme Inhibitors; Female; Male; Mice; Spermine Syntha | 2009 |
Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonic Acid; Body Weight; Cyclooxygenase 2 | 2002 |
Antigrowth effect of some inhibitors of polyamine synthesis on transplantable prostate cancer.
Topics: Animals; Body Weight; Drug Therapy, Combination; Eflornithine; Guanidines; Male; Mitoguazone; Neopla | 1983 |
Combination chemotherapy involving alpha-difluoromethylornithine and 1-beta-D-arabinofuranosylcytosine in murine L1210 leukemia.
Topics: Animals; Body Weight; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cytarabine; Drug Therapy, Combinat | 1983 |
Successful treatment with DL-alpha-difluoromethylornithine in established human small cell variant lung carcinoma implants in athymic mice.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Line; Drug Evaluation, Preclinical; Eflornithine; | 1983 |
Potentiation of methylglyoxal-bis-guanylhydrazone by alpha-difluoromethylornithine in rat prostate cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line; Dru | 1984 |
Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor.
Topics: Adenocarcinoma; Animals; Body Weight; Cell Division; Drug Therapy, Combination; Eflornithine; Guanid | 1984 |
Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Division; Drug Synergism; Eflornit | 1984 |
Effect of alpha-difluoromethyl ornithine on the transplantable rat hepatoma 5123, 1-1.
Topics: Animals; Antineoplastic Agents; Body Weight; Eflornithine; Liver Neoplasms, Experimental; Neoplasm T | 1980 |
Effects of DL-alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, on the rat mammary tumour induced by 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Body Weight; Carboxy-Lyases; Cyclo | 1982 |
Inhibition of renal ornithine decarboxylase activity fails to reduce kidney size and urinary albumin excretion in diabetic rats with manifest kidney hypertrophy.
Topics: Albuminuria; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diuresis; Eflorni | 1995 |
Chronic toxicity studies of the potential cancer preventive 2-(difluoromethyl)-dl-ornithine.
Topics: Animals; Anticarcinogenic Agents; Blood Cell Count; Blood Chemical Analysis; Body Weight; Cell Divis | 1994 |
Polyamines and intestinal epithelial hyperplasia in streptozotocin-diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Eflornithine; Epithelium; Hyperplasia; Intest | 1993 |
Alpha-difluoromethylornithine modifies FSH secretion and puberty onset in the female rat.
Topics: Animals; Body Weight; Eflornithine; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Ornithi | 1996 |
Relation of ornithine decarboxylase and tyrosine kinase activity in the jejunal mucosa in vivo.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; DNA; Drinking; Eating; Eflornithine; Electrop | 1996 |
Effects of gestational or neonatal treatment with alpha-difluoromethylornithine on ornithine decarboxylase and polyamines in developing rat brain and on adult rat neurochemistry.
Topics: Animals; Animals, Newborn; Body Weight; Brain Chemistry; Cerebellum; Choline O-Acetyltransferase; Ef | 1996 |
Thirteen-week oral toxicity study of difluoromethylornithine in combination with tamoxifen citrate in female dogs.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Body Weight; Dogs; Drug Synergism | 1999 |
Enhanced uptake of [3H] spermidine by 9L rat brain tumors after direct intratumoral infusion of inhibitors of enzymes of the polyamine biosynthetic pathway.
Topics: Adenosylmethionine Decarboxylase; Animals; Biological Transport; Body Weight; Brain Neoplasms; Corpu | 1999 |
Developmental toxicity studies of 2-(difluoromethyl)-dl-ornithine (DFMO) in rats and rabbits.
Topics: Animals; Body Weight; Bone and Bones; Cesarean Section; Dose-Response Relationship, Drug; Eflornithi | 1999 |
Inhibited expression of insulin-like growth factor I mRNA and attenuated cardiac hypertrophy in volume overloaded hearts treated with difluoromethylornithine.
Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Disease Models, Animal; Eflornithine; Gene Exp | 1998 |
Induction of gastric ornithine decarboxylase in early weaning rats.
Topics: Animals; Body Weight; Eflornithine; Enzyme Induction; Enzyme Inhibitors; Female; Gastric Mucosa; Mod | 2001 |
Inhibition of placental ornithine decarboxylase by DL-alpha-difluoro-methyl ornithine causes fetal growth restriction in rat.
Topics: Animals; Blood Proteins; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Eati | 2002 |
A novel anticancer treatment for xenoplanted human gastric cancer using polyamine antimetabolites in a low polyamine diet.
Topics: Adenosylmethionine Decarboxylase; Animals; Body Weight; Cell Division; Combined Modality Therapy; Di | 1992 |
Alleviation of intestinal lesions by combined treatment with a 5-fluoro-2'-deoxyuridine (FUDR) derivative and alpha-difluoromethylornithine (DFMO)[correction of DMFO] in tumor-bearing mice.
Topics: Amine Oxidase (Copper-Containing); Animals; Antineoplastic Combined Chemotherapy Protocols; Body Wei | 1992 |
Novel therapy for the treatment of human carcinoid.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinoid Tumor; Cell Line; Di | 1991 |
Essential role for polyamine biosynthesis in thyroxine stimulated pancreatic development in neonatal rats.
Topics: Amylases; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Chromatography, High Pressur | 1991 |
Reduced growth rate of dimethylhydrazine-induced colon tumors in rats.
Topics: Animals; Body Weight; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Eflornithine; Male; Mito | 1992 |
Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, alpha-difluoromethylornithine, 16 alpha-fluoro-5-androsten-17-one, and ellagic acid individually and in combination.
Topics: Animals; Body Weight; Colonic Neoplasms; Dehydroepiandrosterone; Drug Combinations; Drug Evaluation, | 1991 |
Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension.
Topics: Acetylcholine; Animals; Aorta; Arteries; Blood Pressure; Body Weight; Desoxycorticosterone; Dose-Res | 1991 |
Polyamines can protect against ischemia-induced nerve cell death in gerbil forebrain.
Topics: Analysis of Variance; Animals; Body Temperature; Body Weight; Brain; Eflornithine; Gerbillinae; Isch | 1991 |
Physiological consequences of early neonatal growth retardation: effects of alpha-difluoromethylornithine on renal growth and function in the rat.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Creatinine; Eflornithine; Femal | 1991 |
Changes in polyamine levels in rat brain after systemic kainic acid administration: relationship to convulsant activity and brain damage.
Topics: Animals; Body Weight; Brain; Brain Damage, Chronic; Eflornithine; Injections, Intraperitoneal; Kaini | 1991 |
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colonic Neopla | 1990 |
Regulation of polyamine biosynthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Topics: Animals; Ascites; Body Weight; Eflornithine; Female; Liver; Mice; Mice, Inbred Strains; Organ Size; | 1990 |
Effects of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: critical perinatal periods for regional selectivity.
Topics: Aging; Animals; Body Weight; Brain; DNA; Eflornithine; Female; Injections, Subcutaneous; Nerve Tissu | 1986 |
Role of polyamines in experience-dependent brain plasticity.
Topics: Animals; Body Weight; Brain; Cerebral Cortex; DNA; Eflornithine; Male; Neuronal Plasticity; Organ Si | 1987 |
Inhibition of polyamine synthesis by alpha-difluoromethylornithine and its effects on pancreatic secretion and growth in the rat.
Topics: Animals; Body Weight; Cholecystokinin; DNA; Eflornithine; Infusions, Intravenous; Male; Organ Size; | 1989 |
Prenatal alpha-difluoromethylornithine treatment: effects on postnatal renal growth and function in the rat.
Topics: Analysis of Variance; Animals; Body Weight; Creatinine; Eflornithine; Female; Gestational Age; Kidne | 1989 |
Polyamine synthesis blockade in monocrotaline-induced pneumotoxicity.
Topics: Animals; Biogenic Polyamines; Body Weight; Eflornithine; Heart; Hypertension, Pulmonary; Lung; Male; | 1989 |
Photoperiod influences the growth of colon cancer in mice.
Topics: Adenocarcinoma; Animals; Body Weight; Circadian Rhythm; Colonic Neoplasms; Eflornithine; Light; Male | 1989 |
Effect of dietary polyamines and alpha-difluoromethylornithine on regulation of intestinal Na+/H+ exchanger.
Topics: Animals; Body Weight; Diet; Eflornithine; Ileum; Intestinal Mucosa; Ion Exchange; Microvilli; Ornith | 1989 |
Effect of prenatal imipramine exposure on development of the postnatal rat heart and brain.
Topics: Aging; Animals; Body Weight; Brain; Dihydroalprenolol; Eflornithine; Female; Heart; Imipramine; Litt | 1986 |
Combined therapy of polyamine antimetabolites and antitumor drugs for human gastric cancer xenotransplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcino | 1986 |
Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine.
Topics: Animals; Body Weight; Carcinoma, Small Cell; Cell Aggregation; Eflornithine; Female; Lung Neoplasms; | 1986 |
Polyamines as intermediates in developmental neurotoxic events.
Topics: Animals; Body Weight; Brain; Cell Division; DNA Replication; Eflornithine; Female; Organ Size; Ornit | 1986 |
Inhibition of intestinal carcinogenesis in rats: effect of difluoromethylornithine with piroxicam or fish oil.
Topics: Animals; Body Weight; Diet; Drinking; Eating; Eflornithine; Fish Oils; Intestinal Neoplasms; Male; P | 1986 |
Importance of the duration of inhibition on intestinal carcinogenesis by difluoromethylornithine in rats.
Topics: Animals; Azo Compounds; Azoxymethane; Body Weight; Drinking; Eating; Eflornithine; Intestinal Neopla | 1987 |
Effect of dietary methionine, arginine and ornithine on the metabolism and accumulation of polyamines, S-adenosylmethionine and macromolecules in rat liver and skeletal muscle.
Topics: Amino Acids; Animals; Arginine; Body Weight; Diet; Eflornithine; Liver; Macromolecular Substances; M | 1987 |
Effect of difluoromethyl ornithine (DFMO) on small intestine of adult and weanling rats.
Topics: Age Factors; Animals; Animals, Suckling; Body Weight; Eflornithine; Enzymes; Food; Intestinal Mucosa | 1987 |
Treatment of hamster pancreatic cancer with alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis.
Topics: Adenocarcinoma; Animals; Body Weight; Cricetinae; Depression, Chemical; Eflornithine; Male; Mesocric | 1987 |
Role of polyamines in the growth of hormone-responsive experimental breast cancer in vivo.
Topics: Animals; Biogenic Polyamines; Body Weight; Dose-Response Relationship, Drug; Eflornithine; Female; M | 1988 |
Polyamine-directed preferential nutritional repletion of normal tissues in tumor-bearing hosts.
Topics: Animals; Body Weight; Eflornithine; Erythrocytes; Fibrosarcoma; Methylcholanthrene; Nutrition Disord | 1988 |
Polyamines and estrogen control of growth of the NMU-induced rat mammary tumor.
Topics: Animals; Body Weight; Cell Division; Dose-Response Relationship, Drug; Drug Interactions; Eflornithi | 1985 |
Reversal of alpha-difluoromethylornithine inhibition of caerulein-induced pancreatic growth by putrescine.
Topics: Animals; Body Weight; Ceruletide; DNA; DNA Replication; Eflornithine; Male; Organ Size; Ornithine; O | 1985 |