Page last updated: 2024-10-26

edrophonium and Dysphagia

edrophonium has been researched along with Dysphagia in 14 studies

Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.

Research Excerpts

ExcerptRelevanceReference
" However, dysphagia developed, and her voice took on a nasal tone that did not improve subjectively even after administration of 10 mg of edrophonium chloride (EC)."3.74[Videofluorographic evaluation of dysphagia in a patient with myasthenia gravis]. ( Aoki, Y; Murata, M; Ogata, K; Ogawa, M; Oya, Y; Yamamoto, T, 2007)
"Diagnosis of pharyngeal dysphagia caused by myasthenia gravis (MG) based on clinical examination alone is often challenging."1.48Reliability and main findings of the flexible endoscopic evaluation of swallowing-Tensilon test in patients with myasthenia gravis and dysphagia. ( Claus, I; Colbow, S; Dziewas, R; Im, S; Meuth, SG; Sauer, S; Suntrup-Krueger, S; Warnecke, T, 2018)
"Four severely affected patients with dysphagia as their leading symptom were examined."1.35Fiberoptic endoscopic evaluation of swallowing with simultaneous Tensilon application in diagnosis and therapy of myasthenia gravis. ( Dziewas, R; Oelenberg, S; Ringelstein, EB; Teismann, I; Warnecke, T; Zimmermann, J, 2008)
"Edrophonium continues to be a relatively sensitive test for noncardiac chest pain."1.27Comparison of hypertonic glucose to other provocative tests in patients with noncardiac chest pain. ( Hendrix, EA; Nasrallah, SM, 1987)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19907 (50.00)18.7374
1990's2 (14.29)18.2507
2000's4 (28.57)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Im, S1
Suntrup-Krueger, S1
Colbow, S1
Sauer, S1
Claus, I1
Meuth, SG1
Dziewas, R2
Warnecke, T2
Stiefelhagen, P1
STUART, WD1
Aoki, Y1
Yamamoto, T1
Ogata, K1
Oya, Y1
Ogawa, M1
Murata, M1
Teismann, I1
Zimmermann, J1
Oelenberg, S1
Ringelstein, EB1
Benjamin, SB2
Richter, JE3
Cordova, CM1
Knuff, TE1
Castell, DO2
Ngeh, JK1
McElligott, G1
Mellow, M1
Deschner, WK1
Maher, KA1
Cattau, EL1
Hewson, EG1
Dalton, CB2
Hackshaw, BT1
Wu, WC2
Vantrappen, G1
Janssens, J1
Nasrallah, SM1
Hendrix, EA1
Katz, PO1
Aronson, AE1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Transnasal Endoscopic Evaluation of Swallowing: Functional Esophagoscopy Using an Ultrathin Video Endoscope in Neurogenic Dysphagia[NCT01995929]62 participants (Actual)Observational2013-12-31Completed
Esophageal Motility Disorders in Patients With Non-cardiac Chest Pain at Assiut University Hospital[NCT05402462]90 participants (Anticipated)Observational2022-06-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

14 other studies available for edrophonium and Dysphagia

ArticleYear
Reliability and main findings of the flexible endoscopic evaluation of swallowing-Tensilon test in patients with myasthenia gravis and dysphagia.
    European journal of neurology, 2018, Volume: 25, Issue:10

    Topics: Aged; Aged, 80 and over; Deglutition; Deglutition Disorders; Edrophonium; Female; Humans; Male; Midd

2018
[Surprising etiology of chronic deglutition disorder. Diagnosis at a glance in dysphagia].
    MMW Fortschritte der Medizin, 2008, Jun-05, Volume: 150, Issue:23

    Topics: Autoantibodies; Cholinesterase Inhibitors; Deglutition Disorders; Diagnosis, Differential; Edrophoni

2008
THE OTOLARYNGOLOGIC ASPECTS OF MYASTHENIA GRAVIS.
    The Laryngoscope, 1965, Volume: 75

    Topics: Child; Cough; Deglutition Disorders; Edrophonium; Geriatrics; Humans; Myasthenia Gravis; Neostigmine

1965
[Videofluorographic evaluation of dysphagia in a patient with myasthenia gravis].
    Rinsho shinkeigaku = Clinical neurology, 2007, Volume: 47, Issue:10

    Topics: Barium; Deglutition; Deglutition Disorders; Edrophonium; Female; Fluoroscopy; Humans; Middle Aged; M

2007
Fiberoptic endoscopic evaluation of swallowing with simultaneous Tensilon application in diagnosis and therapy of myasthenia gravis.
    Journal of neurology, 2008, Volume: 255, Issue:2

    Topics: Aged, 80 and over; Cholinesterase Inhibitors; Conscious Sedation; Deglutition; Deglutition Disorders

2008
Prospective manometric evaluation with pharmacologic provocation of patients with suspected esophageal motility dysfunction.
    Gastroenterology, 1983, Volume: 84, Issue:5 Pt 1

    Topics: Adult; Aged; Bethanechol Compounds; Deglutition Disorders; Edrophonium; Esophageal Achalasia; Esopha

1983
Myasthenia gravis: an elusive diagnosis in older people.
    Journal of the American Geriatrics Society, 2001, Volume: 49, Issue:5

    Topics: Accidental Falls; Age Factors; Aged; Aged, 80 and over; Cognition Disorders; Deglutition Disorders;

2001
Symptomatic diffuse esophageal spasm. Manometric follow-up and response to cholinergic stimulation and cholinesterase inhibition.
    Gastroenterology, 1977, Volume: 73, Issue:2

    Topics: Adult; Bethanechol Compounds; Deglutition Disorders; Edrophonium; Esophageal Diseases; Esophagus; Fo

1977
Intraesophageal balloon distention versus drug provocation in the evaluation of noncardiac chest pain.
    The American journal of gastroenterology, 1990, Volume: 85, Issue:8

    Topics: Bethanechol; Bethanechol Compounds; Catheterization; Chest Pain; Coronary Disease; Deglutition Disor

1990
The prevalence of abnormal esophageal test results in patients with cardiovascular disease and unexplained chest pain.
    Archives of internal medicine, 1990, Volume: 150, Issue:5

    Topics: Acids; Adult; Aged; Angioplasty, Balloon; Cardiovascular Diseases; Chest Pain; Coronary Artery Bypas

1990
[Role of manometry in the diagnosis of motor disorders of the esophagus].
    Presse medicale (Paris, France : 1983), 1989, Mar-25, Volume: 18, Issue:12

    Topics: Chest Pain; Deglutition Disorders; Diagnosis, Differential; Edrophonium; Esophageal Diseases; Esopha

1989
Comparison of hypertonic glucose to other provocative tests in patients with noncardiac chest pain.
    The American journal of gastroenterology, 1987, Volume: 82, Issue:5

    Topics: Adolescent; Adult; Aged; Chest Pain; Deglutition Disorders; Diagnosis, Differential; Edrophonium; Es

1987
Esophageal testing of patients with noncardiac chest pain or dysphagia. Results of three years' experience with 1161 patients.
    Annals of internal medicine, 1987, Volume: 106, Issue:4

    Topics: Acids; Adolescent; Adult; Aged; Aged, 80 and over; Chest Pain; Deglutition Disorders; Edrophonium; E

1987
Early motor unit disease masquerading as psychogenic breathy dysphonia: a clinical case presentation.
    The Journal of speech and hearing disorders, 1971, Volume: 36, Issue:1

    Topics: Adult; Deglutition Disorders; Diagnosis, Differential; Edrophonium; Electromyography; Female; Humans

1971