eflornithine has been researched along with B16 Melanoma in 13 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The uptake of intracellular putrescine and spermidine was examined in B16 melanoma cells." | 7.68 | Evidence for the existence of distinct transporters for the polyamines putrescine and spermidine in B16 melanoma cells. ( Ilett, KF; Martin, RL; Minchin, RF; Raso, A, 1991) |
| "Several bipyridinium, tetrapyridinium and hexapyridinium quaternary salts have been found to be potent inhibitors of putrescine uptake into B16 melanoma cells which had previously been treated with difluoromethylornithine." | 7.67 | Inhibition of putrescine uptake by polypyridinium quaternary salts in B16 melanoma cells treated with difluoromethylornithine. ( Ilett, KF; Martin, RL; Minchin, RF; Summers, LA, 1989) |
| "The uptake of intracellular putrescine and spermidine was examined in B16 melanoma cells." | 3.68 | Evidence for the existence of distinct transporters for the polyamines putrescine and spermidine in B16 melanoma cells. ( Ilett, KF; Martin, RL; Minchin, RF; Raso, A, 1991) |
| "We have examined the effect of difluoromethylornithine on the ability of B16 melanoma cells to take up putrescine and the 4,4'-dipyridyl herbicide paraquat." | 3.67 | Paraquat is not accumulated in B16 tumor cells by the polyamine transport system. ( Ilett, KF; Martin, RL; Minchin, RF, 1989) |
| "Several bipyridinium, tetrapyridinium and hexapyridinium quaternary salts have been found to be potent inhibitors of putrescine uptake into B16 melanoma cells which had previously been treated with difluoromethylornithine." | 3.67 | Inhibition of putrescine uptake by polypyridinium quaternary salts in B16 melanoma cells treated with difluoromethylornithine. ( Ilett, KF; Martin, RL; Minchin, RF; Summers, LA, 1989) |
| "Melanoma is a disease that need not be deadly." | 2.38 | The prevention of cutaneous malignant melanoma: high-risk groups, chemoprevention, education, and screening. ( Greene, MH, 1993) |
| "DFMO inhibited the proliferation of B16 melanoma cells in culture but the inhibitory effect was much less than that on BPAE cells." | 1.28 | Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. ( Enomoto, M; Kinoshita, A; Nishida, Y; Pan, HO; Suzuki, F; Takigawa, M, 1990) |
| "Using B16 melanoma cells, we have shown that these two drugs inhibit growth over 72 hr in vitro." | 1.28 | Difluoromethylornithine prevents the down-regulation of type I interferon receptors: a possible mechanism for a synergistic antiproliferative effect. ( Beilharz, MW; Dilollo, DL; Lai, MC; Minchin, RF, 1990) |
| "Treatment of mice bearing B16 melanoma with DFMO resulted in 81% inhibition of tumor growth compared to controls." | 1.28 | Effect of murine alpha-, beta-, and gamma-interferons in combination with alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, on the tumor growth and metastasis of B16 melanoma and Lewis lung carcinoma in mice. ( Bowlin, TL; Fleischmann, WR; Rosenberger, AL; Sunkara, PS, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 8 (61.54) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stark, PA | 1 |
| Thrall, BD | 1 |
| Meadows, GG | 1 |
| Abdel-Monem, MM | 1 |
| Greene, MH | 1 |
| Süli-Vargha, H | 1 |
| Morandini, R | 1 |
| Bódi, J | 1 |
| Nagy, L | 1 |
| Medzihradszky-Schweiger, H | 1 |
| Ghanem, G | 1 |
| Sanchez Mas, J | 1 |
| Martijnez-Esparza, M | 1 |
| Bastida, CM | 1 |
| Solano, F | 1 |
| Penafiel, R | 1 |
| Garcija-Borron, JC | 1 |
| Sanborn, G | 1 |
| Niederkorn, J | 1 |
| Kan-Mitchell, J | 1 |
| Albert, D | 1 |
| Takigawa, M | 1 |
| Enomoto, M | 1 |
| Nishida, Y | 1 |
| Pan, HO | 1 |
| Kinoshita, A | 1 |
| Suzuki, F | 1 |
| Minchin, RF | 4 |
| Raso, A | 1 |
| Martin, RL | 3 |
| Ilett, KF | 3 |
| Bowlin, TL | 3 |
| Hoeper, BJ | 1 |
| Rosenberger, AL | 2 |
| Davis, GF | 2 |
| Sunkara, PS | 3 |
| Dilollo, DL | 1 |
| Beilharz, MW | 1 |
| Lai, MC | 1 |
| Fleischmann, WR | 1 |
| Summers, LA | 1 |
| McKown, BJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for eflornithine and B16 Melanoma
| Article | Year |
|---|---|
The prevention of cutaneous malignant melanoma: high-risk groups, chemoprevention, education, and screening.
Topics: Animals; Anticarcinogenic Agents; Dysplastic Nevus Syndrome; Eflornithine; Fluorouracil; Humans; Mas | 1993 |
12 other studies available for eflornithine and B16 Melanoma
| Article | Year |
|---|---|
Synthesis and evaluation of novel spermidine derivatives as targeted cancer chemotherapeutic agents.
Topics: Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; Melanoma, Experimental; | 1992 |
In vitro cytotoxic effect of difluoromethylomithine increased nonspecifically by peptide coupling.
Topics: Antineoplastic Agents; Eflornithine; Humans; Hydrolysis; Melanocyte-Stimulating Hormones; Melanoma, | 1997 |
Regulation of ornithine decarboxylase in B16 mouse melanoma cells: synergistic activation of melanogenesis by alphaMSH and ornithine decarboxylase inhibition.
Topics: alpha-MSH; Animals; Cell Line; Eflornithine; Enzyme Activation; Gene Expression Regulation, Enzymolo | 2002 |
Prevention of metastasis of intraocular melanoma in mice treated with difluoromethylornithine.
Topics: Administration, Oral; Animals; Anterior Eye Segment; Cell Division; Disease Models, Animal; DNA, Neo | 1992 |
Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro.
Topics: Animals; Cattle; Cell Division; Chick Embryo; DNA, Neoplasm; Eflornithine; Endothelium, Vascular; Me | 1990 |
Evidence for the existence of distinct transporters for the polyamines putrescine and spermidine in B16 melanoma cells.
Topics: Affinity Labels; Biological Transport; Carrier Proteins; Eflornithine; Kinetics; Melanoma, Experimen | 1991 |
Effects of three irreversible inhibitors of ornithine decarboxylase on macrophage-mediated tumoricidal activity and antitumor activity in B16F1 tumor-bearing mice.
Topics: Alkynes; Animals; Antineoplastic Agents; Cell Line; Cytotoxicity, Immunologic; Diamines; Eflornithin | 1990 |
Difluoromethylornithine prevents the down-regulation of type I interferon receptors: a possible mechanism for a synergistic antiproliferative effect.
Topics: Animals; Cell Division; Down-Regulation; Drug Synergism; Eflornithine; Interferon Type I; Melanoma, | 1990 |
Effect of murine alpha-, beta-, and gamma-interferons in combination with alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, on the tumor growth and metastasis of B16 melanoma and Lewis lung carcinoma in mice.
Topics: Animals; Drug Synergism; Eflornithine; Interferon Type I; Interferon-gamma; Lung Neoplasms; Melanoma | 1989 |
Paraquat is not accumulated in B16 tumor cells by the polyamine transport system.
Topics: Biological Transport; Dose-Response Relationship, Drug; Eflornithine; Kinetics; Melanoma, Experiment | 1989 |
Inhibition of putrescine uptake by polypyridinium quaternary salts in B16 melanoma cells treated with difluoromethylornithine.
Topics: Animals; Eflornithine; Melanoma, Experimental; Mice; Putrescine; Pyridinium Compounds; Tumor Cells, | 1989 |
Effect of polyamine depletion in vivo by DL-alpha-difluoromethylornithine on functionally distinct populations of tumoricidal effector cells in normal and tumor-bearing mice.
Topics: Animals; Eflornithine; Immunity, Cellular; Killer Cells, Natural; Lymphocyte Activation; Macrophages | 1986 |