Page last updated: 2024-10-25

eflornithine and Angiogenesis, Pathologic

eflornithine has been researched along with Angiogenesis, Pathologic in 5 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"DFMO inhibited the proliferation of B16 melanoma cells in culture but the inhibitory effect was much less than that on BPAE cells."1.28Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. ( Enomoto, M; Kinoshita, A; Nishida, Y; Pan, HO; Suzuki, F; Takigawa, M, 1990)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Konturek, SJ1
Brzozowski, T1
Majka, I1
Pawlik, W1
Stachura, J1
Jasnis, MA1
Klein, S1
Monte, M1
Davel, L1
Sacerdote de Lustig, E1
Algranati, ID1
Takahashi, Y1
Mai, M1
Nishioka, K1
Lan, L1
Trempus, C1
Gilmour, SK1
Takigawa, M1
Enomoto, M1
Nishida, Y1
Pan, HO1
Kinoshita, A1
Suzuki, F1

Other Studies

5 other studies available for eflornithine and Angiogenesis, Pathologic

ArticleYear
Omentum and basic fibroblast growth factor in healing of chronic gastric ulcerations in rats.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:5

    Topics: Animals; Blood Flow Velocity; Chronic Disease; Dinoprostone; Eflornithine; Fibroblast Growth Factor

1994
Polyamines prevent DFMO-mediated inhibition of angiogenesis.
    Cancer letters, 1994, Apr-29, Volume: 79, Issue:1

    Topics: Adenocarcinoma; Analysis of Variance; Animals; Eflornithine; Female; Lymphocytes; Mammary Neoplasms,

1994
alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model.
    International journal of cancer, 2000, Jan-15, Volume: 85, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Disease Models, Animal; Eflornithine; Endo

2000
Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice.
    Cancer research, 2000, Oct-15, Volume: 60, Issue:20

    Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Crosses, Genetic; Eflornithine;

2000
Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro.
    Cancer research, 1990, Jul-01, Volume: 50, Issue:13

    Topics: Animals; Cattle; Cell Division; Chick Embryo; DNA, Neoplasm; Eflornithine; Endothelium, Vascular; Me

1990