edrophonium has been researched along with Paralysis in 11 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Paralysis: A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although edrophonium does not alter plasma cholinesterase activity, we have observed that doses of edrophonium that antagonize paralysis from other nondepolarizing muscle relaxants are less effective with mivacurium." | 7.69 | Edrophonium increases mivacurium concentrations during constant mivacurium infusion, and large doses minimally antagonize paralysis. ( Brown, R; Fisher, DM; Gruenke, L; Hart, PS; Lau, M; Miller, RD; Sharma, ML; Wright, PM, 1995) |
| " Although edrophonium does not alter plasma cholinesterase activity, we have observed that doses of edrophonium that antagonize paralysis from other nondepolarizing muscle relaxants are less effective with mivacurium." | 3.69 | Edrophonium increases mivacurium concentrations during constant mivacurium infusion, and large doses minimally antagonize paralysis. ( Brown, R; Fisher, DM; Gruenke, L; Hart, PS; Lau, M; Miller, RD; Sharma, ML; Wright, PM, 1995) |
| "Benzoquinonium (Mytolon) has been shown to produce a curare-like rather than a decamethonium-like paralysis of neuromuscular transmission in the tibialis anterior and soleus muscle of cats and the gastrocnemius muscle of hens." | 3.63 | The neuromuscular blocking action of benzoquinonium chloride in the cat and in the hen. ( BOWMAN, WC, 1958) |
| "Edrophonium was administered in incremental doses intravenously either until the fade ratio increased to 0." | 1.26 | Edrophonium antagonism of pancuronium-induced neuromuscular blockade in man: a reappraisal. ( Kopman, AF, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BOWMAN, WC | 1 |
| KLEE, A | 1 |
| JACOBSEN, B | 1 |
| MIWA, S | 1 |
| SHIMURA, S | 1 |
| Warrell, DA | 1 |
| Looareesuwan, S | 1 |
| White, NJ | 1 |
| Theakston, RD | 1 |
| Warrell, MJ | 1 |
| Kosakarn, W | 1 |
| Reid, HA | 1 |
| Hart, PS | 1 |
| Wright, PM | 1 |
| Brown, R | 1 |
| Lau, M | 1 |
| Sharma, ML | 1 |
| Miller, RD | 1 |
| Gruenke, L | 1 |
| Fisher, DM | 1 |
| Blythe, JA | 1 |
| Griffin, JP | 1 |
| Gonyea, EF | 1 |
| Kopman, AF | 1 |
| Hennart, D | 1 |
| d'Hollander, A | 1 |
| Plasman, C | 1 |
| De Jonckheere, M | 1 |
| Patrick, J | 1 |
| Lindstrom, J | 1 |
| Torda, TA | 1 |
| Sinclair, E | 1 |
| Ulyatt, DB | 1 |
| Capetola, R | 1 |
| Ferko, AP | 1 |
| Calesnick, B | 1 |
11 other studies available for edrophonium and Paralysis
| Article | Year |
|---|---|
The neuromuscular blocking action of benzoquinonium chloride in the cat and in the hen.
Topics: Acetylcholine; Animals; Cats; Chickens; Cholinesterase Inhibitors; Cholinesterases; Edrophonium; Fem | 1958 |
Side effects of the edrophonium chloride (Tensilon) test. Report of an unusual case.
Topics: Cardiovascular Agents; Edrophonium; Humans; Muscle Relaxants, Central; Musculoskeletal System; Paral | 1962 |
[Cure of motor paralysis with anticholinesterase drugs. Examination by induced electromyography and experimental use of Antirex].
Topics: Cardiovascular Agents; Cholinesterase Inhibitors; Edrophonium; Electromyography; Humans; Muscle Rela | 1962 |
Severe neurotoxic envenoming by the Malayan krait Bungarus candidus (Linnaeus): response to antivenom and anticholinesterase.
Topics: Adolescent; Adult; Antivenins; Bungarotoxins; Child; Cholinesterase Inhibitors; Edrophonium; Female; | 1983 |
Edrophonium increases mivacurium concentrations during constant mivacurium infusion, and large doses minimally antagonize paralysis.
Topics: Adolescent; Adult; Cholinesterases; Dose-Response Relationship, Drug; Drug Interactions; Edrophonium | 1995 |
Bilateral diaphragmatic paralysis in association with neurogenic disease.
Topics: Brachial Plexus; Chronic Disease; Diaphragm; Edrophonium; Humans; Male; Middle Aged; Paralysis; Peri | 1977 |
Edrophonium antagonism of pancuronium-induced neuromuscular blockade in man: a reappraisal.
Topics: Edrophonium; Evoked Potentials; Humans; Neuromuscular Junction; Pancuronium; Paralysis; Receptors, D | 1979 |
Importance of the level of paralysis recovery for a rapid antagonism of atracurium neuromuscular blockade with moderate doses of edrophonium.
Topics: Adult; Anesthesia, General; Atracurium; Edrophonium; Humans; Isoquinolines; Muscles; Neuromuscular B | 1986 |
Autoimmune response to acetylcholine receptor.
Topics: Animals; Antibody Formation; Antigens; Autoimmune Diseases; Edrophonium; Eels; Electric Organ; Elect | 1973 |
Puffer fish (tetrodotoxin) poisoning: clinical record and suggested management.
Topics: Adolescent; Animals; Arrhythmias, Cardiac; Consciousness; Edrophonium; Fishes, Poisonous; Foodborne | 1973 |
The inhibitory action of dopamine on the rat anterior tibialis muscle preparation.
Topics: Animals; Anura; Chlorpromazine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Ed | 1974 |