edrophonium has been researched along with Anesthesia in 16 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study heart rate (HR), arterial blood pressure (BP) and autonomic nervous (AN) effects of edrophonium-atropine combinations during neuromuscular blockade (NMB) antagonism in sheep." | 9.13 | Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep. ( Clutton, RE; Glasby, MA, 2008) |
| "To study heart rate (HR), arterial blood pressure (BP) and autonomic nervous (AN) effects of edrophonium-atropine combinations during neuromuscular blockade (NMB) antagonism in sheep." | 5.13 | Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep. ( Clutton, RE; Glasby, MA, 2008) |
| "08 mg/kg), 36 surgical patients undergoing barbiturate/halothane anesthesia were given edrophonium 0." | 3.67 | [Antagonism of an intubation dose of vecuronium]. ( Baar, H; Lazarus, G; Sold, M, 1987) |
| "Edrophonium may enhance (lower dose) or reduce (higher dose) cardiovascular autonomic drive in humans, as evidenced by the significant changes it evokes in HFP of the RRI (parasympathetic drive), and in the HFP and LFP of SBP (sympathetic drive)." | 2.70 | Effects of the anticholinesterase edrophonium on spectral analysis of heart rate and blood pressure variability in humans. ( Backman, SB; Chartrand, D; Deschamps, A; Fiset, P; Novak, V; Plourde, G, 2002) |
| "Mivacurium infusion was modified at five-minute intervals in order to keep the height of the first twitch in TOF(T1) at 5% of its control value." | 2.68 | Dose-response relationships for edrophonium antagonism of mivacurium-induced neuromuscular block during N2O-enflurane-alfentanil anaesthesia. ( Drolet, P; Girard, M; Marcotte, J; Perreault, L, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (68.75) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MORRIS, LE | 1 |
| SCHILLING, EA | 1 |
| FREDERICKSON, EL | 1 |
| Clutton, RE | 1 |
| Glasby, MA | 1 |
| Meakin, G | 1 |
| Sweet, PT | 1 |
| Bevan, JC | 1 |
| Bevan, DR | 1 |
| Klein, C | 1 |
| Hopkins, J | 1 |
| Beck, E | 1 |
| Burton, B | 1 |
| McCoy, EP | 1 |
| Mirakhur, RK | 2 |
| Davis, L | 1 |
| Jayarajah, MJ | 1 |
| Toner, CC | 1 |
| Flynn, PJ | 1 |
| Marcotte, J | 1 |
| Drolet, P | 1 |
| Perreault, L | 1 |
| Girard, M | 1 |
| Deschamps, A | 1 |
| Backman, SB | 1 |
| Novak, V | 1 |
| Plourde, G | 1 |
| Fiset, P | 1 |
| Chartrand, D | 1 |
| Calvey, TN | 1 |
| Williams, NE | 1 |
| Muir, KT | 1 |
| Barber, HE | 1 |
| Rupp, SM | 1 |
| McChristian, JW | 1 |
| Miller, RD | 1 |
| Taboada, JA | 1 |
| Cronnelly, R | 1 |
| Sold, M | 1 |
| Lazarus, G | 1 |
| Baar, H | 1 |
| Jones, RM | 1 |
| Cashman, JN | 1 |
| Casson, WR | 1 |
| Broadbent, MP | 1 |
| Manani, G | 1 |
| Gritti, G | 1 |
| Vecchini, L | 1 |
| Manzin, E | 1 |
| Merli, GA | 1 |
| Lumb, WV | 1 |
| Marshall, IG | 1 |
| Paul, D | 1 |
| Singh, H | 1 |
1 review available for edrophonium and Anesthesia
| Article | Year |
|---|---|
Muscle relaxants in small animal anesthesia.
Topics: Anesthesia; Animals; Cats; Cholinesterases; Decamethonium Compounds; Dogs; Edrophonium; Gallamine Tr | 1972 |
5 trials available for edrophonium and Anesthesia
| Article | Year |
|---|---|
Cardiovascular and autonomic nervous effects of edrophonium and atropine combinations during neuromuscular blockade antagonism in sheep.
Topics: Anesthesia; Animals; Atracurium; Atropine; Blood Pressure; Cholinesterase Inhibitors; Drug Therapy, | 2008 |
Comparison of the effects of neostigmine and edrophonium on the duration of action of suxamethonium.
Topics: Adult; Anesthesia; Atracurium; Cholinesterase Inhibitors; Cholinesterases; Edrophonium; Female; Huma | 1995 |
Evaluation of neuromuscular effects and antagonism of rocuronium bromide: a preliminary report.
Topics: Adolescent; Adult; Androstanols; Anesthesia; Cholinesterase Inhibitors; Double-Blind Method; Edropho | 1995 |
Dose-response relationships for edrophonium antagonism of mivacurium-induced neuromuscular block during N2O-enflurane-alfentanil anaesthesia.
Topics: Adolescent; Adult; Aged; Alfentanil; Anesthesia; Cholinesterase Inhibitors; Dose-Response Relationsh | 1995 |
Effects of the anticholinesterase edrophonium on spectral analysis of heart rate and blood pressure variability in humans.
Topics: Adult; Anesthesia; Blood Pressure; Cholinesterase Inhibitors; Edrophonium; Electrocardiography; Fema | 2002 |
10 other studies available for edrophonium and Anesthesia
| Article | Year |
|---|---|
The use of tensilon with curare and nitrous oxide anesthesia.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesiology; Curare; Edrophonium; Nitrous Oxide | 1953 |
Neostigmine and edrophonium as antagonists of pancuronium in infants and children.
Topics: Anesthesia; Child; Child, Preschool; Edrophonium; Humans; Infant; Infant, Newborn; Muscle Contractio | 1983 |
Mechanical responses to peroneal nerve stimulation in halothane-anesthetized horses in the absence of neuromuscular blockade and during partial nondepolarizing blockade.
Topics: Anesthesia; Animals; Cats; Edrophonium; Electric Stimulation; Gallamine Triethiodide; Halothane; Hor | 1983 |
Plasma concentration of edrophonium in man.
Topics: Acetylcholinesterase; Adult; Anesthesia; Animals; Edrophonium; Erythrocytes; Female; Half-Life; Huma | 1976 |
Neostigmine and edrophonium antagonism of varying intensity neuromuscular blockade induced by atracurium, pancuronium, or vecuronium.
Topics: Anesthesia; Atracurium; Edrophonium; Enflurane; Halothane; Humans; Isoquinolines; Kinetics; Neostigm | 1986 |
[Antagonism of an intubation dose of vecuronium].
Topics: Anesthesia; Edrophonium; Halothane; Humans; Intubation; Muscle Contraction; Muscle Relaxation; Neost | 1987 |
Edrophonium and plasma cholinesterase activity.
Topics: Anesthesia; Atracurium; Cholinesterases; Edrophonium; Humans; Middle Aged | 1986 |
Verapamil potentiation of neuromuscular blockade: failure of reversal with neostigmine but prompt reversal with edrophonium.
Topics: Anesthesia; Cardiomyopathy, Hypertrophic; Cholecystectomy; Drug Synergism; Edrophonium; Humans; Male | 1985 |
[Electromyographic studies of the supposed interference of Trasylol in neuromuscular block induced with curariform drugs].
Topics: Anesthesia; Animals; Aprotinin; Decamethonium Compounds; Dogs; Drug Antagonism; Edrophonium; Electro | 1968 |
The neuromuscular and other blocking actions of 4,17a-dimethyl-4,17a-diaza-d-homo-5 -androstane dimethiodide (HS-342) in the anaesthetized cat.
Topics: Androstanes; Anesthesia; Animals; Aza Compounds; Cats; Dose-Response Relationship, Drug; Edrophonium | 1973 |