eflornithine has been researched along with Barrett Esophagus in 8 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Barrett Esophagus: A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with Barrett's esophagus (BE) and dysplasia are candidates for chemopreventive strategies to reduce cancer risk." | 1.37 | Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia. ( Broaddus, R; Gerner, E; Half, E; Hong, WK; Joshi, N; Kirsch, I; Lewin, J; Morlan, B; Sinicrope, FA, 2011) |
| "Reversible hearing loss is a recognized toxicity of DFMO that usually occurs at doses above 2 g/m(2)/d, and generally when the cumulative dose exceeds 250 g/m(2)." | 1.32 | Irreversible ototoxicity associated with difluoromethylornithine. ( Backoff, P; Brenner, DE; Eaton, T; Hawk, ET; Lao, CD; McCarty, D; Ondrey, FG; Shotland, LI; Spechler, SJ; Viner, JL, 2004) |
| "Eight patients with Barrett's esophagus were treated with DFMO at a dose of 1." | 1.29 | Gastrointestinal tissue polyamine contents of patients with Barrett's esophagus treated with alpha-difluoromethylornithine. ( Emerson, SS; Garewal, HS; Gerner, EW; Sampliner, RE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akiyama, J | 1 |
| Alexandre, L | 1 |
| Baruah, A | 1 |
| Buttar, N | 1 |
| Chandra, R | 1 |
| Clark, AB | 1 |
| Hart, AR | 1 |
| Hawk, E | 1 |
| Kandioler, D | 1 |
| Kappel, S | 1 |
| Krishnadath, SK | 1 |
| Sharma, A | 1 |
| Singh, I | 1 |
| Straub, D | 1 |
| Triadafilopoulos, G | 1 |
| Umar, A | 1 |
| Wolf, B | 1 |
| Yachimski, P | 1 |
| Peek, RM | 1 |
| Sinicrope, FA | 1 |
| Broaddus, R | 1 |
| Joshi, N | 1 |
| Gerner, E | 1 |
| Half, E | 1 |
| Kirsch, I | 1 |
| Lewin, J | 1 |
| Morlan, B | 1 |
| Hong, WK | 1 |
| Souza, RF | 1 |
| Spechler, SJ | 2 |
| Lao, CD | 1 |
| Backoff, P | 1 |
| Shotland, LI | 1 |
| McCarty, D | 1 |
| Eaton, T | 1 |
| Ondrey, FG | 1 |
| Viner, JL | 1 |
| Hawk, ET | 1 |
| Brenner, DE | 1 |
| Gerner, EW | 2 |
| Garewal, HS | 3 |
| Emerson, SS | 1 |
| Sampliner, RE | 2 |
| Roe, D | 1 |
2 reviews available for eflornithine and Barrett Esophagus
| Article | Year |
|---|---|
Barrett's esophagus: chemoprevention.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Barrett Esophagus; Cyclooxygenase Inhibi | 2003 |
Chemoprevention of Barrett's esophagus and oral leukoplakia.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Barrett Esophagus; Biomarkers; Carcinoma, Squamous Cell; Ca | 1992 |
1 trial available for eflornithine and Barrett Esophagus
| Article | Year |
|---|---|
Chemoprevention of Barrett's esophagus and oral leukoplakia.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Barrett Esophagus; Biomarkers; Carcinoma, Squamous Cell; Ca | 1992 |
6 other studies available for eflornithine and Barrett Esophagus
| Article | Year |
|---|---|
Strategy for prevention of cancers of the esophagus.
Topics: Animals; Antineoplastic Agents; Barrett Esophagus; Biomarkers, Tumor; Cell Transformation, Neoplasti | 2014 |
Biomarkers in exploring the frontiers of diagnosis, prognosis, and therapy of Barrett's esophagus.
Topics: Antineoplastic Agents; Barrett Esophagus; Biomarkers, Tumor; Eflornithine; Female; Humans; Male; Muc | 2011 |
Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia.
Topics: Aged; Antineoplastic Agents; Barrett Esophagus; Eflornithine; Female; Humans; Male; Middle Aged; Muc | 2011 |
Irreversible ototoxicity associated with difluoromethylornithine.
Topics: Antineoplastic Agents; Barrett Esophagus; Cell Proliferation; Chemoprevention; Eflornithine; Hearing | 2004 |
Gastrointestinal tissue polyamine contents of patients with Barrett's esophagus treated with alpha-difluoromethylornithine.
Topics: Aged; Analysis of Variance; Barrett Esophagus; Biopsy; Confidence Intervals; Digestive System; Eflor | 1994 |
Ornithine decarboxylase and polyamine levels in columnar upper gastrointestinal mucosae in patients with Barrett's esophagus.
Topics: Barrett Esophagus; Cell Division; Eflornithine; Epithelial Cells; Epithelium; Esophageal Diseases; G | 1988 |