edrophonium has been researched along with Sensitivity and Specificity in 8 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The interpretation of the edrophonium (Tensilon) test in the diagnosis of acquired strabismus caused by myasthenia gravis has been problematic because of poorly defined endpoints and unknown sensitivity and specificity." | 7.68 | The edrophonium-Hess screen test in the diagnosis of ocular myasthenia gravis. ( Coll, GE; Demer, JL, 1992) |
| "The interpretation of the edrophonium (Tensilon) test in the diagnosis of acquired strabismus caused by myasthenia gravis has been problematic because of poorly defined endpoints and unknown sensitivity and specificity." | 3.68 | The edrophonium-Hess screen test in the diagnosis of ocular myasthenia gravis. ( Coll, GE; Demer, JL, 1992) |
| " The type of inhibition (competitive, uncompetitive, or mixed), the dissociation constants for the inhibitors, and the inhibitor dose-response curves were also determined." | 1.33 | Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition. ( Carroll, AD; Chen, Y; Ruzicka, J; Scampavia, L, 2006) |
| "Reports on association of systemic lupus erythematosus (SLE) and myasthenia gravis are sparse." | 1.31 | [Ocular myasthenic syndrome and systemic lupus erythematosus]. ( Budde, M; Gusek-Schneider, GC; Heckmann, JG; Kraus, B, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Budde, M | 1 |
| Heckmann, JG | 1 |
| Kraus, B | 1 |
| Gusek-Schneider, GC | 1 |
| Meriggioli, MN | 1 |
| Sanders, DB | 1 |
| Chen, Y | 1 |
| Carroll, AD | 1 |
| Scampavia, L | 1 |
| Ruzicka, J | 1 |
| Golnik, KC | 1 |
| Pena, R | 1 |
| Lee, AG | 1 |
| Eggenberger, ER | 1 |
| Padua, L | 1 |
| Stalberg, E | 1 |
| LoMonaco, M | 1 |
| Evoli, A | 1 |
| Batocchi, A | 1 |
| Tonali, P | 1 |
| Fitzpatrick, AP | 1 |
| Zaidi, A | 1 |
| Yossepowitch, O | 1 |
| Gillon, G | 1 |
| Baniel, J | 1 |
| Engelstein, D | 1 |
| Livne, PM | 1 |
| Coll, GE | 1 |
| Demer, JL | 1 |
2 reviews available for edrophonium and Sensitivity and Specificity
| Article | Year |
|---|---|
Advances in the diagnosis of neuromuscular junction disorders.
Topics: Botulism; Cholinesterase Inhibitors; Edrophonium; Electrodiagnosis; Electromyography; Humans; Immuno | 2005 |
Tilt methodology in reflex syncope: emerging evidence.
Topics: Central Nervous System; Cholinesterase Inhibitors; Clomipramine; Diagnosis, Differential; Edrophoniu | 2000 |
2 trials available for edrophonium and Sensitivity and Specificity
| Article | Year |
|---|---|
An ice test for the diagnosis of myasthenia gravis.
Topics: Adult; Aged; Aged, 80 and over; Blepharoptosis; Cold Temperature; Diagnostic Techniques, Ophthalmolo | 1999 |
SFEMG in ocular myasthenia gravis diagnosis.
Topics: Adult; Aged; Autoantibodies; Blepharoptosis; Cholinesterase Inhibitors; Diagnosis, Differential; Dip | 2000 |
4 other studies available for edrophonium and Sensitivity and Specificity
| Article | Year |
|---|---|
[Ocular myasthenic syndrome and systemic lupus erythematosus].
Topics: Adult; Diplopia; Edrophonium; Female; Humans; Lupus Erythematosus, Systemic; Myasthenia Gravis; Sens | 2002 |
Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition.
Topics: Acetylcholinesterase; Autoanalysis; Dipeptides; Dose-Response Relationship, Drug; Edrophonium; Flow | 2006 |
The effect of cholinergic enhancement during filling cystometry: can edrophonium chloride be used as a provocative test for overactive bladder?
Topics: Adult; Aged; Cholinergic Fibers; Cholinesterase Inhibitors; Edrophonium; Female; Humans; Male; Middl | 2001 |
The edrophonium-Hess screen test in the diagnosis of ocular myasthenia gravis.
Topics: Adult; Aged; Aged, 80 and over; Edrophonium; Female; Fixation, Ocular; Humans; Male; Middle Aged; My | 1992 |