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eflornithine and African Lymphoma

eflornithine has been researched along with African Lymphoma in 7 studies

Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.

Research Excerpts

ExcerptRelevanceReference
"alpha-Difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, was administered in combination with human leukocyte interferon to human lymphoblastoid (Daudi) cells in culture."1.27Synergistic antiproliferative activity of leukocyte interferon in combination with alpha-difluoromethylornithine against human cells in culture. ( Gutterman, JU; Rosenblum, MG, 1984)
" When doxorubicin hydrochloride (Adriamycin) was combined with DFMO, synergistic effects were noted at both DFMO concentrations."1.27Effect of alpha-difluoromethylornithine alone and in combination with doxorubicin hydrochloride, cis-diamminedichloroplatinum (II), and vinblastine sulfate on the growth of P3J cells in vitro. ( Allen, ED; Natale, RB, 1986)
"Annulate lamellae form in P3J, a Burkitt's lymphoma cell line, treated with alpha-difluoromethylornithine (DFMO), an inhibitor of polyamine synthesis."1.27Induction of annulate lamellae by alpha-difluoromethylornithine in P3J, a Burkitt's lymphoma cell line. ( Allen, ED, 1988)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19905 (71.43)18.7374
1990's2 (28.57)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rosenblum, MG1
Gutterman, JU1
Lin, CK1
Zou, HY1
Kaptein, JS1
Yen, CF1
Kalunta, CI1
Nguyen, TT1
Park, E1
Lad, PM1
Kamada, N1
Allen, ED3
Natale, RB1
Ducore, JM1

Other Studies

7 other studies available for eflornithine and African Lymphoma

ArticleYear
Synergistic antiproliferative activity of leukocyte interferon in combination with alpha-difluoromethylornithine against human cells in culture.
    Cancer research, 1984, Volume: 44, Issue:6

    Topics: Antineoplastic Agents; Burkitt Lymphoma; Cell Line; Cell Survival; Drug Synergism; Eflornithine; Hum

1984
Anti-IgM-induced growth inhibition and apoptosis are independent of ornithine decarboxylase in Ramos cells.
    Experimental cell research, 1997, Nov-25, Volume: 237, Issue:1

    Topics: Apoptosis; Burkitt Lymphoma; Cell Division; Eflornithine; Humans; Immunoglobulin M; Kinetics; Models

1997
[Inhibitory effects of interferon and inhibitors of polyamine biosynthesis on clonal growth of Raji cells derived from Burkitt's lymphoma].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1991, Volume: 66, Issue:1

    Topics: 2',5'-Oligoadenylate Synthetase; Biogenic Polyamines; Burkitt Lymphoma; Colony-Forming Units Assay;

1991
Effect of alpha-difluoromethylornithine alone and in combination with doxorubicin hydrochloride, cis-diamminedichloroplatinum (II), and vinblastine sulfate on the growth of P3J cells in vitro.
    Cancer research, 1986, Volume: 46, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cell Cycle; Cell Line; Cell Surviv

1986
alpha-Difluoromethylornithine effects on nitrosourea-induced cytotoxicity and crosslinking in a methylation excision repair positive (MER+) human cell line.
    Biochemical pharmacology, 1987, Jul-01, Volume: 36, Issue:13

    Topics: Burkitt Lymphoma; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Eflornithine; Ethylnitrosou

1987
Induction of annulate lamellae by alpha-difluoromethylornithine in P3J, a Burkitt's lymphoma cell line.
    Journal of ultrastructure and molecular structure research, 1988, Volume: 98, Issue:1

    Topics: Burkitt Lymphoma; Cell Line; Eflornithine; Endoplasmic Reticulum; Humans; Microscopy, Electron; Tumo

1988
Dissociation of annulate lamellae in P3J, a Burkitt's lymphoma cell line.
    Journal of ultrastructure and molecular structure research, 1988, Volume: 98, Issue:2

    Topics: Burkitt Lymphoma; Cell Line; Cytoplasmic Granules; Eflornithine; Humans; Microscopy, Electron; Putre

1988
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