eflornithine has been researched along with Aortic Coarctation in 2 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Aortic Coarctation: A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These studies indicate that normalization of vascular function can occur in the presence of significantly elevated blood pressure upon chronic administration of eflornithine." | 5.30 | Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. ( Aziz, SM; Lipke, DW; Newman, PS; Soltis, EE; Tofiq, S, 1997) |
| " This study examined the effects of polyamine synthesis inhibition using eflornithine, a suicide inhibitor of ornithine decarboxylase on blood pressure, compensatory remodeling of the cardiovascular system, and cardiac and aortic polyamine contents using an aortic coarctation model in rats." | 3.69 | Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension. ( Arcot, SS; Aziz, SM; Guo, H; Lipke, DW; Newman, PS; Olson, JW; Soltis, EE; Tofiq, S, 1997) |
| " These studies indicate that normalization of vascular function can occur in the presence of significantly elevated blood pressure upon chronic administration of eflornithine." | 1.30 | Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. ( Aziz, SM; Lipke, DW; Newman, PS; Soltis, EE; Tofiq, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lipke, DW | 2 |
| Newman, PS | 2 |
| Tofiq, S | 2 |
| Guo, H | 1 |
| Arcot, SS | 1 |
| Aziz, SM | 2 |
| Olson, JW | 1 |
| Soltis, EE | 2 |
2 other studies available for eflornithine and Aortic Coarctation
| Article | Year |
|---|---|
Multiple polyamine regulatory pathways control compensatory cardiovascular hypertrophy in coarctation hypertension.
Topics: Animals; Aorta, Abdominal; Aortic Coarctation; Blood Pressure; Blotting, Northern; Eflornithine; Enz | 1997 |
Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension.
Topics: Acetylcholine; Animals; Aorta; Aortic Coarctation; Eflornithine; Enzyme Inhibitors; Hypertension; Mu | 1997 |