edrophonium has been researched along with Neuromuscular Blockade in 17 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Neuromuscular Blockade: The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study heart rate (HR), arterial blood pressure (BP) and autonomic nervous (AN) effects of edrophonium-atropine combinations during neuromuscular blockade (NMB) antagonism in sheep." | 9.13 | Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep. ( Clutton, RE; Glasby, MA, 2008) |
| "Sixty patients undergoing elective surgery procedures with a standardized desflurane-remifentanil-rocuronium anesthetic technique received either sugammadex, 4 mg/kg IV (n = 20), edrophonium, 1 mg/kg IV and atropine, 10 microg/kg IV (n = 20), or neostigmine, 70 microg/kg IV and glycopyrrolate, 14 microg/kg IV (n = 20) for reversal of neuromuscular blockade at 15 min or longer after the last dose of rocuronium using acceleromyography to record the train-of-four (TOF) responses." | 9.12 | Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine. ( Klein, K; Sacan, O; Tufanogullari, B; White, PF, 2007) |
| "Mivacurium is a short-acting non-depolarizing muscle relaxant, which is hydrolyzed by butyrylcholinesterase." | 6.61 | Reversal of mivacurium-induced neuromuscular blockade with a cholinesterase inhibitor: A systematic review. ( Brinch, JHW; Gätke, MR; Madsen, MV; Söderström, CM, 2019) |
| "To study heart rate (HR), arterial blood pressure (BP) and autonomic nervous (AN) effects of edrophonium-atropine combinations during neuromuscular blockade (NMB) antagonism in sheep." | 5.13 | Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep. ( Clutton, RE; Glasby, MA, 2008) |
| "Acetylcholinesterase inhibitors (neostigmine, edrophonium) and encapsulating agents (sugammadex and calabadion) can be used to reverse residual neuromuscular blockade (NMB)." | 4.93 | Reversing neuromuscular blockade: inhibitors of the acetylcholinesterase versus the encapsulating agents sugammadex and calabadion. ( Eikermann, M; Haerter, F, 2016) |
| "Benzoquinonium (Mytolon) has been shown to produce a curare-like rather than a decamethonium-like paralysis of neuromuscular transmission in the tibialis anterior and soleus muscle of cats and the gastrocnemius muscle of hens." | 3.63 | The neuromuscular blocking action of benzoquinonium chloride in the cat and in the hen. ( BOWMAN, WC, 1958) |
| "When edrophonium was used, no cases of recurarization were observed." | 2.84 | Effects of neostigmine or edrophonium on force of contraction when administered at a train-of-four ratio of 0.9 in anesthetized dogs. ( Campoy, L; Gleed, RD; Martin-Flores, M; Romano, M; Sakai, DM; Tseng, CT, 2017) |
| "Mivacurium is a short-acting non-depolarizing muscle relaxant, which is hydrolyzed by butyrylcholinesterase." | 2.61 | Reversal of mivacurium-induced neuromuscular blockade with a cholinesterase inhibitor: A systematic review. ( Brinch, JHW; Gätke, MR; Madsen, MV; Söderström, CM, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (17.65) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Romano, M | 1 |
| Martin-Flores, M | 2 |
| Sakai, DM | 2 |
| Tseng, CT | 1 |
| Campoy, L | 1 |
| Gleed, RD | 1 |
| Brinch, JHW | 1 |
| Söderström, CM | 1 |
| Gätke, MR | 1 |
| Madsen, MV | 1 |
| Jones, RS | 1 |
| Auer, U | 1 |
| Mosing, M | 1 |
| Haerter, F | 1 |
| Eikermann, M | 1 |
| Lee, C | 1 |
| Katz, RL | 1 |
| Savarese, JJ | 2 |
| McGilvra, JD | 1 |
| Sunaga, H | 1 |
| Belmont, MR | 2 |
| Van Ornum, SG | 1 |
| Savard, PM | 1 |
| Heerdt, PM | 1 |
| HOUGS, W | 1 |
| JOHANSEN, SH | 1 |
| BOWMAN, WC | 1 |
| Hokkanen, E | 1 |
| Suzuki, T | 1 |
| Lien, CA | 1 |
| Tjan, J | 1 |
| Sacan, O | 1 |
| White, PF | 1 |
| Tufanogullari, B | 1 |
| Klein, K | 1 |
| Clutton, RE | 1 |
| Glasby, MA | 1 |
| Brandom, BW | 1 |
| Woelfel, SK | 1 |
| Ference, A | 1 |
| Dayal, B | 1 |
| Cook, DR | 1 |
| Kerls, S | 1 |
| Driessen, JJ | 1 |
| Robertson, EN | 1 |
| Booij, LH | 1 |
| McNicholas, JJ | 1 |
| Harban, FM | 1 |
| Abdulatif, M | 1 |
| El-Sanabary, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I, Single-Site, Tri-Institutional, Open-Label, Three-Part, Dose-Escalation Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of CW002 in Healthy Adult Anesthetized Volunteers[NCT01338935] | Phase 1 | 136 participants (Actual) | Interventional | 2011-05-31 | Terminated (stopped due to Pharmacokinetic stopping criteria for the study were met.) | ||
| Comparison Between the Efficacy of Neostigmine Versus Sugammadex Reversal of Rocuronium Induced Neuromuscular Blockade In Paediatric Patients.[NCT03137290] | 80 participants (Actual) | Interventional | 2014-12-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for edrophonium and Neuromuscular Blockade
| Article | Year |
|---|---|
Reversal of mivacurium-induced neuromuscular blockade with a cholinesterase inhibitor: A systematic review.
Topics: Cholinesterase Inhibitors; Edrophonium; Humans; Mivacurium; Neostigmine; Neuromuscular Blockade; Ran | 2019 |
Reversal of neuromuscular block in companion animals.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Antidotes; Cholinesterase Inhibitors; De | 2015 |
Reversing neuromuscular blockade: inhibitors of the acetylcholinesterase versus the encapsulating agents sugammadex and calabadion.
Topics: Anesthesia Recovery Period; Anesthesia, General; Cholinesterase Inhibitors; Delayed Emergence from A | 2016 |
Clinical implications of new neuromuscular concepts and agents: so long, neostigmine! So long, sux!
Topics: Androstanols; Anesthesia Recovery Period; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Dose | 2009 |
5 trials available for edrophonium and Neuromuscular Blockade
| Article | Year |
|---|---|
Effects of neostigmine or edrophonium on force of contraction when administered at a train-of-four ratio of 0.9 in anesthetized dogs.
Topics: Anesthesia, General; Animals; Cross-Over Studies; Dogs; Edrophonium; Muscle Contraction; Neostigmine | 2017 |
Edrophonium effectively antagonizes neuromuscular block at the laryngeal adductors induced by rapacuronium, rocuronium and cisatracurium, but not mivacurium.
Topics: Adolescent; Adult; Androstanols; Atracurium; Cholinesterase Inhibitors; Edrophonium; Electric Stimul | 2003 |
Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine.
Topics: Adjuvants, Anesthesia; Aged; Androstanols; Atropine; Cholinesterase Inhibitors; Edrophonium; Female; | 2007 |
Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep.
Topics: Anesthesia; Animals; Atracurium; Atropine; Blood Pressure; Cholinesterase Inhibitors; Drug Therapy, | 2008 |
Edrophonium antagonism of cisatracurium-induced neuromuscular block: dose requirements in children and adults.
Topics: Adult; Atracurium; Child; Child, Preschool; Cholinesterase Inhibitors; Dose-Response Relationship, D | 2001 |
8 other studies available for edrophonium and Neuromuscular Blockade
| Article | Year |
|---|---|
Effects of two levels of partial neuromuscular block with atracurium on the ventilatory response to hypercapnia in anesthetized Beagles.
Topics: Animals; Atracurium; Capnography; Dexmedetomidine; Dogs; Edrophonium; Hypercapnia; Male; Neuromuscul | 2018 |
Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011.
Topics: Alkenes; Animals; Atracurium; Chemical Phenomena; Cholinesterase Inhibitors; Chromatography, High Pr | 2010 |
Effects of edrophonium and neostigmine on neuromuscular block in the cat.
Topics: Animals; Cats; Edrophonium; Felis; Muscle Relaxants, Central; Neostigmine; Neuromuscular Blockade; N | 1958 |
The neuromuscular blocking action of benzoquinonium chloride in the cat and in the hen.
Topics: Acetylcholine; Animals; Cats; Chickens; Cholinesterase Inhibitors; Cholinesterases; Edrophonium; Fem | 1958 |
THE AGGRAVATING EFFECT OF SOME ANTIBIOTICS ON THE NEUROMUSCULAR BLOCKADE IN MYASTHENIA GRAVIS.
Topics: Anti-Bacterial Agents; Dihydrostreptomycin Sulfate; Edrophonium; Kanamycin; Myasthenia Gravis; Neost | 1964 |
Effects of cisatracurium in children during halothane-nitrous oxide anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthetics, Inhalation; Antidotes; Atracurium; | 1998 |
Which is better in children: edrophonium or neostigmine?
Topics: Child; Cholinesterase Inhibitors; Edrophonium; Humans; Neostigmine; Neuromuscular Blockade | 2000 |
Anaphylaxis caused by neostigmine.
Topics: Anaphylaxis; Cholinesterase Inhibitors; Edrophonium; Humans; Neostigmine; Neuromuscular Blockade | 2000 |