edrophonium has been researched along with Congenital Myasthenia in 3 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Most congenital myasthenic syndromes (CMS) have postsynaptic defects from mutations within the muscle acetylcholine receptor (AChR)." | 1.32 | Mutation in the AChR ion channel gate underlies a fast channel congenital myasthenic syndrome. ( Beeson, D; Brydson, M; Croxen, R; Newsom-Davis, J; Vincent, A; Webster, R, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ohkawara, B | 1 |
| Cabrera-Serrano, M | 1 |
| Nakata, T | 1 |
| Milone, M | 1 |
| Asai, N | 1 |
| Ito, K | 1 |
| Ito, M | 1 |
| Masuda, A | 1 |
| Ito, Y | 1 |
| Engel, AG | 1 |
| Ohno, K | 1 |
| Schara, U | 1 |
| Della Marina, A | 1 |
| Abicht, A | 1 |
| Webster, R | 1 |
| Brydson, M | 1 |
| Croxen, R | 1 |
| Newsom-Davis, J | 1 |
| Vincent, A | 1 |
| Beeson, D | 1 |
1 review available for edrophonium and Congenital Myasthenia
| Article | Year |
|---|---|
Congenital myasthenic syndromes: current diagnostic and therapeutic approaches.
Topics: Acetylcholinesterase; Adolescent; Biopsy; Child; Cholinesterase Inhibitors; Diagnosis, Differential; | 2012 |
2 other studies available for edrophonium and Congenital Myasthenia
| Article | Year |
|---|---|
LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner.
Topics: Adolescent; Agrin; Animals; Base Sequence; beta Catenin; Cell Line; Chlorocebus aethiops; Cholinergi | 2014 |
Mutation in the AChR ion channel gate underlies a fast channel congenital myasthenic syndrome.
Topics: Adolescent; Amino Acid Sequence; Biopsy; Cell Line; DNA Mutational Analysis; Edrophonium; Electrodia | 2004 |