eflornithine has been researched along with Acquired Immune Deficiency Syndrome in 14 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eflornithine was offered as compassionate treatment of 33 episodes of Pneumocystis carinii pneumonia in 31 patients with acquired immunodeficiency syndrome who were intolerant of and/or unresponsive to conventional trimethoprim-sulfamethoxazole or pentamidine therapy." | 7.68 | Eflornithine treatment of refractory Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. ( Boylen, CT; Gilman, TM; Heseltine, PN; Paulson, YJ; Sharma, OP, 1992) |
| " In the present study, we have prospectively assessed the use of alpha-difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, in the treatment of P carinii pneumonia in patients with AIDS who were intolerant or unresponsive to conventional drugs." | 7.67 | Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome. ( Golden, JA; Santi, DV; Sjoerdsma, A, 1984) |
| "Eflornithine is an antiprotozoal agent active against P." | 6.38 | Eflornithine for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome: a preliminary review. ( Berry, AJ; Sahai, J, 1989) |
| "The symposium provided dramatic evidence of the value of the use of polyamine inhibition via alpha-difluoromethylornithine (DFMO, eflornithine) for advances in chemotherapy of Trypanosoma brucei gambiense sleeping sickness and Pneumocystis carinii pneumonia in acquired immune deficiency syndrome (AIDS) and also for further understanding the metabolic importance of the ubiquitous polyamines in these organisms." | 5.06 | Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects. ( Bacchi, CJ; Barlow, JL; Bey, P; Clarkson, AB; McCann, PP; Schecter, PJ; Sjoerdsma, A; Walzer, PD, 1986) |
| "Eflornithine was offered as compassionate treatment of 33 episodes of Pneumocystis carinii pneumonia in 31 patients with acquired immunodeficiency syndrome who were intolerant of and/or unresponsive to conventional trimethoprim-sulfamethoxazole or pentamidine therapy." | 3.68 | Eflornithine treatment of refractory Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. ( Boylen, CT; Gilman, TM; Heseltine, PN; Paulson, YJ; Sharma, OP, 1992) |
| " In the present study, we have prospectively assessed the use of alpha-difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, in the treatment of P carinii pneumonia in patients with AIDS who were intolerant or unresponsive to conventional drugs." | 3.67 | Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome. ( Golden, JA; Santi, DV; Sjoerdsma, A, 1984) |
| "Twenty-two patients with the acquired immune deficiency syndrome (AIDS) and severe debilitating diarrhea caused by Cryptosporidium received eflornithine as therapy." | 3.67 | Intestinal crytosporidiosis treated with eflornithine: a prospective study among patients with AIDS. ( Bodey, GP; Fainstein, V; Rolston, KV, 1989) |
| "A 44-year-old man with acquired immunodeficiency syndrome (AIDS) and Pneumocystis carinii pneumonia (PCP) who suffered adverse effects from treatment with trimethoprim-sulfamethoxazole (TMP-SMX) and was then treated with pentamidine isethionate is described, and approved and investigational drugs used in the management of PCP in the AIDS patient are discussed." | 3.67 | Treatment of Pneumocystis carinii pneumonia in patients with AIDS. ( Hauptman, SP; Wordell, CJ, 1988) |
| "Eflornithine is an antiprotozoal agent active against P." | 2.38 | Eflornithine for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome: a preliminary review. ( Berry, AJ; Sahai, J, 1989) |
| "She tested positive and suspected pneumocystosis (later confirmed) and began treatment with IV Septrin and hydrocortisone." | 1.28 | A maternal death caused by AIDS. Case report. ( Barton, SE; Gazzard, B; Kell, PD; Marwood, RP; Nelson, M; Smith, DE, 1991) |
| "Eflornithine appears to be a useful salvage therapy in patients failing first-line treatments." | 1.28 | Pneumocystis carinii pneumonia treated with eflornithine in AIDS patients resistant to conventional therapy. ( Davies, S; Gazzard, B; Gleeson, J; Nelson, M; Smith, D; Youle, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (71.43) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Golden, JA | 2 |
| Sjoerdsma, A | 3 |
| Santi, DV | 2 |
| Schechter, PJ | 1 |
| Barlow, JL | 2 |
| Friedman, JH | 1 |
| Paulson, YJ | 1 |
| Gilman, TM | 2 |
| Heseltine, PN | 1 |
| Sharma, OP | 1 |
| Boylen, CT | 1 |
| Kell, PD | 1 |
| Barton, SE | 1 |
| Smith, DE | 1 |
| Nelson, M | 2 |
| Marwood, RP | 1 |
| Gazzard, B | 2 |
| Smith, D | 1 |
| Davies, S | 1 |
| Youle, M | 1 |
| Gleeson, J | 1 |
| Sahai, J | 1 |
| Berry, AJ | 1 |
| Cohen, JL | 1 |
| Ko, RJ | 1 |
| Lo, AT | 1 |
| Shields, MD | 1 |
| Rolston, KV | 1 |
| Fainstein, V | 1 |
| Bodey, GP | 1 |
| Tyms, AS | 1 |
| Barbarash, RA | 1 |
| Toll, L | 1 |
| Sahn, SA | 1 |
| McCann, PP | 1 |
| Bacchi, CJ | 1 |
| Clarkson, AB | 1 |
| Bey, P | 1 |
| Schecter, PJ | 1 |
| Walzer, PD | 1 |
| Wordell, CJ | 1 |
| Hauptman, SP | 1 |
| Catterall, JR | 1 |
| Potasman, I | 1 |
| Remington, JS | 1 |
1 review available for eflornithine and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Eflornithine for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome: a preliminary review.
Topics: Acquired Immunodeficiency Syndrome; Eflornithine; Humans; Opportunistic Infections; Pneumonia, Pneum | 1989 |
2 trials available for eflornithine and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Inhibition of polyamine biosynthesis by alpha-difluoromethylornithine in African trypanosomes and Pneumocystis carinii as a basis of chemotherapy: biochemical and clinical aspects.
Topics: Acquired Immunodeficiency Syndrome; Animals; Clinical Trials as Topic; Eflornithine; Humans; Pneumoc | 1986 |
Pneumocystis carinii pneumonia in the patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Bronchoscopy; Clinical Trials as Topic; Dapsone; Drug C | 1985 |
11 other studies available for eflornithine and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Eflornithine; Humans; Male; Middle Aged; Ornithine; Pneum | 1984 |
Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Child; Eflornithine; Female; Humans; Male; Mi | 1984 |
Thank God for rich women with mustaches.
Topics: Acquired Immunodeficiency Syndrome; Africa, Eastern; Anti-HIV Agents; Developing Countries; Drug Cos | 2001 |
Eflornithine treatment of refractory Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Eflornithine; Female; Hearing Disorders; Humans; Male; Pn | 1992 |
A maternal death caused by AIDS. Case report.
Topics: Acquired Immunodeficiency Syndrome; Adult; Eflornithine; Female; Humans; Isoniazid; Opportunistic In | 1991 |
Pneumocystis carinii pneumonia treated with eflornithine in AIDS patients resistant to conventional therapy.
Topics: Acquired Immunodeficiency Syndrome; Eflornithine; Female; Homosexuality; Humans; Male; Pentamidine; | 1990 |
High-pressure liquid chromatographic analysis of eflornithine in serum.
Topics: Acquired Immunodeficiency Syndrome; Chromatography, High Pressure Liquid; Eflornithine; Humans | 1989 |
Intestinal crytosporidiosis treated with eflornithine: a prospective study among patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cryptosporidiosis; Diarrhea; Eflornithine; Female; Humans | 1989 |
Polyamine inhibitors.
Topics: Acquired Immunodeficiency Syndrome; Animals; Eflornithine; Humans; Ornithine; Pneumonia, Pneumocysti | 1986 |
Alpha-difluoromethylornithine infusion and cardiac arrest.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiprotozoal Agents; Eflornithine; Female; Heart Arrest; | 1986 |
Treatment of Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Adult; Anti-Infective Agents; Dapsone; | 1988 |