edrophonium has been researched along with Esophageal Reflux in 17 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Strong esophageal contractions and not a decreased blood flow in the esophageal wall seem to be the cause of chest pain provoked by intravenous edrophonium chloride." | 7.69 | The effect of edrophonium chloride-induced chest pain on esophageal blood flow and motility. ( Gustafsson, U; Tibbling, L, 1997) |
| "1 N hydrochloric acid) and edrophonium (80 micrograms/kg intravenously) tests were placebo-controlled with a positive study defined as replication of typical chest pain." | 5.07 | Twenty-four-hour esophageal pH monitoring: the most useful test for evaluating noncardiac chest pain. ( Dalton, CB; Hewson, EG; Richter, JE; Sinclair, JW, 1991) |
| "Strong esophageal contractions and not a decreased blood flow in the esophageal wall seem to be the cause of chest pain provoked by intravenous edrophonium chloride." | 3.69 | The effect of edrophonium chloride-induced chest pain on esophageal blood flow and motility. ( Gustafsson, U; Tibbling, L, 1997) |
| "Fourty-four unselected patients with noncardiac chest pain were studied using conventional manometry with additional edrophonium provocation and 24-hour ambulatory esophageal pH and pressure recording with a system developed by our group." | 3.68 | Analysis of 24-hour esophageal pressure and pH data in unselected patients with noncardiac chest pain. ( Akkermans, LM; Breumelhof, R; Nadorp, JH; Smout, AJ, 1990) |
| " In 8 (24%) the pain proved to be related to oesophageal motor disorders unaccompanied by gastro-oesophageal reflux; in 12 (36%) acid reflux contributed to chest pain; but in the remaining 13 (40%) identical chest pain episodes were due to various mechanisms including reflux without motor disorders, motor disorders without reflux, motor disorders without reflux but with positive acid-perfusion test, and acid reflux without motility disorders but with positive edrophonium-stimulation test." | 3.67 | The irritable oesophagus--a frequent cause of angina-like pain. ( Ghillebert, G; Janssens, J; Vantrappen, G, 1987) |
| "A 44." | 1.32 | Prevalence of esophageal disorders in patients with recurrent chest pain. ( Barroso, MS; Losada, H; Manterola, C; Muñoz, S; Vial, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fass, R | 1 |
| Manterola, C | 1 |
| Barroso, MS | 1 |
| Losada, H | 1 |
| Muñoz, S | 1 |
| Vial, M | 1 |
| Trujillo, L | 1 |
| Hernández, MC | 1 |
| Leo, E | 1 |
| Fornari, F | 1 |
| Blondeau, K | 1 |
| Durand, L | 1 |
| Rey, E | 1 |
| Diaz-Rubio, M | 1 |
| De Meyer, A | 1 |
| Tack, J | 1 |
| Sifrim, D | 1 |
| Just, RJ | 1 |
| Castell, DO | 3 |
| Anselmino, M | 1 |
| Clark, GW | 1 |
| Hinder, RA | 1 |
| Gustafsson, U | 1 |
| Tibbling, L | 1 |
| Hookman, P | 1 |
| Barkin, JS | 1 |
| Higgs, RH | 1 |
| Farrell, RL | 2 |
| Rokkas, T | 1 |
| Anggiansah, A | 1 |
| McCullagh, M | 1 |
| Owen, WJ | 1 |
| Heijke, SA | 1 |
| Smith, G | 1 |
| Key, A | 1 |
| Hewson, EG | 1 |
| Sinclair, JW | 1 |
| Dalton, CB | 1 |
| Richter, JE | 1 |
| Breumelhof, R | 1 |
| Nadorp, JH | 1 |
| Akkermans, LM | 1 |
| Smout, AJ | 1 |
| Limburg, AJ | 1 |
| Beekhuis, H | 1 |
| van Dijk, RB | 1 |
| Kleibeuker, JH | 1 |
| Vantrappen, G | 1 |
| Janssens, J | 1 |
| Ghillebert, G | 1 |
| Lipshutz, WH | 1 |
| Gaskins, RD | 1 |
| Lukash, WM | 1 |
| Sode, J | 1 |
| Roling, GT | 1 |
3 reviews available for edrophonium and Esophageal Reflux
| Article | Year |
|---|---|
Evaluation and diagnosis of noncardiac chest pain.
Topics: Chest Pain; Cholinesterase Inhibitors; Edrophonium; Endoscopy, Gastrointestinal; Ergonovine; Esophag | 2008 |
Chest pain of undetermined origin.
Topics: Barium Sulfate; Chest Pain; Clinical Trials as Topic; Combined Modality Therapy; Drug Therapy, Combi | 1994 |
Esophageal chest pain: state of the art.
Topics: Bethanechol; Bethanechol Compounds; Calcium Channel Blockers; Chest Pain; Diagnosis, Differential; E | 1993 |
2 trials available for edrophonium and Esophageal Reflux
| Article | Year |
|---|---|
Comparison of the combined effects of atropine and neostigmine with atropine and edrophonium on the lower oesophageal sphincter.
Topics: Adult; Anesthesia, General; Atropine; Edrophonium; Esophagogastric Junction; Female; Gastroesophagea | 1991 |
Twenty-four-hour esophageal pH monitoring: the most useful test for evaluating noncardiac chest pain.
Topics: Adult; Aged; Ambulatory Care; Chest Pain; Edrophonium; Evaluation Studies as Topic; Female; Gastroes | 1991 |
12 other studies available for edrophonium and Esophageal Reflux
| Article | Year |
|---|---|
Prevalence of esophageal disorders in patients with recurrent chest pain.
Topics: Adult; Aged; Aged, 80 and over; Chest Pain; Cross-Sectional Studies; Diagnosis, Differential; Edroph | 2004 |
[Thoracic pain caused by esophageal dysfunction in patients with ischemic cardiopathy].
Topics: Acids; Adult; Aged; Angina Pectoris; Chest Pain; Diagnosis, Differential; Edrophonium; Esophageal Mo | 2007 |
Relevance of mild ineffective oesophageal motility (IOM) and potential pharmacological reversibility of severe IOM in patients with gastro-oesophageal reflux disease.
Topics: Adult; Edrophonium; Esophageal Motility Disorders; Female; Gastric Acid; Gastroesophageal Reflux; Hu | 2007 |
The effect of edrophonium chloride-induced chest pain on esophageal blood flow and motility.
Topics: Adult; Aged; Chest Pain; Cholinesterase Inhibitors; Edrophonium; Esophageal Motility Disorders; Esop | 1997 |
The diagnosis and management of unexplained chest pain--is less more?
Topics: Angina Pectoris; Chest Pain; Coronary Angiography; Coronary Disease; Diagnosis, Differential; Edroph | 1999 |
Evaluation of the effect of fundoplication on the incompetent lower esophageal sphincter.
Topics: Adult; Edrophonium; Esophagogastric Junction; Esophagus; Evaluation Studies as Topic; Gastroesophage | 1975 |
Acid perfusion and edrophonium provocation tests in patients with chest pain of undetermined etiology.
Topics: Adult; Aged; Chest Pain; Chi-Square Distribution; Circadian Rhythm; Diagnosis, Differential; Edropho | 1992 |
Analysis of 24-hour esophageal pressure and pH data in unselected patients with noncardiac chest pain.
Topics: Adult; Chest Pain; Edrophonium; Esophageal Motility Disorders; Esophagus; Female; Gastroesophageal R | 1990 |
Noncardiac chest pain: is the esophagus really a frequent source?
Topics: Chest Pain; Edrophonium; Esophageal Diseases; Esophagoscopy; Female; Gastroesophageal Reflux; Humans | 1990 |
The irritable oesophagus--a frequent cause of angina-like pain.
Topics: Adult; Aged; Angina Pectoris; Diagnosis, Differential; Edrophonium; Esophageal Diseases; Esophagosco | 1987 |
Pathogenesis of lower-esophageal-sphincter incompetence.
Topics: Adult; Aged; Bethanechol Compounds; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Edr | 1973 |
Stimulation of the incompetent lower esophageal sphincter. A possible advance in therapy of heartburn.
Topics: Adult; Aged; Bethanechol Compounds; Edrophonium; Esophagus; Female; Gastrins; Gastroesophageal Reflu | 1973 |