edrophonium has been researched along with Lambert-Eaton Myasthenic Syndrome in 4 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Lambert-Eaton Myasthenic Syndrome: An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Uneqivocally positive edrophonium tests, both clinically and electrophysiologically, were observed in a classic case of the Lambert-Eaton myasthenic syndrome." | 7.68 | Edrophonium responsiveness not necessarily diagnostic of myasthenia gravis. ( Cho, HK; Oh, SJ, 1990) |
| "Uneqivocally positive edrophonium tests, both clinically and electrophysiologically, were observed in a classic case of the Lambert-Eaton myasthenic syndrome." | 3.68 | Edrophonium responsiveness not necessarily diagnostic of myasthenia gravis. ( Cho, HK; Oh, SJ, 1990) |
| "The case of a patient with fatigable diplopia and ptosis 3 years after removal of a large-cell lung carcinoma is presented." | 1.31 | Myasthenia gravis with a paraneoplastic marker. ( Leavitt, JA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Meriggioli, MN | 1 |
| Sanders, DB | 1 |
| Gajdos, P | 1 |
| Leavitt, JA | 1 |
| Oh, SJ | 1 |
| Cho, HK | 1 |
2 reviews available for edrophonium and Lambert-Eaton Myasthenic Syndrome
| Article | Year |
|---|---|
Advances in the diagnosis of neuromuscular junction disorders.
Topics: Botulism; Cholinesterase Inhibitors; Edrophonium; Electrodiagnosis; Electromyography; Humans; Immuno | 2005 |
[Myasthenic syndrome. Diagnostic trends].
Topics: Adult; Botulism; Cholinesterase Inhibitors; Diagnosis, Differential; Edrophonium; Electromyography; | 2000 |
2 other studies available for edrophonium and Lambert-Eaton Myasthenic Syndrome
| Article | Year |
|---|---|
Myasthenia gravis with a paraneoplastic marker.
Topics: Autoantibodies; Azathioprine; Biomarkers; Blepharoptosis; Calcium Channels; Carcinoma, Large Cell; D | 2000 |
Edrophonium responsiveness not necessarily diagnostic of myasthenia gravis.
Topics: Edrophonium; Electrophysiology; Female; Humans; Lambert-Eaton Myasthenic Syndrome; Middle Aged; Myas | 1990 |