eflornithine has been researched along with AIDS-Related Opportunistic Infections in 6 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of clindamycin plus primaquine appears to be the most effective alternative treatment for patients with P carinii pneumonia who are unresponsive to conventional antipneumocystis agents." | 4.81 | A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia. ( Maloba, B; Nagar, S; Popara, M; Smego, RA, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pastor, C | 1 |
| Lumbreras, C | 1 |
| Lizasoain, M | 1 |
| Ewig, S | 1 |
| Schäfer, H | 1 |
| Rockstroh, JK | 1 |
| Lüderitz, B | 1 |
| Keithly, JS | 1 |
| Zhu, G | 1 |
| Upton, SJ | 1 |
| Woods, KM | 1 |
| Martinez, MP | 1 |
| Yarlett, N | 1 |
| Merali, S | 1 |
| Smego, RA | 1 |
| Nagar, S | 1 |
| Maloba, B | 1 |
| Popara, M | 1 |
| Smith, DE | 1 |
| Davies, S | 1 |
| Smithson, J | 1 |
| Harding, I | 1 |
| Gazzard, BG | 1 |
2 reviews available for eflornithine and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
[Current alternatives in the treatment of Pneumocystis carinii pneumonia in patients with AIDS].
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Atovaquone; Clindamycin; Dapsone; Eflornit | 1994 |
A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia.
Topics: Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; Child; Child, Preschool; Clindamycin | 2001 |
1 trial available for eflornithine and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
Eflornithine versus cotrimoxazole in the treatment of Pneumocystis carinii pneumonia in AIDS patients.
Topics: Adrenal Cortex Hormones; AIDS-Related Opportunistic Infections; Chemotherapy, Adjuvant; Eflornithine | 1992 |
3 other studies available for eflornithine and AIDS-Related Opportunistic Infections
| Article | Year |
|---|---|
[Improved prognosis of first episode HIV associated Pneumocystis carinii pneumonia without preventive treatment: etiology and sequelae].
Topics: Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; Cause of Death; Eflornithine; Female | 1996 |
Polyamine biosynthesis in Cryptosporidium parvum and its implications for chemotherapy.
Topics: Acetyltransferases; AIDS-Related Opportunistic Infections; Animals; Carboxy-Lyases; Coccidiostats; C | 1997 |
Pneumocystis carinii polyamine catabolism.
Topics: Acetyltransferases; AIDS-Related Opportunistic Infections; Eflornithine; Enzyme Inhibitors; Humans; | 1999 |