eflornithine has been researched along with Atypical Ductal Hyperplasia in 3 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " ODC gene dosage was analyzed by Southern blot hybridization and was 4- to 12-fold higher in T-47D, MDA-MB-231, and BT-20 cell lines than in the MCF-7 cell line." | 1.28 | Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells. ( Jänne, OA; Kiang, DT; Thomas, T; Thomas, TJ, 1991) |
| "CsA had inhibitory effects on H2T pancreatic cancer growth similar to those of alpha-DFMO; these effects were blocked by the addition of the polyamine putrescine." | 1.27 | Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro. ( Barranco, SC; James, E; Saydjari, R; Thompson, JC; Townsend, CM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Izbicka, E | 1 |
| Streeper, RT | 1 |
| Yeh, IT | 1 |
| Pressley, O | 1 |
| Grant, M | 1 |
| Andrews, JV | 1 |
| Kuhn, J | 1 |
| O'Shaughnessy, J | 1 |
| Thomas, T | 1 |
| Kiang, DT | 1 |
| Jänne, OA | 1 |
| Thomas, TJ | 1 |
| Saydjari, R | 1 |
| Townsend, CM | 1 |
| Barranco, SC | 1 |
| James, E | 1 |
| Thompson, JC | 1 |
3 other studies available for eflornithine and Atypical Ductal Hyperplasia
| Article | Year |
|---|---|
Effects of alpha-difluoromethylornithine on markers of proliferation, invasion, and apoptosis in breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Intraductal, Nonin | 2010 |
Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm; | 1991 |
Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro.
Topics: Animals; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Line; Cell Survival; Cricetinae; | 1986 |