eflornithine has been researched along with Autoimmune Diabetes in 4 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The underlying pathophysiology of type 1 diabetes involves autoimmune-mediated islet inflammation, leading to dysfunction and death of insulin-secreting islet β cells." | 1.40 | Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy. ( Colvin, SC; Maier, B; Mirmira, RG; Tersey, SA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sims, EK | 1 |
| Kulkarni, A | 1 |
| Hull, A | 1 |
| Woerner, SE | 1 |
| Cabrera, S | 1 |
| Mastrandrea, LD | 1 |
| Hammoud, B | 1 |
| Sarkar, S | 1 |
| Nakayasu, ES | 1 |
| Mastracci, TL | 1 |
| Perkins, SM | 1 |
| Ouyang, F | 1 |
| Webb-Robertson, BJ | 1 |
| Enriquez, JR | 1 |
| Tersey, SA | 2 |
| Evans-Molina, C | 1 |
| Long, SA | 1 |
| Blanchfield, L | 1 |
| Gerner, EW | 1 |
| Mirmira, RG | 2 |
| DiMeglio, LA | 1 |
| Colvin, SC | 1 |
| Maier, B | 1 |
| Satriano, J | 1 |
| Parekh, VV | 1 |
| Hoffman, JL | 1 |
| Younoszai, MK | 1 |
1 review available for eflornithine and Autoimmune Diabetes
| Article | Year |
|---|---|
Kidney growth, hypertrophy and the unifying mechanism of diabetic complications.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Cycle Proteins; Cyclin-Depende | 2007 |
1 trial available for eflornithine and Autoimmune Diabetes
| Article | Year |
|---|---|
Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Type 1; Eflornithine; Humans; Mice; Ornithine Decarboxylase; Ornithine D | 2023 |
2 other studies available for eflornithine and Autoimmune Diabetes
| Article | Year |
|---|---|
Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Re | 2014 |
Role of tyrosine kinase, ODC, and p34cdc2 kinase and cyclin B-associated cdc2 in jejunal enterocyte proliferation, maturation, and exfoliation in diabetic and DFMO-treated rats.
Topics: Animals; Biomarkers; CDC2 Protein Kinase; Cell Division; Cyclin B; Cyclin-Dependent Kinase-Activatin | 1999 |