edelfosine has been researched along with Neuroblastoma in 4 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Their anticancer activity was tested in pediatric cancer cell lines and pharmacokinetic studies were performed in mice." | 1.56 | Squalenoyl-gemcitabine/edelfosine nanoassemblies: Anticancer activity in pediatric cancer cells and pharmacokinetic profile in mice. ( Blanco-Prieto, MJ; Couvreur, P; Mura, S; Rodríguez-Nogales, C, 2020) |
| "Paediatric solid tumours exhibit steep dose-response curves to alkylating agents and are therefore considered candidates for high-dose chemotherapy and autologous stem cell support." | 1.32 | Preferential inactivation of paediatric solid tumour cells by sequential exposure to Merocyanine 540-mediated photodynamic therapy and Edelfosine: implications for the ex vivo purging of autologous haematopoietic stem cell grafts. ( Anderson, GS; Miyagi, K; Sampson, R; Sieber, F; Tsujino, I, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodríguez-Nogales, C | 1 |
| Mura, S | 1 |
| Couvreur, P | 1 |
| Blanco-Prieto, MJ | 1 |
| Anderson, GS | 1 |
| Tsujino, I | 1 |
| Miyagi, K | 1 |
| Sampson, R | 1 |
| Sieber, F | 1 |
| Brinkmeier, H | 1 |
| Schneider, M | 1 |
| Rüdel, R | 1 |
| Boucrot, P | 1 |
| Aubry, J | 1 |
| Mezazigh, A | 1 |
4 other studies available for edelfosine and Neuroblastoma
| Article | Year |
|---|---|
Squalenoyl-gemcitabine/edelfosine nanoassemblies: Anticancer activity in pediatric cancer cells and pharmacokinetic profile in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Line, Tumor; Cell Surv | 2020 |
Preferential inactivation of paediatric solid tumour cells by sequential exposure to Merocyanine 540-mediated photodynamic therapy and Edelfosine: implications for the ex vivo purging of autologous haematopoietic stem cell grafts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Dose-Response Relationship, | 2003 |
Ether lipid-induced cell damage of neuroblastoma cells is only weakly correlated with increased intracellular Ca2+ levels.
Topics: Animals; Antineoplastic Agents; Calcium; Cell Death; Glioma; Hybrid Cells; Mice; Neuroblastoma; Phos | 1996 |
Severe modifications of ether- ester- or diester-linked glycerolipid and non glycerolipid synthesis in human neuroblastoma LAN-1 cells cultured with octadecylmethylglycerophosphocholine.
Topics: Antineoplastic Agents; Arachidonic Acid; Carbohydrate Metabolism; Ceramides; Esters; Ethers; Ganglio | 1995 |