edrophonium has been researched along with External Ophthalmoplegia in 36 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 70-year-old man with known vascular disease, who had bilateral internuclear ophthalmoplegia, and an 18-month-old girl with a long-term variable esotropia culminating in a postinfectious oculopharyngeal neuropathy both responded with a positive edrophonium chloride (Tensilon) test, strongly suggesting the diagnosis of myasthenia gravis." | 3.66 | Ocular myasthenia gravis mimicking pseudointernuclear ophthalmoplegia and variable esotropia. ( Acers, TE, 1979) |
| "In three patients with iatrogenic diplopia, static alignment was abnormal but movement range and saccadic velocities were within normal limits." | 2.69 | Clinical evidence of extraocular muscle fiber-type specificity of botulinum toxin. ( Averbuch-Heller, L; Leigh, RJ; Remler, BF; Stahl, JS, 1998) |
| "A 41-year-old woman with a history of breast cancer presented with acute onset of left hypotropia and exotropia." | 1.30 | Isolated inferior rectus palsy caused by a metastasis to the oculomotor nucleus. ( Chou, TM; Demer, JL, 1998) |
| "Three cases of ocular myasthenia gravis were observed." | 1.29 | [Ocular myasthenia: an etiology to consider in unexplained oculomotor paralysis]. ( Amarenco, P; Benrabah, R; Castelli, P; Guillaume, JB; Hamard, H; Hamard, P, 1994) |
| "The diagnosis of myasthenia gravis is usually confirmed by a Tensilon test, which can be complicated by cholinergic side effects that include cardiopulmonary arrest." | 1.28 | The sleep test for myasthenia gravis. A safe alternative to Tensilon. ( Behrens, MM; Odel, JG; Winterkorn, JM, 1991) |
| "Fifteen patients with ocular myasthenia gravis were examined in detail for 21 different signs, and tested for acetylcholine receptor antibodies." | 1.27 | An evaluation of signs in ocular myasthenia gravis and correlation with acetylcholine receptor antibodies. ( Francis, IC; Kappagoda, MB; Nicholson, GA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (83.33) | 18.7374 |
| 1990's | 5 (13.89) | 18.2507 |
| 2000's | 1 (2.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BRODY, IA | 1 |
| ENGEL, WK | 1 |
| SAKATANI, N | 1 |
| JAMPEL, RS | 1 |
| MANSON, N | 1 |
| STERN, G | 1 |
| COGAN, DG | 2 |
| Gamio, S | 1 |
| Garcia-Erro, M | 1 |
| Vaccarezza, MM | 1 |
| Minella, JA | 1 |
| Rush, JA | 1 |
| Shafrin, F | 1 |
| Gil, R | 1 |
| Lefèvre, JP | 1 |
| Huber, A | 1 |
| Kresse, L | 1 |
| Barton, JJ | 1 |
| Huaman, AG | 1 |
| Sharpe, JA | 1 |
| Castelli, P | 1 |
| Hamard, P | 1 |
| Benrabah, R | 1 |
| Guillaume, JB | 1 |
| Amarenco, P | 1 |
| Hamard, H | 1 |
| Stahl, JS | 1 |
| Averbuch-Heller, L | 1 |
| Remler, BF | 1 |
| Leigh, RJ | 1 |
| Chou, TM | 1 |
| Demer, JL | 1 |
| Osher, RH | 1 |
| Acers, TE | 1 |
| Neetens, A | 1 |
| Burvenich, H | 1 |
| Yee, RD | 1 |
| Zee, DS | 1 |
| Baloh, RW | 1 |
| Honrubia, V | 1 |
| Mumenthaler, M | 1 |
| Lütschg, J | 1 |
| Burke, WJ | 1 |
| Odel, JG | 1 |
| Winterkorn, JM | 1 |
| Behrens, MM | 1 |
| Davis, TL | 1 |
| Lavin, PJ | 1 |
| Rosenberg, ML | 1 |
| Francis, IC | 1 |
| Nicholson, GA | 1 |
| Kappagoda, MB | 1 |
| Wray, SH | 1 |
| Pavan-Langston, D | 1 |
| Brust, JC | 1 |
| List, TA | 1 |
| Catalano, LW | 1 |
| Lovelace, R | 1 |
| Shapira, Y | 1 |
| Cividalli, G | 1 |
| Szabo, G | 1 |
| Rozin, R | 1 |
| Russell, A | 1 |
| Susac, JO | 1 |
| Garcia-Mullin, R | 1 |
| Glaser, JS | 2 |
| Ishikawa, S | 1 |
| Mukuno, K | 1 |
| Cherington, M | 1 |
| Oh, SJ | 1 |
| Fischer, KC | 1 |
| Schwartzmann, RJ | 1 |
| Mathew, NT | 1 |
| Jacob, JC | 1 |
| Chandy, J | 1 |
| Jenkins, RB | 1 |
| Retzlaff, JA | 1 |
| Kearns, TP | 1 |
| Howard, FM | 1 |
| Cronin, ML | 1 |
| Wolter, M | 1 |
2 trials available for edrophonium and External Ophthalmoplegia
| Article | Year |
|---|---|
Clinical evidence of extraocular muscle fiber-type specificity of botulinum toxin.
Topics: Adult; Aged; Anti-Dyskinesia Agents; Botulinum Toxins; Botulism; Diplopia; Edrophonium; Female; Huma | 1998 |
Tensilon tonography in the diagnosis of myasthenia gravis.
Topics: Clinical Trials as Topic; Curare; Diplopia; Edrophonium; Female; Humans; Intraocular Pressure; Male; | 1967 |
34 other studies available for edrophonium and External Ophthalmoplegia
| Article | Year |
|---|---|
DENERVATION OF MUSCLE IN MYASTHENIA GRAVIS. ROPORT OF A PATIENT WITH MYASTHENIA GRAVIS FOR 47 YEARS AND HISTOCHEMICAL SIGNS OF DENERVATION.
Topics: Adenosine Triphosphatases; Biopsy; Edrophonium; Eyelids; Histocytochemistry; Humans; Muscle Denervat | 1964 |
DENERVATION POTENTIALS OF THE EXTRAOCULAR MUSCLES OF CATS AND MONKEYS.
Topics: Animals; Cats; Denervation; Edrophonium; Electroencephalography; Haplorhini; Muscle Denervation; Neu | 1964 |
DEFECTS OF NEAR VISION IN MYASTHENIA GRAVIS.
Topics: Accommodation, Ocular; Cholinesterase Inhibitors; Diagnosis; Diplopia; Drug Therapy; Edrophonium; Ey | 1965 |
MYASTHENIA GRAVIS: A REVIEW OF THE DISEASE AND A DESCRIPTION OF LID TWITCH AS A CHARACTERISTIC SIGN.
Topics: Blepharoptosis; Diagnosis; Edrophonium; Electromyography; Eye Manifestations; Eyelids; Humans; Myast | 1965 |
Myasthenia gravis in childhood.
Topics: Adult; Age of Onset; Blepharoptosis; Child; Child, Preschool; Cholinesterase Inhibitors; Diagnostic | 2004 |
Ocular myasthenia presenting as superior oblique weakness.
Topics: Adult; Blepharoptosis; Diplopia; Edrophonium; Humans; Male; Myasthenia Gravis; Ophthalmoplegia; Stra | 1982 |
[Optokinetic nystagmus and the Tensilon test in myasthenia].
Topics: Adolescent; Adult; Aged; Edrophonium; Electronystagmography; Eye; Female; Humans; Male; Middle Aged; | 1983 |
The visual system in myelin disorders. Electromyography (EMG).
Topics: Edrophonium; Electromyography; Eye Movements; Humans; Myasthenia Gravis; Myositis; Oculomotor Muscle | 1983 |
[A positive Tensilon test in hyperthyroidism? (author's transl)].
Topics: Adult; Diagnosis, Differential; Edrophonium; Female; Humans; Hyperthyroidism; Myasthenia Gravis; Oph | 1982 |
Effects of edrophonium on saccadic velocity in normal subjects and myasthenic and nonmyasthenic ocular palsies.
Topics: Adult; Aged; Edrophonium; Humans; Middle Aged; Myasthenia Gravis; Ophthalmoplegia; Saccades | 1994 |
[Ocular myasthenia: an etiology to consider in unexplained oculomotor paralysis].
Topics: Adult; Aged; Cholinesterase Inhibitors; Edrophonium; Electromyography; Humans; Male; Myasthenia Grav | 1994 |
Isolated inferior rectus palsy caused by a metastasis to the oculomotor nucleus.
Topics: Adult; Brain Neoplasms; Breast Neoplasms; Cranial Nerve Neoplasms; Edrophonium; Female; Humans; Lymp | 1998 |
Myasthenic "oculomotor" palsy.
Topics: Adult; Blepharoptosis; Diabetes Mellitus; Diabetic Neuropathies; Diagnosis, Differential; Edrophoniu | 1979 |
Ocular myasthenia gravis mimicking pseudointernuclear ophthalmoplegia and variable esotropia.
Topics: Aged; Diagnosis, Differential; Edrophonium; Esotropia; Female; Humans; Infant; Male; Myasthenia Grav | 1979 |
Superior oblique muscle palsies of muscular type.
Topics: Aged; Edema; Edrophonium; Female; Hematoma; Humans; Male; Middle Aged; Neuritis; Ophthalmoplegia; Tr | 1979 |
Rapid eye movements in myasthenia gravis. II. Electro-oculographic analysis.
Topics: Adolescent; Adult; Aged; Diagnosis, Differential; Edrophonium; Electrooculography; Eye Movements; Hu | 1976 |
[Pseudoparalytic myasthenia gravis. Diagnostic and therapeutic aspects in 60 separate cases].
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Diagnosis, Differential; Edrophonium; | 1976 |
The ocular myasthenia syndrome.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Diagnosis, Differential; Edrophonium; Female; Humans; Male | 1975 |
The sleep test for myasthenia gravis. A safe alternative to Tensilon.
Topics: Blepharoptosis; Child; Edrophonium; Female; Humans; Male; Middle Aged; Myasthenia Gravis; Ophthalmop | 1991 |
Pseudo one-and-a-half syndrome with ocular myasthenia.
Topics: Aged; Blepharoptosis; Edrophonium; Humans; Male; Muscular Diseases; Oculomotor Muscles; Ophthalmople | 1989 |
Spasm of the near reflex mimicking myasthenia gravis.
Topics: Accommodation, Ocular; Adult; Convergence, Ocular; Diagnostic Errors; Edrophonium; Eye Diseases; Fem | 1986 |
An evaluation of signs in ocular myasthenia gravis and correlation with acetylcholine receptor antibodies.
Topics: Adult; Aged; Autoantibodies; Blepharoptosis; Edrophonium; Humans; Middle Aged; Myasthenia Gravis; Op | 1985 |
A reevaluation of edrophonium chloride (Tensilon) tonography in the diagnosis of myasthenia gravis. With observations on some other defects of neuromuscular transmission.
Topics: Adolescent; Adult; Aged; Bronchial Neoplasms; Child; Edrophonium; Electromyography; Female; Humans; | 1971 |
Ocular myasthenia gravis mimicking progressive external ophthalmoplegia. Rare case of myasthenia associated with peripheral neuropathy and spastic paraparesis.
Topics: Adult; Diagnosis, Differential; Edrophonium; Electric Stimulation; Electromyography; Humans; Male; M | 1974 |
A myasthenic syndrome in childhood leukemia.
Topics: Blepharoptosis; Bone Marrow Examination; Child; Edrophonium; Electric Stimulation; Electromyography; | 1974 |
Ophthalmoplegia in dermatomyositis.
Topics: Aspartate Aminotransferases; Creatine Kinase; Dermatomyositis; Diagnosis, Differential; Edrophonium; | 1973 |
[Myasthenia gravis suspected to be oculomuscular myopathy associated with retinal degeneration and oligotrichia].
Topics: Adult; Alopecia; Diagnosis, Differential; Edrophonium; Humans; Male; Myasthenia Gravis; Ophthalmople | 1973 |
Botulism. Ten-year experience.
Topics: Adolescent; Adult; Blepharoptosis; Botulinum Antitoxin; Botulism; Colorado; Edrophonium; Electric St | 1974 |
The Eaton-Lambert syndrome in ocular myasthenia gravis.
Topics: Bronchial Neoplasms; Carcinoma; Diagnosis, Differential; Edrophonium; Electric Stimulation; Electrom | 1974 |
Oral corticosteroids in the treatment of ocular myasthenia gravis.
Topics: Administration, Oral; Adult; Aged; Blepharoptosis; Child, Preschool; Cholinesterase Inhibitors; Edro | 1974 |
Familial ocular myopathy with curare sensitivity.
Topics: Adult; Biopsy; Drug Hypersensitivity; Edrophonium; Electrodiagnosis; Electromyography; Humans; Male; | 1970 |
Pseudo-pseudointernuclear ophthalmoplegia.
Topics: Adult; Edrophonium; Female; Humans; Injections, Intravenous; Myasthenia Gravis; Nystagmus, Pathologi | 1971 |
Lancaster red-green test in evaluation of edrophonium effect in myasthenia gravis.
Topics: Adult; Aged; Blepharoptosis; Curare; Diplopia; Edrophonium; Female; Humans; Male; Methods; Myastheni | 1969 |
[The ocular form of myasthenia].
Topics: Adult; Aged; Blepharoptosis; Child; Curare; Edrophonium; Electromyography; Eyelids; Female; Humans; | 1965 |