edelfosine has been researched along with Neural Tube Defects in 1 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Choline is an essential nutrient in methylation, acetylcholine and phospholipid biosynthesis, and in cell signaling." | 1.31 | Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. ( Fisher, MC; Mar, MH; Sadler, TW; Zeisel, SH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisher, MC | 1 |
| Zeisel, SH | 1 |
| Mar, MH | 1 |
| Sadler, TW | 1 |
1 other study available for edelfosine and Neural Tube Defects
| Article | Year |
|---|---|
Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Dyskinesia Agents; Choline; Deanol; Embryo, Mammalian; Em | 2001 |