edelfosine has been researched along with Osteosarcoma in 4 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Their anticancer activity was tested in pediatric cancer cell lines and pharmacokinetic studies were performed in mice." | 1.56 | Squalenoyl-gemcitabine/edelfosine nanoassemblies: Anticancer activity in pediatric cancer cells and pharmacokinetic profile in mice. ( Blanco-Prieto, MJ; Couvreur, P; Mura, S; Rodríguez-Nogales, C, 2020) |
| "Paediatric solid tumours exhibit steep dose-response curves to alkylating agents and are therefore considered candidates for high-dose chemotherapy and autologous stem cell support." | 1.32 | Preferential inactivation of paediatric solid tumour cells by sequential exposure to Merocyanine 540-mediated photodynamic therapy and Edelfosine: implications for the ex vivo purging of autologous haematopoietic stem cell grafts. ( Anderson, GS; Miyagi, K; Sampson, R; Sieber, F; Tsujino, I, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodríguez-Nogales, C | 1 |
| Mura, S | 1 |
| Couvreur, P | 1 |
| Blanco-Prieto, MJ | 3 |
| González-Fernández, Y | 2 |
| Brown, HK | 1 |
| Patiño-García, A | 2 |
| Heymann, D | 1 |
| Imbuluzqueta, E | 1 |
| Zalacain, M | 1 |
| Mollinedo, F | 1 |
| Anderson, GS | 1 |
| Tsujino, I | 1 |
| Miyagi, K | 1 |
| Sampson, R | 1 |
| Sieber, F | 1 |
4 other studies available for edelfosine and Osteosarcoma
| Article | Year |
|---|---|
Squalenoyl-gemcitabine/edelfosine nanoassemblies: Anticancer activity in pediatric cancer cells and pharmacokinetic profile in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Line, Tumor; Cell Surv | 2020 |
Oral administration of edelfosine encapsulated lipid nanoparticles causes regression of lung metastases in pre-clinical models of osteosarcoma.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell | 2018 |
Doxorubicin and edelfosine lipid nanoparticles are effective acting synergistically against drug-resistant osteosarcoma cancer cells.
Topics: Doxorubicin; Drug Synergism; Humans; Nanoparticles; Osteosarcoma; Phospholipid Ethers | 2017 |
Preferential inactivation of paediatric solid tumour cells by sequential exposure to Merocyanine 540-mediated photodynamic therapy and Edelfosine: implications for the ex vivo purging of autologous haematopoietic stem cell grafts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Dose-Response Relationship, | 2003 |