eflornithine has been researched along with Alopecia in 7 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Alopecia: Absence of hair from areas where it is normally present.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Moreover, assessment of biochemical hyperandrogenism is necessary, particularly in patients with unclear or absent hirsutism, and will include assessing total and free testosterone (T), and possibly dehydroepiandrosterone sulfate (DHEAS) and androstenedione, although these latter contribute limitedly to the diagnosis." | 4.93 | Androgen excess: Investigations and management. ( Azziz, R; Gavrilova-Jordan, L; Lizneva, D; Walker, W, 2016) |
| "However, DFMO treatment led to marked hair loss in PKC epsilon transgenic mice." | 1.32 | Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. ( Ness, KJ; Oberley, TD; Verma, AK; Wheeler, DL, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| VanSickle, EA | 2 |
| Michael, J | 1 |
| Bachmann, AS | 3 |
| Rajasekaran, S | 3 |
| Prokop, JW | 2 |
| Kuzniecky, R | 1 |
| Hofstede, FC | 1 |
| Steindl, K | 1 |
| Rauch, A | 1 |
| Lipson, MH | 1 |
| Bupp, CP | 3 |
| Leimanis-Laurens, M | 1 |
| Shukla, A | 1 |
| Russell, C | 1 |
| Junewick, J | 1 |
| Gleason, E | 1 |
| Edgerly, Y | 1 |
| Wittmann, BM | 1 |
| Hermosura Almazan, T | 1 |
| Kabigting, FD | 1 |
| Schultz, CR | 1 |
| Lizneva, D | 1 |
| Gavrilova-Jordan, L | 1 |
| Walker, W | 1 |
| Azziz, R | 1 |
| Mason, H | 1 |
| Colao, A | 1 |
| Blume-Peytavi, U | 1 |
| Rice, S | 1 |
| Qureshi, A | 1 |
| Pellatt, L | 1 |
| Orio, F | 1 |
| Atkin, SL | 1 |
| Wheeler, DL | 1 |
| Ness, KJ | 1 |
| Oberley, TD | 1 |
| Verma, AK | 1 |
3 reviews available for eflornithine and Alopecia
| Article | Year |
|---|---|
Dermatologic care of the transgender patient.
Topics: Acne Vulgaris; Alopecia; Androgen Antagonists; Androgens; Cicatrix; Dermal Fillers; Dermatology; Efl | 2016 |
Androgen excess: Investigations and management.
Topics: 5-alpha Reductase Inhibitors; Acne Vulgaris; Alopecia; Androgen Antagonists; Androstenedione; Contra | 2016 |
Polycystic ovary syndrome (PCOS) trilogy: a translational and clinical review.
Topics: Acne Vulgaris; Alopecia; Anovulation; Cardiovascular Diseases; Eflornithine; Female; Hirsutism; Huma | 2008 |
4 other studies available for eflornithine and Alopecia
| Article | Year |
|---|---|
Expanding the phenotype: Four new cases and hope for treatment in Bachmann-Bupp syndrome.
Topics: Adolescent; Adult; Alopecia; Brain; Child; Child, Preschool; Developmental Disabilities; Dicarboxyli | 2021 |
Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease.
Topics: Alopecia; Child, Preschool; Dicarboxylic Acid Transporters; Drug Repositioning; Eflornithine; Exome | 2021 |
Biochemical features of primary cells from a pediatric patient with a gain-of-function
Topics: Alopecia; Biopsy; Cells, Cultured; Child, Preschool; Dermis; Developmental Disabilities; Dicarboxyli | 2019 |
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
Topics: Administration, Oral; Alopecia; Animals; Benz(a)Anthracenes; Carcinogens; Carcinoma, Squamous Cell; | 2003 |