eflornithine has been researched along with Blood Diseases in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This open trial shows that DFMO is as active as and possibly less toxic than melarsoprol." | 2.67 | Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness. ( Ethier, L; Loko, L; Milord, F; Mpia, B; Pépin, J, 1992) |
| "Recent clinical cancer chemoprevention trials, using dose de-escalation designs, indicate that DFMO can be given over long periods of time at low doses that suppress polyamine contents in gastrointestinal and other epithelial tissues but cause no detectable hearing loss or other side effects." | 2.40 | Development of difluoromethylornithine (DFMO) as a chemoprevention agent. ( Gerner, EW; Meyskens, FL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bespalov, VG | 1 |
| Aleksandrov, VA | 1 |
| Semenov, AL | 1 |
| Kovan'ko, EG | 1 |
| Ivanov, SD | 1 |
| Meyskens, FL | 1 |
| Gerner, EW | 1 |
| Milord, F | 1 |
| Pépin, J | 1 |
| Loko, L | 1 |
| Ethier, L | 1 |
| Mpia, B | 1 |
| Abeloff, MD | 1 |
| Rosen, ST | 1 |
| Luk, GD | 1 |
| Baylin, SB | 1 |
| Zeltzman, M | 1 |
| Sjoerdsma, A | 1 |
1 review available for eflornithine and Blood Diseases
| Article | Year |
|---|---|
Development of difluoromethylornithine (DFMO) as a chemoprevention agent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Cell Division; Cell Trans | 1999 |
1 trial available for eflornithine and Blood Diseases
| Article | Year |
|---|---|
Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness.
Topics: Administration, Oral; Animals; Cerebrospinal Fluid; Democratic Republic of the Congo; Diarrhea; Eflo | 1992 |
2 other studies available for eflornithine and Blood Diseases
| Article | Year |
|---|---|
[Comparative effects of difluoromethylornithine and tincture of Siberian ginseng root on radiation carcinogenesis and life span in rats].
Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Eflornithine; Eleutherococcus; Fema | 2012 |
Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer.
Topics: Aged; Antineoplastic Agents; Carcinoma, Small Cell; Colonic Neoplasms; Drug Evaluation; Eflornithine | 1986 |