eflornithine has been researched along with Adenocarcinoma in 59 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have investigated effects of alpha-difluoromethylornithine (DFMO), both as a single agent and in combination with 5-fluorouracil (5-FU) against a human colon tumor xenograft (T6) grown as primary tissue culture in serum-free medium and in combination with doxorubicin (DX) against a human lung adenocarcinoma cell line (A549)." | 7.68 | In vitro response of a human colon tumor xenograft and a lung adenocarcinoma cell line to alpha-difluoromethylornithine alone and in combination with 5-fluorouracil and doxorubicin. ( Atabek, U; Zirvi, KA, 1991) |
| "The effects of human recombinant interferon-alpha 2 (IFN-alpha 2) and alpha-difluoromethylornithine (DFMO) as single agents and in combination were studied for efficacy against the renal cell adenocarcinoma (JDF-1) in an in vitro clonogenic assay and in vivo as xenografts in nude mice." | 7.67 | Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice. ( Fleischmann, J; Heston, WD; Ratliff, TL; Tackett, RE, 1984) |
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia." | 7.67 | Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984) |
| "The depletion of polyamines by alpha-difluoromethylornithine (DFMO) treatment of mice after subcutaneous inoculation of adenocarcinoma M3 cells caused a remarkable inhibition in the growth rate of primary tumors as well as in the occurrence and number of lung metastases with a concomitant increase in survival time." | 7.67 | Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice. ( Algranati, ID; de Lustig, ES; Klein, S; Miret, JJ, 1985) |
| "Because alpha-difluoromethylornithine (DFMO) reduces the incidence of experimental colon cancers, inhibits the growth of human lung cancer cells and human leukemia cells in culture, and in combination with methylglyoxal (bis)guanylhydrazone induces remission in children with leukemia, its effectiveness against a human colon adenocarcinoma cell line (Colo 205) was tested alone and in combination with 5-fluorouracil (5-FU)." | 7.66 | Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line. ( Diekema, KA; Kingsnorth, AN; Malt, RA; McCann, PP; Russell, WE, 1983) |
| "We have investigated effects of alpha-difluoromethylornithine (DFMO), both as a single agent and in combination with 5-fluorouracil (5-FU) against a human colon tumor xenograft (T6) grown as primary tissue culture in serum-free medium and in combination with doxorubicin (DX) against a human lung adenocarcinoma cell line (A549)." | 3.68 | In vitro response of a human colon tumor xenograft and a lung adenocarcinoma cell line to alpha-difluoromethylornithine alone and in combination with 5-fluorouracil and doxorubicin. ( Atabek, U; Zirvi, KA, 1991) |
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal-bis-guanylhydrazone (MGBG), when administered simultaneously, inhibited growth and were highly toxic to the Dunning R 3327-G hormone-resistant prostatic adenocarcinoma transplanted into Copenhagen rats." | 3.67 | Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor. ( Herr, HW; Kleinert, EL, 1984) |
| "The effects of human recombinant interferon-alpha 2 (IFN-alpha 2) and alpha-difluoromethylornithine (DFMO) as single agents and in combination were studied for efficacy against the renal cell adenocarcinoma (JDF-1) in an in vitro clonogenic assay and in vivo as xenografts in nude mice." | 3.67 | Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice. ( Fleischmann, J; Heston, WD; Ratliff, TL; Tackett, RE, 1984) |
| "alpha-Difluoromethylornithine (DFMO) and methylglyoxal bis-(guanylhydrazone) (MGBG) were tested against a murine renal adenocarcinoma, because polyamines are necessary for neoplastic cell growth and because human renal adenocarcinomas contain higher levels of spermidine than do normal renal cells; MGBG inhibits spermidine synthesis and has some activity against human renal tumors; DFMO irreversibly inhibits ornithine decarboxylase, the first rate-limiting enzyme controlling polyamine biosynthesis; and DFMO promotes intracellular accumulation of MGBG in experimental tumor models and human leukemia." | 3.67 | Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice. ( Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF, 1984) |
| "We have studied the effect of pretreatment with difluoromethylornithine (DFMO), an ornithine decarboxylase inhibitor, on the cytocidal responses of four human adenocarcinoma cell lines to Adriamycin (ADR)." | 3.67 | Reduced cytocidal efficacy for adriamycin in cultured human carcinoma cells depleted of polyamines by difluoromethylornithine treatment. ( Block, AL; Komar, KA; Naujokas, MF; Seidenfeld, J, 1986) |
| "We investigated the effect of pretreatment with difluoromethylornithine (DFMO), an ornithine decarboxylase inhibitor, on the cytocidal responses of four human adenocarcinoma cell lines to two alkylating and crosslinking agents: chlorambucil and N,N',N"-triethylenethiophosphoramide (thiotepa)." | 3.67 | Effects of DFMO-induced polyamine depletion on human tumor cell sensitivity to antineoplastic DNA-crosslinking drugs. ( Block, AL; Komar, KA; Naujokas, MF; Seidenfeld, J, 1986) |
| "The depletion of polyamines by alpha-difluoromethylornithine (DFMO) treatment of mice after subcutaneous inoculation of adenocarcinoma M3 cells caused a remarkable inhibition in the growth rate of primary tumors as well as in the occurrence and number of lung metastases with a concomitant increase in survival time." | 3.67 | Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice. ( Algranati, ID; de Lustig, ES; Klein, S; Miret, JJ, 1985) |
| "Difluoromethylornithine (DFMO) and methylglyoxal bis (guanylhydrazone) (MGBG), inhibitors of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AMDC), respectively, were tested for antitumor activity in the BALB/C mouse renal adenocarcinoma model, wherein ODC and AMDC activity are elevated compared to the normal kidney." | 3.66 | Experimental chemotherapy in a transplantable renal adenocarcinoma. I: Effects of some inhibitors of polyamine synthesis. ( Dunzendorfer, U; Kleinert, E; Whitmore, WF, 1983) |
| "Because alpha-difluoromethylornithine (DFMO) reduces the incidence of experimental colon cancers, inhibits the growth of human lung cancer cells and human leukemia cells in culture, and in combination with methylglyoxal (bis)guanylhydrazone induces remission in children with leukemia, its effectiveness against a human colon adenocarcinoma cell line (Colo 205) was tested alone and in combination with 5-fluorouracil (5-FU)." | 3.66 | Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line. ( Diekema, KA; Kingsnorth, AN; Malt, RA; McCann, PP; Russell, WE, 1983) |
| "As case study, colon cancer HT-29 cells, a human cell model to investigate colon cancer, are employed." | 1.42 | Metabolomics of adherent mammalian cells by capillary electrophoresis-mass spectrometry: HT-29 cells as case study. ( Campone, L; Cifuentes, A; García-Cañas, V; Ibáñez, C; Piccinelli, AL; Simó, C; Valdés, A, 2015) |
| "1 mmol/l) was administered in combination with IFN beta (100 and 1000 IU/ml), synergistic antiproliferative activity was observed 7 days after continuous exposure." | 1.28 | Synergistic antiproliferative activity of human fibroblast interferon in combination with alpha-difluoromethylornithine against human gastric cancer cells in vitro. ( Kubota, S, 1992) |
| " ODC gene dosage was analyzed by Southern blot hybridization and was 4- to 12-fold higher in T-47D, MDA-MB-231, and BT-20 cell lines than in the MCF-7 cell line." | 1.28 | Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells. ( Jänne, OA; Kiang, DT; Thomas, T; Thomas, TJ, 1991) |
| "A clone of human gastric cancer cells (AGS-6) and the parental line (AGS-P) from which it was isolated were used in cell survival studies to determine whether pretreatment for 24, 48 or 72h with alpha-difluoromethylornithine (DFMO, 5mM) would increase the cell's sensitivity to 5-Fluorouracil (5FU), Adriamycin (Adria), 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (MeCCNU), or Bleomycin (Bleo)." | 1.28 | Schedule dependent potentiation of antitumor drug effects by alpha-difluoromethylornithine in human gastric carcinoma cells in vitro. ( Barranco, SC; Ford, PJ; Ho, BY; Koester, SK; Reumont, KJ; Townsend, CM, 1990) |
| "Putrescine is a potential scanning agent for metastases of prostatic carcinoma." | 1.27 | alpha-Difluoromethylornithine enhancement of 14C-putrescine uptake by an androgen-dependent prostatic tumor. ( Heston, WD; Kadmon, D, 1986) |
| "CsA had inhibitory effects on MC-26 colon cancer growth which were similar to DFMO; these effects were blocked by the addition of the polyamine, putrescine." | 1.27 | Effects of cyclosporine and alpha-difluoromethylornithine on the growth of mouse colon cancer in vitro. ( Barranco, SC; Saydjari, R; Thompson, JC; Townsend, CM, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (52.54) | 18.7374 |
| 1990's | 19 (32.20) | 18.2507 |
| 2000's | 6 (10.17) | 29.6817 |
| 2010's | 3 (5.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Half, E | 1 |
| Arber, N | 1 |
| Ibáñez, C | 1 |
| Simó, C | 1 |
| Valdés, A | 1 |
| Campone, L | 1 |
| Piccinelli, AL | 1 |
| García-Cañas, V | 1 |
| Cifuentes, A | 1 |
| Janakiram, NB | 1 |
| Mohammed, A | 1 |
| Bryant, T | 1 |
| Zhang, Y | 1 |
| Brewer, M | 1 |
| Duff, A | 1 |
| Biddick, L | 1 |
| Singh, A | 1 |
| Lightfoot, S | 1 |
| Steele, VE | 2 |
| Rao, CV | 1 |
| Dunzendorfer, U | 4 |
| Kingsnorth, AN | 2 |
| McCann, PP | 2 |
| Diekema, KA | 2 |
| Ross, JS | 1 |
| Malt, RA | 2 |
| Kleinert, E | 1 |
| Whitmore, WF | 4 |
| Russell, WE | 1 |
| Herr, HW | 4 |
| Kleinert, EL | 3 |
| Relyea, NM | 1 |
| Releyea, N | 1 |
| Fogh, J | 1 |
| Balis, ME | 1 |
| Heston, WD | 2 |
| Fleischmann, J | 1 |
| Tackett, RE | 1 |
| Ratliff, TL | 1 |
| Conti, PS | 1 |
| Burchenal, JH | 2 |
| Jasnis, MA | 1 |
| Klein, S | 3 |
| Monte, M | 1 |
| Davel, L | 1 |
| Sacerdote de Lustig, E | 1 |
| Algranati, ID | 3 |
| Wallon, UM | 1 |
| Shassetz, LR | 1 |
| Cress, AE | 1 |
| Bowden, GT | 1 |
| Gerner, EW | 1 |
| Lehnert, T | 1 |
| Buhl, K | 1 |
| Ivankovic, S | 1 |
| Blount, LV | 1 |
| Cooke, DB | 2 |
| Cipolla, B | 2 |
| Blanchard, Y | 1 |
| Chamaillard, L | 1 |
| Quemener, V | 2 |
| Guillé, F | 2 |
| Havouis, R | 2 |
| Moulinoux, JP | 2 |
| Das, B | 2 |
| Rao, AR | 1 |
| Madhubala, R | 2 |
| Tanakamaru, Z | 1 |
| Nishikawa, A | 1 |
| Furukawa, F | 1 |
| Imazawa, T | 1 |
| Lee, IS | 1 |
| Kasahara, K | 1 |
| Tanaka, T | 1 |
| Takahashi, M | 1 |
| Montironi, R | 1 |
| Mazzucchelli, R | 1 |
| Marshall, JR | 1 |
| Bartels, PH | 1 |
| Vig, M | 1 |
| Khurana, KK | 1 |
| Gupta, S | 1 |
| Ahmad, N | 1 |
| Marengo, SR | 1 |
| MacLennan, GT | 1 |
| Greenberg, NM | 1 |
| Mukhtar, H | 1 |
| Gunning, WT | 1 |
| Kramer, PM | 1 |
| Lubet, RA | 1 |
| Pereira, MA | 1 |
| Villano, PJ | 1 |
| Gallice, PM | 1 |
| Nicoara, AE | 1 |
| Honore, SG | 1 |
| Owczarczak, K | 1 |
| Favre, RG | 1 |
| Briand, CM | 1 |
| Donald, CD | 1 |
| Cooper, CR | 1 |
| Harris-Hooker, S | 1 |
| Emmett, N | 1 |
| Scanlon, M | 1 |
| Umar, A | 1 |
| Viner, JL | 1 |
| Hawk, ET | 1 |
| Twentyman, PR | 1 |
| Wright, KA | 1 |
| Wallace, HM | 1 |
| Yu, D | 1 |
| Seitz, PK | 1 |
| Selvanayagam, P | 1 |
| Rajaraman, S | 2 |
| Townsend, CM | 8 |
| Cooper, CW | 1 |
| Garewal, HS | 1 |
| Kubota, S | 1 |
| Thomas, T | 1 |
| Kiang, DT | 1 |
| Jänne, OA | 1 |
| Thomas, TJ | 1 |
| Barranco, SC | 6 |
| Ho, BY | 1 |
| Reumont, KJ | 1 |
| Koester, SK | 1 |
| Ford, PJ | 1 |
| Zirvi, KA | 1 |
| Atabek, U | 1 |
| Martin, C | 1 |
| Lobel, B | 1 |
| Seiler, N | 1 |
| Saydjari, R | 4 |
| Alexander, RW | 1 |
| Upp, JR | 2 |
| Thompson, JC | 6 |
| Johnson, M | 1 |
| Shaw, M | 2 |
| Rubenstein, M | 2 |
| Guinan, P | 2 |
| Reddy, BS | 1 |
| Nayini, J | 1 |
| Tokumo, K | 1 |
| Rigotty, J | 1 |
| Zang, E | 1 |
| Kelloff, G | 1 |
| Knöner, M | 1 |
| Ip, C | 1 |
| Thompson, HJ | 1 |
| Waldrop, RD | 1 |
| Rubin, NH | 1 |
| Rayford, PL | 1 |
| Carvalho, L | 1 |
| Foulkes, K | 1 |
| Mickey, DD | 1 |
| de Lustig, ES | 2 |
| Fuchs, A | 1 |
| Seidenfeld, J | 3 |
| Komar, KA | 2 |
| Naujokas, MF | 2 |
| Block, AL | 3 |
| Kadmon, D | 1 |
| Warrel, RP | 1 |
| Joseph, A | 1 |
| Davenport, C | 1 |
| Kwock, L | 1 |
| Burt, CT | 1 |
| London, RE | 1 |
| Chang, BK | 2 |
| Gutman, R | 2 |
| Chou, TC | 1 |
| Black, O | 1 |
| Barnes, D | 1 |
| Erickson, LC | 1 |
| Marx, M | 1 |
| Glass, EJ | 1 |
| Levasseur, S | 1 |
| Poleck, T | 1 |
| Burke, G | 1 |
| Shaw, MW | 1 |
| Guinan, PD | 1 |
| McKiel, CF | 1 |
| Dubin, A | 1 |
| Shrestha, RD | 1 |
| Fujimoto, S | 1 |
| Okui, K | 1 |
| Beauchamp, RD | 1 |
| Singh, P | 1 |
| James, E | 1 |
| Miret, JJ | 1 |
| Holinka, CF | 1 |
| Gurpide, E | 1 |
4 reviews available for eflornithine and Adenocarcinoma
| Article | Year |
|---|---|
Chemoprevention of gastrointestinal neoplasia.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemoprevention; Col | 2013 |
Prostate cancer prevention: review of target populations, pathological biomarkers, and chemopreventive agents.
Topics: Adenocarcinoma; Androgen Antagonists; Animals; Antineoplastic Agents; Clinical Trials as Topic; Diet | 1999 |
The future of colon cancer prevention.
Topics: Adenocarcinoma; Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; | 2001 |
Chemoprevention of Barrett's esophagus and oral leukoplakia.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Barrett Esophagus; Biomarkers; Carcinoma, Squamous Cell; Ca | 1992 |
1 trial available for eflornithine and Adenocarcinoma
| Article | Year |
|---|---|
Chemoprevention of Barrett's esophagus and oral leukoplakia.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Barrett Esophagus; Biomarkers; Carcinoma, Squamous Cell; Ca | 1992 |
55 other studies available for eflornithine and Adenocarcinoma
| Article | Year |
|---|---|
Metabolomics of adherent mammalian cells by capillary electrophoresis-mass spectrometry: HT-29 cells as case study.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Adhesion; Cell Proliferation; Colonic Neoplasms; Eflorni | 2015 |
Potentiating NK cell activity by combination of Rosuvastatin and Difluoromethylornithine for effective chemopreventive efficacy against Colon Cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; beta Catenin; Colonic Neoplasms; Cyclin D1; Disease | 2016 |
The effect of alpha-difluoromethyl-ornithine on tumor growth, acute phase reactants, beta-2-microglobulin and hydroxyproline in kidney and bladder carcinomas.
Topics: 17-Ketosteroids; Adenocarcinoma; Adult; Aged; alpha 1-Antitrypsin; Antineoplastic Agents; beta 2-Mic | 1981 |
Effects of alpha-difluoromethylornithine on the growth of experimental Wilms' tumor and renal adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Eflornithine; Kidney N | 1983 |
Experimental chemotherapy in a transplantable renal adenocarcinoma. I: Effects of some inhibitors of polyamine synthesis.
Topics: Adenocarcinoma; Animals; Eflornithine; Guanidines; Kidney; Kidney Neoplasms; Mice; Mice, Inbred BALB | 1983 |
Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Survival; Eflornithine; Fluoroura | 1983 |
Potentiation of methylglyoxal-bis-guanylhydrazone by alpha-difluoromethylornithine in rat prostate cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line; Dru | 1984 |
Some effects of inhibitors of polyamine synthesis on experimental prostatic cancer.
Topics: Adenine; Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Gu | 1984 |
Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor.
Topics: Adenocarcinoma; Animals; Body Weight; Cell Division; Drug Therapy, Combination; Eflornithine; Guanid | 1984 |
Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cell Line; Clone Cells; Drug Synergis | 1984 |
Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Division; Drug Synergism; Eflornit | 1984 |
Polyamines prevent DFMO-mediated inhibition of angiogenesis.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Eflornithine; Female; Lymphocytes; Mammary Neoplasms, | 1994 |
Polyamine-dependent expression of the matrix metalloproteinase matrilysin in a human colon cancer-derived cell line.
Topics: Adenocarcinoma; Antibody Specificity; Biogenic Polyamines; Blotting, Western; Cell Division; Colonic | 1994 |
Inhibition of gastric tumorigenesis by alpha-difluoromethylornithine in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Adenocarcinoma; Adenoma; Animals; Cell Transformation, Neoplastic; Duodenal Neoplasms; Eflornithine; | 1993 |
Genomic methylation patterns of the Dunning R-3327 prostate adenocarcinoma system.
Topics: Adenocarcinoma; Antineoplastic Agents; DNA, Neoplasm; Eflornithine; Humans; Male; Methylation; Prost | 1996 |
In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Co | 1996 |
Difluoromethylornithine antagonizes taxol cytotoxicity in MCF-7 human breast cancer cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Sur | 1997 |
Failure of dietary alpha-difluoromethylornithine to inhibit gastric carcinogenesis in rats after 8 weeks of treatment with N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Topics: Adenocarcinoma; Animals; Cell Division; Chemoprevention; Eflornithine; Male; Methylnitronitrosoguani | 1997 |
Isolation and characterization of human breast adenocarcinoma cells made resistant to alpha-difluoromethylornithine.
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Resi | 2000 |
Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice.
Topics: Adenocarcinoma; Administration, Oral; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Cell Divi | 2000 |
Chemoprevention of vinyl carbamate-induced lung tumors in strain A mice.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Dexamethaso | 2000 |
Polyamines secreted by cancer cells possibly account for the impairment of the human erythrocyte sodium pump activity.
Topics: Adenocarcinoma; Caco-2 Cells; Calorimetry; Cell Division; Culture Media, Conditioned; Eflornithine; | 2001 |
Cytoskeletal organization and cell motility correlates with metastatic potential and state of differentiation in prostate cancer.
Topics: Actins; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Differentiation; Cell Movement; Cytoske | 2001 |
Effects of cyclosporin A and a non-immunosuppressive analogue, O-acetyl cyclosporin A, upon the growth of parent and multidrug resistant human lung cancer cells in vitro.
Topics: Adenocarcinoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; Cel | 1992 |
Effects of vasoactive intestinal peptide on adenosine 3',5'-monophosphate, ornithine decarboxylase, and cell growth in a human colon cell line.
Topics: Adenocarcinoma; Blotting, Northern; Cell Division; Cell Line; Colonic Neoplasms; Cyclic AMP; Dose-Re | 1992 |
Synergistic antiproliferative activity of human fibroblast interferon in combination with alpha-difluoromethylornithine against human gastric cancer cells in vitro.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biogenic Polyamines; Cell Division; | 1992 |
Variations in amplification and expression of the ornithine decarboxylase gene in human breast cancer cells.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; DNA, Neoplasm; | 1991 |
Schedule dependent potentiation of antitumor drug effects by alpha-difluoromethylornithine in human gastric carcinoma cells in vitro.
Topics: Adenocarcinoma; Antineoplastic Agents; Bleomycin; Cell Cycle; Cell Survival; Doxorubicin; Drug Admin | 1990 |
In vitro response of a human colon tumor xenograft and a lung adenocarcinoma cell line to alpha-difluoromethylornithine alone and in combination with 5-fluorouracil and doxorubicin.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; Do | 1991 |
The growth of MAT-LyLu rat prostatic adenocarcinoma can be prevented in vivo by polyamine deprivation.
Topics: Adenocarcinoma; Animals; Diet; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Eflorn | 1991 |
Differential sensitivity of various human tumors to inhibition of polyamine biosynthesis in vivo.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; Eflornithine; Humans; Mice; Mice, Inbred BALB | 1991 |
Effect of early and delayed difluoromethylornithine pretreatment upon cyclophosphamide chemotherapy.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Admi | 1990 |
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Colonic Neopla | 1990 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Ca | 1985 |
New approaches to cancer chemoprevention with difluoromethylornithine and selenite.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Diet; Eflornithine; Female; Liver; Mammar | 1989 |
Photoperiod influences the growth of colon cancer in mice.
Topics: Adenocarcinoma; Animals; Body Weight; Circadian Rhythm; Colonic Neoplasms; Eflornithine; Light; Male | 1989 |
Effect of DMSO and DFMO on rat prostate tumor growth.
Topics: Adenocarcinoma; Animals; Dimethyl Sulfoxide; Disease Models, Animal; Eflornithine; Male; Neoplasm Tr | 1989 |
Long-term treatment of tumor-operated mice with high doses of alpha-difluoromethylornithine.
Topics: Adenocarcinoma; Animals; Bone Marrow; Combined Modality Therapy; Eflornithine; Female; Mammary Neopl | 1986 |
Reduced cytocidal efficacy for adriamycin in cultured human carcinoma cells depleted of polyamines by difluoromethylornithine treatment.
Topics: Adenocarcinoma; Cell Line; Cell Survival; Doxorubicin; Eflornithine; Humans; Ornithine; Polyamines | 1986 |
Effects of DFMO-induced polyamine depletion on human tumor cell sensitivity to antineoplastic DNA-crosslinking drugs.
Topics: Adenocarcinoma; Alkylating Agents; Antineoplastic Agents; Cell Line; Cell Survival; Chlorambucil; DN | 1986 |
alpha-Difluoromethylornithine enhancement of 14C-putrescine uptake by an androgen-dependent prostatic tumor.
Topics: Adenocarcinoma; Androgens; Animals; Carbon Radioisotopes; Dexamethasone; Dihydrotestosterone; Eflorn | 1986 |
Phase I trial of alpha-difluoromethyl ornithine (DFMO) and methylglyoxal bis (guanylhydrazone) (MGBG) in patients with advanced prostatic cancer.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Dr | 1986 |
Effects of cyclosporine and alpha-difluoromethylornithine on the growth of mouse colon cancer in vitro.
Topics: Adenocarcinoma; Animals; Cell Division; Colonic Neoplasms; Cyclosporins; Eflornithine; In Vitro Tech | 1987 |
Fluorine-19 NMR studies of tumor-bearing rats treated with difluoromethylornithine.
Topics: Adenocarcinoma; Animals; Eflornithine; Fluorine; Magnetic Resonance Spectroscopy; Male; Prostatic Ne | 1987 |
Schedule-dependent interaction of alpha-difluoromethylornithine and cis-diamminedichloroplatinum(II) against human and hamster pancreatic cancer cell lines.
Topics: Adenocarcinoma; Animals; Cell Line; Cisplatin; Colony-Forming Units Assay; Cricetinae; Drug Synergis | 1987 |
Combined effects of alpha-difluoromethylornithine and doxorubicin against pancreatic cancer cell lines in culture.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Doxorubicin; Dru | 1986 |
Comparison of DNA interstrand cross-linking and strand breakage by 1,3-bis(2-chloroethyl)-1-nitrosourea in polyamine-depleted and control human adenocarcinoma cells.
Topics: Adenocarcinoma; Carmustine; Cell Survival; Cells, Cultured; DNA Damage; DNA, Neoplasm; Eflornithine; | 1987 |
Treatment of hamster pancreatic cancer with alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis.
Topics: Adenocarcinoma; Animals; Body Weight; Cricetinae; Depression, Chemical; Eflornithine; Male; Mesocric | 1987 |
The effects of polyamine antimetabolites on polyamine-responsive casein kinase activity.
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Alkynes; Animals; Antineoplastic Agents; Casein Ki | 1987 |
Combination therapy using polyamine synthesis inhibitor alpha-difluoromethylornithine and adriamycin in treatment of rats carrying the Dunning R3327 MAT-LyLu prostatic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Doxorubicin; Efl | 1987 |
Contradictory antitumor efficacies produced by the combination of DNA attacking drugs and polyamine antimetabolites.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; DNA; Drug Intera | 1987 |
Inhibition of human gastric adenocarcinoma xenograft growth in nude mice by alpha-difluoromethylornithine.
Topics: Adenocarcinoma; Animals; Cell Membrane; Eflornithine; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; | 1988 |
Differential sensitivity of pancreatic and colon cancer to cyclosporine and alpha-difluoromethylornithine in vivo.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Cricetinae; Cyclosporins; Eflornithine; Mesocricetus; Mi | 1988 |
Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice.
Topics: Adenocarcinoma; Animals; Eflornithine; Lung; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; | 1985 |
Ornithine decarboxylase activity in human endometrium and endometrial cancer cells.
Topics: Adenocarcinoma; Cell Division; Cell Line; Corpus Luteum; Cycloheximide; Dactinomycin; Eflornithine; | 1985 |