edelfosine has been researched along with Ovarian Neoplasms in 5 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ether lipid analogue 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3) has been shown to be a direct inhibitor of Swiss 3T3 fibroblast and BG1 ovarian adenocarcinoma cell cytosolic phosphoinositide selective phospholipase C (PIPLC) using [3H]-phosphatidylinositol-(4, 5)-bisphosphate ([3H]PIP2) as the substrate." | 3.68 | Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. ( Gratas, C; Melder, D; Modest, EJ; Powis, G; Riebow, J; Seewald, MJ, 1992) |
| " The dose-response curve for BG-1 cells after continuous exposure to ET-18-OMe alone was exponential with a small shoulder (Dq = 0." | 1.28 | Cytotoxic interactions of heat and an ether lipid analogue in human ovarian carcinoma cells. ( Fujiwara, K; Modest, EJ; Wallen, CA; Welander, CE, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujiwara, K | 2 |
| Daniel, LW | 1 |
| Modest, EJ | 5 |
| Wallen, CA | 2 |
| Diomede, L | 1 |
| Damia, G | 1 |
| D'Incalci, M | 1 |
| Imperatori, L | 1 |
| Algeri, M | 1 |
| Salmona, M | 1 |
| Powis, G | 1 |
| Seewald, MJ | 1 |
| Gratas, C | 1 |
| Melder, D | 1 |
| Riebow, J | 1 |
| Welander, CE | 1 |
| Noseda, A | 1 |
| Berens, ME | 1 |
| White, JG | 1 |
5 other studies available for edelfosine and Ovarian Neoplasms
| Article | Year |
|---|---|
Relationship of cell survival, drug dose, and drug uptake after 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine treatment.
Topics: Antineoplastic Agents; Cell Cycle; Cell Survival; Female; Humans; Ovarian Neoplasms; Phospholipid Et | 1994 |
In vivo anti-tumor activity of synthetic ether lipids is not enhanced by pharmacological modulation of tumor lipid composition.
Topics: Animals; Antineoplastic Agents; Cell Membrane; Cholesterol; Drug Combinations; Female; Glycerides; L | 1994 |
Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.
Topics: 3T3 Cells; Adenocarcinoma; Animals; Cell Division; Choline; Female; Mice; Ovarian Neoplasms; Phospha | 1992 |
Cytotoxic interactions of heat and an ether lipid analogue in human ovarian carcinoma cells.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Female; Hot Tempe | 1989 |
In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division | 1988 |