edrophonium has been researched along with Amyotrophic Lateral Sclerosis in 5 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In addition, muscles with frequent fasciculations showed a larger decrement than the ones with rare fasciculation." | 1.26 | Amyotrophic lateral sclerosis. Impairment of neuromuscular transmission. ( Denys, EH; Norris, FH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Killian, JM | 1 |
| Wilfong, AA | 1 |
| Burnett, L | 1 |
| Appel, SH | 1 |
| Boland, D | 1 |
| Denys, EH | 1 |
| Norris, FH | 1 |
| Pascuzzi, RM | 1 |
| Stålberg, E | 1 |
| Thiele, B | 1 |
| Ideta, T | 1 |
| Okamoto, S | 1 |
| Okajima, T | 1 |
| Tokuomi, H | 1 |
5 other studies available for edrophonium and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Decremental motor responses to repetitive nerve stimulation in ALS.
Topics: Action Potentials; Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Edrophonium; Elect | 1994 |
Amyotrophic lateral sclerosis. Impairment of neuromuscular transmission.
Topics: Adolescent; Adult; Aged; Amyotrophic Lateral Sclerosis; Cold Temperature; Edrophonium; Fasciculation | 1979 |
Amyotrophic lateral sclerosis.
Topics: Adult; Aged; Amitriptyline; Amyotrophic Lateral Sclerosis; Cholinesterase Inhibitors; Diagnosis, Dif | 1988 |
Transmission block in terminal nerve twigs: a single fibre electromyographic finding in man.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Edrophonium; Electromyography; Humans; Motor Neuro | 1972 |
[Case of myasthenic syndrome with amyotrophic lateral sclerosis].
Topics: Amyotrophic Lateral Sclerosis; Edrophonium; Electromyography; Female; Humans; Middle Aged; Myastheni | 1973 |