edelfosine has been researched along with Pancreatic Neoplasms in 2 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Edelfosine was taken up in significant amounts by pancreatic cancer cells and induced caspase- and mitochondrial-mediated apoptosis." | 1.38 | Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum. ( Alvarez, J; Dakir, el-H; Fonteriz, RI; Gajate, C; Matos-da-Silva, M; Mollinedo, F, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bello, C | 1 |
| Bai, J | 1 |
| Zambron, BK | 1 |
| Elías-Rodríguez, P | 1 |
| Gajate, C | 2 |
| Robina, I | 1 |
| Caffa, I | 1 |
| Cea, M | 1 |
| Montecucco, F | 1 |
| Nencioni, A | 1 |
| Nahimana, A | 1 |
| Aubry, D | 1 |
| Breton, C | 1 |
| Duchosal, MA | 1 |
| Mollinedo, F | 2 |
| Vogel, P | 1 |
| Matos-da-Silva, M | 1 |
| Dakir, el-H | 1 |
| Fonteriz, RI | 1 |
| Alvarez, J | 1 |
2 other studies available for edelfosine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells.
Topics: Antineoplastic Agents; Cell Death; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; | 2018 |
Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; DNA-Binding Proteins; Endoplasmic Retic | 2012 |