edrophonium has been researched along with Aging in 7 studies
Edrophonium: A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
edrophonium : A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neostigmine has a similar, although longer, effect." | 2.69 | Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium. ( Brown, R; Fisher, DM; Fogarty, D; Kirkegaard-Nielsen, H; Sharma, ML; Szenohradszky, J, 2000) |
| "The dose-response relationship for edrophonium during antagonism of vecuronium-induced neuromuscular blockade was studied in two groups of adult patients of mean (SD) age 35 (10." | 2.68 | Dose-responses for edrophonium during antagonism of vecuronium block in young and older adult patients. ( Maddineni, VR; McCarthy, GJ; McCoy, EP; Mirakhur, RK, 1995) |
| "min-1) and a prolonged elimination half-life (84." | 2.67 | Pharmacokinetics and pharmacodynamics of edrophonium in elderly surgical patients. ( Diaz, J; Matteo, RS; Ornstein, E; Schwartz, AE; Silverberg, PA; Young, WL, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kelly, SS | 1 |
| Robbins, N | 1 |
| McCarthy, GJ | 1 |
| Mirakhur, RK | 1 |
| Maddineni, VR | 1 |
| McCoy, EP | 1 |
| Kitajima, T | 1 |
| Ishii, K | 1 |
| Ogata, H | 1 |
| Szenohradszky, J | 1 |
| Fogarty, D | 1 |
| Kirkegaard-Nielsen, H | 1 |
| Brown, R | 1 |
| Sharma, ML | 1 |
| Fisher, DM | 1 |
| Okamoto, M | 1 |
| Walewski, JL | 1 |
| Artusio, JF | 1 |
| Riker, WF | 1 |
| Matteo, RS | 1 |
| Young, WL | 1 |
| Ornstein, E | 1 |
| Schwartz, AE | 1 |
| Silverberg, PA | 1 |
| Diaz, J | 1 |
| Hollis, JB | 1 |
| Castell, DO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Can we Antagonize Mivacurium With Neostigmine[NCT03019835] | 80 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for edrophonium and Aging
| Article | Year |
|---|---|
Dose-responses for edrophonium during antagonism of vecuronium block in young and older adult patients.
Topics: Adolescent; Adult; Aged; Aging; Dose-Response Relationship, Drug; Edrophonium; Humans; Kinetics; Mid | 1995 |
Edrophonium as an antagonist of vecuronium-induced neuromuscular block in the elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressu | 1995 |
Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium.
Topics: Adult; Aged; Aging; Cholinesterase Inhibitors; Drug Interactions; Edrophonium; Female; Humans; Isoqu | 2000 |
Pharmacokinetics and pharmacodynamics of edrophonium in elderly surgical patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Clinical Trials as Topic; Edrophonium; Humans; Middle | 1990 |
3 other studies available for edrophonium and Aging
| Article | Year |
|---|---|
Bimodal miniature and evoked end-plate potentials in adult mouse neuromuscular junctions.
Topics: Aging; Animals; Calcium; Edrophonium; Electric Stimulation; Evoked Potentials; In Vitro Techniques; | 1984 |
Neuromuscular pharmacology in rat neonates: development of responsiveness to prototypic blocking and reversal drugs.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Cholinesterase Inhibitors; Curare; Dose-Response | 1992 |
Esophageal function in elderly man. A new look at "presbyesophagus".
Topics: Aged; Aging; Deglutition; Edrophonium; Esophageal Diseases; Esophagus; Gastrointestinal Motility; Hu | 1974 |