eflornithine has been researched along with African Lymphoma in 7 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "alpha-Difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, was administered in combination with human leukocyte interferon to human lymphoblastoid (Daudi) cells in culture." | 1.27 | Synergistic antiproliferative activity of leukocyte interferon in combination with alpha-difluoromethylornithine against human cells in culture. ( Gutterman, JU; Rosenblum, MG, 1984) |
| " When doxorubicin hydrochloride (Adriamycin) was combined with DFMO, synergistic effects were noted at both DFMO concentrations." | 1.27 | Effect of alpha-difluoromethylornithine alone and in combination with doxorubicin hydrochloride, cis-diamminedichloroplatinum (II), and vinblastine sulfate on the growth of P3J cells in vitro. ( Allen, ED; Natale, RB, 1986) |
| "Annulate lamellae form in P3J, a Burkitt's lymphoma cell line, treated with alpha-difluoromethylornithine (DFMO), an inhibitor of polyamine synthesis." | 1.27 | Induction of annulate lamellae by alpha-difluoromethylornithine in P3J, a Burkitt's lymphoma cell line. ( Allen, ED, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosenblum, MG | 1 |
| Gutterman, JU | 1 |
| Lin, CK | 1 |
| Zou, HY | 1 |
| Kaptein, JS | 1 |
| Yen, CF | 1 |
| Kalunta, CI | 1 |
| Nguyen, TT | 1 |
| Park, E | 1 |
| Lad, PM | 1 |
| Kamada, N | 1 |
| Allen, ED | 3 |
| Natale, RB | 1 |
| Ducore, JM | 1 |
7 other studies available for eflornithine and African Lymphoma
| Article | Year |
|---|---|
Synergistic antiproliferative activity of leukocyte interferon in combination with alpha-difluoromethylornithine against human cells in culture.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cell Line; Cell Survival; Drug Synergism; Eflornithine; Hum | 1984 |
Anti-IgM-induced growth inhibition and apoptosis are independent of ornithine decarboxylase in Ramos cells.
Topics: Apoptosis; Burkitt Lymphoma; Cell Division; Eflornithine; Humans; Immunoglobulin M; Kinetics; Models | 1997 |
[Inhibitory effects of interferon and inhibitors of polyamine biosynthesis on clonal growth of Raji cells derived from Burkitt's lymphoma].
Topics: 2',5'-Oligoadenylate Synthetase; Biogenic Polyamines; Burkitt Lymphoma; Colony-Forming Units Assay; | 1991 |
Effect of alpha-difluoromethylornithine alone and in combination with doxorubicin hydrochloride, cis-diamminedichloroplatinum (II), and vinblastine sulfate on the growth of P3J cells in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cell Cycle; Cell Line; Cell Surviv | 1986 |
alpha-Difluoromethylornithine effects on nitrosourea-induced cytotoxicity and crosslinking in a methylation excision repair positive (MER+) human cell line.
Topics: Burkitt Lymphoma; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Eflornithine; Ethylnitrosou | 1987 |
Induction of annulate lamellae by alpha-difluoromethylornithine in P3J, a Burkitt's lymphoma cell line.
Topics: Burkitt Lymphoma; Cell Line; Eflornithine; Endoplasmic Reticulum; Humans; Microscopy, Electron; Tumo | 1988 |
Dissociation of annulate lamellae in P3J, a Burkitt's lymphoma cell line.
Topics: Burkitt Lymphoma; Cell Line; Cytoplasmic Granules; Eflornithine; Humans; Microscopy, Electron; Putre | 1988 |