eflornithine has been researched along with Alloxan Diabetes in 12 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The underlying pathophysiology of type 1 diabetes involves autoimmune-mediated islet inflammation, leading to dysfunction and death of insulin-secreting islet β cells." | 1.40 | Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy. ( Colvin, SC; Maier, B; Mirmira, RG; Tersey, SA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tersey, SA | 1 |
| Colvin, SC | 1 |
| Maier, B | 1 |
| Mirmira, RG | 1 |
| Giordano, CR | 1 |
| Roberts, R | 1 |
| Krentz, KA | 1 |
| Bissig, D | 1 |
| Talreja, D | 1 |
| Kumar, A | 1 |
| Terlecky, SR | 1 |
| Berkowitz, BA | 1 |
| Miracle, CM | 1 |
| Rieg, T | 1 |
| Mansoury, H | 1 |
| Vallon, V | 2 |
| Thomson, SC | 2 |
| Ishizaki, E | 1 |
| Fukumoto, M | 1 |
| Puro, DG | 1 |
| Tovar, A | 1 |
| Sánchez-Capelo, A | 1 |
| Cremades, A | 1 |
| Peñafiel, R | 1 |
| Pedersen, SB | 2 |
| Bjørn, SF | 1 |
| Richelsen, B | 2 |
| Flyvbjerg, A | 2 |
| Younoszai, MK | 4 |
| Parekh, VV | 4 |
| Hoffman, JL | 4 |
| Stephen, TC | 1 |
| Deng, A | 1 |
| Bao, D | 1 |
| Satriano, J | 1 |
| Blantz, RC | 1 |
12 other studies available for eflornithine and Alloxan Diabetes
| Article | Year |
|---|---|
Protective effects of polyamine depletion in mouse models of type 1 diabetes: implications for therapy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Re | 2014 |
Catalase therapy corrects oxidative stress-induced pathophysiology in incipient diabetic retinopathy.
Topics: Animals; Antioxidants; Catalase; Cell Culture Techniques; Diabetes Mellitus, Experimental; Diabetic | 2015 |
Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt.
Topics: Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Efl | 2008 |
Functional K(ATP) channels in the rat retinal microvasculature: topographical distribution, redox regulation, spermine modulation and diabetic alteration.
Topics: Adenosine; Animals; Arterioles; Capillaries; Diabetes Mellitus, Experimental; Dithionitrobenzoic Aci | 2009 |
An evaluation of the role of polyamines in different models of kidney hypertrophy in mice.
Topics: Alloxan; Animals; Biogenic Polyamines; Diabetes Mellitus, Experimental; Eflornithine; Female; Hypert | 1995 |
Inhibition of renal ornithine decarboxylase activity fails to reduce kidney size and urinary albumin excretion in diabetic rats with manifest kidney hypertrophy.
Topics: Albuminuria; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diuresis; Eflorni | 1995 |
Polyamines and intestinal epithelial hyperplasia in streptozotocin-diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Eflornithine; Epithelium; Hyperplasia; Intest | 1993 |
Inhibition of renal ornithine decarboxylase activity prevents kidney hypertrophy in experimental diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Eflornithine; Hypertrophy; Insulin; Kidney; Male; Organ Si | 1993 |
Relation of ornithine decarboxylase and tyrosine kinase activity in the jejunal mucosa in vivo.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; DNA; Drinking; Eating; Eflornithine; Electrop | 1996 |
Effects of diabetes and difluoromethylornithine treatment on hyperplasia, activity of MAP-kinase, and activity and association with cyclin B of p34cdc2 kinase in rat jejunal mucosa.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cyclin B; Diabetes Melli | 1998 |
Role of tyrosine kinase, ODC, and p34cdc2 kinase and cyclin B-associated cdc2 in jejunal enterocyte proliferation, maturation, and exfoliation in diabetic and DFMO-treated rats.
Topics: Animals; Biomarkers; CDC2 Protein Kinase; Cell Division; Cyclin B; Cyclin-Dependent Kinase-Activatin | 1999 |
Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes.
Topics: Animals; Carboxy-Lyases; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Eflornithine; Enzy | 2001 |