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eflornithine and Ascites

eflornithine has been researched along with Ascites in 3 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Ascites: Accumulation or retention of free fluid within the peritoneal cavity.

Research Excerpts

ExcerptRelevanceReference
"Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine."7.70Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998)
"Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine."3.70Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ashida, Y2
Ueno, A1
Miwa, Y1
Miyoshi, K1
Inoue, H2
Kido, J1
Kinoshita, F1
Nishino, M1
Shinkai, K1
Akedo, H1
Thomas, T1
MacKenzie, SA1
Gallo, MA1

Other Studies

3 other studies available for eflornithine and Ascites

ArticleYear
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
    Japanese journal of cancer research : Gann, 1998, Volume: 89, Issue:1

    Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell

1998
Putrescine-dependent invasive capacity of rat ascites hepatoma cells.
    Cancer research, 1992, Oct-01, Volume: 52, Issue:19

    Topics: Animals; Ascites; Biogenic Polyamines; Cattle; Cells, Cultured; Eflornithine; Endothelium, Vascular;

1992
Regulation of polyamine biosynthesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
    Toxicology letters, 1990, Volume: 53, Issue:3

    Topics: Animals; Ascites; Body Weight; Eflornithine; Female; Liver; Mice; Mice, Inbred Strains; Organ Size;

1990