ee-581 and Migraine-Disorders

In vivo observation of the ictal events are thought to help understanding the etiology and pathology in both epilepsy and migraine. While simultaneous recording of EEG and fMRI is actively conducted for the former, in some cases, epileptogenic activity is undetectable by EEG. Attempts to detect such abnormal brain activity by using fMRI are underway. Analysis methods for resting-state fMRI can be applicable for such purposes. For migraine, fMRI is also highly valuable in detecting series of ictal events. However, since the disease is suspected to involve abnormal neuro-vascular coupling, it is not always straightforward how to interpret the observation by vascular-dependent methods. Therefore development of non-vascular methods is critical for future advances.

Topics: Azides; Brain; Epilepsy; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Migraine Disorders; Octreotide