edelfosine has been researched along with Multiple Sclerosis in 3 studies
edelfosine: RN given refers to parent cpd
edelfosine : A racemate comprising equimolar amounts of (R)- and (S)-edelfosine.
1-octadecyl-2-methylglycero-3-phosphocholine : A glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Edelfosine has been proposed for the treatment of autoimmune diseases like multiple sclerosis (MS)." | 1.40 | The orally available, synthetic ether lipid edelfosine inhibits T cell proliferation and induces a type I interferon response. ( Abramowski, P; Martin, R; Otto, B, 2014) |
| "High corticosterone levels were detected during stages of acute paralysis, whereas a decrease to normal levels was noted during each recovery phase." | 1.29 | Immunoregulation and drug treatment in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat. ( Borel, JF; Chabannes, D; Kovarik, J, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abramowski, P | 2 |
| Otto, B | 1 |
| Martin, R | 2 |
| Steinbach, K | 1 |
| Zander, AR | 1 |
| Kovarik, J | 1 |
| Chabannes, D | 1 |
| Borel, JF | 1 |
3 other studies available for edelfosine and Multiple Sclerosis
| Article | Year |
|---|---|
The orally available, synthetic ether lipid edelfosine inhibits T cell proliferation and induces a type I interferon response.
Topics: Antineoplastic Agents; Biomarkers; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; | 2014 |
Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, | 2014 |
Immunoregulation and drug treatment in chronic relapsing experimental allergic encephalomyelitis in the Lewis rat.
Topics: Animals; Autoimmune Diseases; Concanavalin A; Corticosterone; Cyclosporine; Dexamethasone; Disease M | 1995 |