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eflornithine and Atypical Ductal Hyperplasia

eflornithine has been researched along with Atypical Ductal Hyperplasia in 3 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
" ODC gene dosage was analyzed by Southern blot hybridization and was 4- to 12-fold higher in T-47D, MDA-MB-231, and BT-20 cell lines than in the MCF-7 cell line."1.28Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells. ( Jänne, OA; Kiang, DT; Thomas, T; Thomas, TJ, 1991)
"CsA had inhibitory effects on H2T pancreatic cancer growth similar to those of alpha-DFMO; these effects were blocked by the addition of the polyamine putrescine."1.27Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro. ( Barranco, SC; James, E; Saydjari, R; Thompson, JC; Townsend, CM, 1986)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Izbicka, E1
Streeper, RT1
Yeh, IT1
Pressley, O1
Grant, M1
Andrews, JV1
Kuhn, J1
O'Shaughnessy, J1
Thomas, T1
Kiang, DT1
Jänne, OA1
Thomas, TJ1
Saydjari, R1
Townsend, CM1
Barranco, SC1
James, E1
Thompson, JC1

Other Studies

3 other studies available for eflornithine and Atypical Ductal Hyperplasia

ArticleYear
Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer.
    Anticancer research, 2010, Volume: 30, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Intraductal, Nonin

2010
Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells.
    Breast cancer research and treatment, 1991, Volume: 19, Issue:3

    Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm;

1991
Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro.
    Journal of the National Cancer Institute, 1986, Volume: 77, Issue:5

    Topics: Animals; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Line; Cell Survival; Cricetinae;

1986