eflornithine has been researched along with Blood Pressure, High in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These studies indicate that normalization of vascular function can occur in the presence of significantly elevated blood pressure upon chronic administration of eflornithine." | 5.30 | Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. ( Aziz, SM; Lipke, DW; Newman, PS; Soltis, EE; Tofiq, S, 1997) |
| " The effects of chronic administration of eflornithine (alpha-difluoromethylornithine; DFMO), a highly specific inhibitor of ornithine decarboxylase (the rate limiting enzyme in polyamine biosynthesis), on vascular polyamine contents, vascular structure and function, and blood pressure was studied." | 5.29 | Eflornithine treatment in SHR: potential role of vascular polyamines and ornithine decarboxylase in hypertension. ( Newman, PS; Olson, JW; Soltis, EE, 1994) |
| " This study examined the effects of polyamine synthesis inhibition using eflornithine, a suicide inhibitor of ornithine decarboxylase on blood pressure, compensatory remodeling of the cardiovascular system, and cardiac and aortic polyamine contents using an aortic coarctation model in rats." | 3.69 | Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension. ( Arcot, SS; Aziz, SM; Guo, H; Lipke, DW; Newman, PS; Olson, JW; Soltis, EE; Tofiq, S, 1997) |
| "A decrease in nitric oxide (NO) bioavailability has been proposed to contribute to endothelial dysfunction and increased peripheral resistances during essential arterial hypertension." | 1.33 | Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats. ( Berthelot, A; Demougeot, C; Marie, C; Prigent-Tessier, A, 2005) |
| " These studies indicate that normalization of vascular function can occur in the presence of significantly elevated blood pressure upon chronic administration of eflornithine." | 1.30 | Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. ( Aziz, SM; Lipke, DW; Newman, PS; Soltis, EE; Tofiq, S, 1997) |
| " The effects of chronic administration of eflornithine (alpha-difluoromethylornithine; DFMO), a highly specific inhibitor of ornithine decarboxylase (the rate limiting enzyme in polyamine biosynthesis), on vascular polyamine contents, vascular structure and function, and blood pressure was studied." | 1.29 | Eflornithine treatment in SHR: potential role of vascular polyamines and ornithine decarboxylase in hypertension. ( Newman, PS; Olson, JW; Soltis, EE, 1994) |
| " The effects of chronic administration of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase and thus polyamine biosynthesis, on vascular polyamine contents, structure, and function as well as the development of hypertension was studied." | 1.28 | Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension. ( Newman, PS; Olson, JW; Soltis, EE, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Demougeot, C | 1 |
| Prigent-Tessier, A | 1 |
| Marie, C | 1 |
| Berthelot, A | 1 |
| Soltis, EE | 4 |
| Newman, PS | 4 |
| Olson, JW | 3 |
| Lipke, DW | 2 |
| Tofiq, S | 2 |
| Guo, H | 1 |
| Arcot, SS | 1 |
| Aziz, SM | 2 |
5 other studies available for eflornithine and Blood Pressure, High
| Article | Year |
|---|---|
Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats.
Topics: Animals; Aorta; Arginase; Blood Pressure; Eflornithine; Endothelium, Vascular; Enzyme Inhibitors; Hy | 2005 |
Eflornithine treatment in SHR: potential role of vascular polyamines and ornithine decarboxylase in hypertension.
Topics: Animals; Biogenic Polyamines; Blood Pressure; Blood Vessels; Eflornithine; Electric Stimulation; Hyp | 1994 |
Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension.
Topics: Animals; Aorta, Abdominal; Aortic Coarctation; Blood Pressure; Blotting, Northern; Eflornithine; Enz | 1997 |
Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension.
Topics: Acetylcholine; Animals; Aorta; Aortic Coarctation; Eflornithine; Enzyme Inhibitors; Hypertension; Mu | 1997 |
Polyamines, vascular smooth muscle, and deoxycorticosterone acetate-salt hypertension.
Topics: Acetylcholine; Animals; Aorta; Arteries; Blood Pressure; Body Weight; Desoxycorticosterone; Dose-Res | 1991 |